Pediatric liver transplantation: 10 years of experience at a single center in Brazil

Mesquita, Marta Celeste de Oliveira; Ferreira, Alexandre Rodrígues; Veloso, Luiz Fernando; Roquete, Mariza Leitão Valadares; Lima, Agnaldo Soares; Pimenta, Júlio Rocha; Carvalho, Alexandre R.; Fagundes, Eleonora Druve Tavares; Penna, Francisco José

doi:10.2223/jped.1810

Cited by 14 publications

(8 citation statements)

References 27 publications

(13 reference statements)

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“…Em estudo recente no Hospital de Clínicas de Porto Alegre, das 33 crianças e adolescentes com insuficiência hepática aguda, a hepatite pelo vírus A foi responsável por 39% (13/33) dos casos e por 69% (9/13) dos óbitos 21 . Em Minas Gerais, Mesquita et al 22 mostraram que dos 10 casos de pacientes com hepatite fulminante transplantados apenas 5 tiveram a causa determinada, sendo que em dois deles foi relacionada ao vírus A 22 .…”

Section: Discussionunclassified

Shifting susceptibility to hepatitis A among children and adolescents over the past decade

Krebs¹,

Ranieri²,

Kieling³

et al. 2011

J Pediatr (Rio J)

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Section: Discussionunclassified

Shifting susceptibility to hepatitis A among children and adolescents over the past decade

Krebs¹,

Ranieri²,

Kieling³

et al. 2011

J Pediatr (Rio J)

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“…In the study by Mesquita and associates in 2010, in Brazil, the death rate before liver transplant was approximately 50% and was due mainly to sepsis (38.1%). 10 In this study, patients with chronic liver disease complications (eg, hepatic encephalopathy and spontaneous bacterial peritonitis), had statistically significantly higher death rates (P = .001 and P = .01). Moreover, the mortality rate of patients with hepatic encephalopathy before the transplant was 15.5-fold greater than it was for those without encephalopathy (95% CI: 3.9-61.2; OR 15.5).…”

Section: Discussionmentioning

confidence: 56%

“…According to the results, most children on a liver transplant wait list at our center were in the range of 1 to 5 years old (mean age, 6.5 years), which agrees with Mesquita and associates' study in 2008 of 84 patients (mean age, 6.6 y before liver transplant). 10 However, in the study performed by Haberal and associates in 2008 in Turkey, most participants were younger than 1 year. 11 In the current study, the most-prevalent indication for liver transplant was cryptogenic cirrhosis (28%), followed by metabolic liver diseases (18%), with tyrosinemia being the most prevalent among metabolic live diseases and biliary atresia was the third most prevalent (17%).…”

Section: Discussionmentioning

confidence: 93%

Untitled

2014

Exp Clin Transplant

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Objectives: Many children with chronic liver disease require a liver transplant. These patients are prone to various infections, including Epstein-Barr virus infection. This study sought to measure the EpsteinBarr viral load by polymerase chain reaction before a liver transplant. Materials and Methods: This cross-sectional study was done at the Shiraz University of Medical Sciences, Shiraz, Iran, in 2011. All patients were aged younger than 18 years with chronic liver disease and were candidates for a liver transplant at the Shiraz Nemazee Hospital Organ Transplant Center. They had been investigated regarding their demographic characteristics, underlying disease, laboratory findings, and Epstein-Barr viral load by real-time TaqMan polymerase chain reaction. Results: Ninety-eight patients were studied and the mean age was 6.5 ± 5.9 years. Cryptogenic cirrhosis was the most-prevalent reason for liver transplant, and the death rate before a transplant was 15%. Among the study subjects, 6 had measurable Epstein-Barr viral load by polymerase chain reaction before the transplant, and 4 of them had considerably higher Epstein-Barr viral loads (more than 1000 copies/mL). Conclusions:With respect to the close prevalence of posttransplant lymphoproliferative disease (6%) and the high Epstein-Barr viral load in the patients before a transplant (4%), high pretransplant Epstein-Barr viral load can be considered a risk factor for posttransplant lymphoproliferative disorder.

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“…The patient survival rate at six months and five yr was of 70% and 67.2%, respectively. There was no living donor in that series .…”

Section: Resultsmentioning

confidence: 95%

Pediatric liver transplantation in Latin America: Where do we stand?

Feier

Antunes

D’Agostino

et al. 2016

Pediatric Transplantation

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LT started in LA in 1968, and pediatric LT records are available starting in the 1990s. Currently, eight countries perform pediatric LT in LA. Registries by national organizations fail to report robust data on pediatric LT. The aim of this paper was to report on the pediatric LT activity in LA. Data were gathered retrospectively through information available in the national registries websites and from local centers. Of the eight countries that report pediatric LT activity, Brazil, Argentina, Mexico, and Colombia have adequate registries of the numbers of LT performed. These countries concentrate most of the activity for pediatric LT. A total of 4593 pediatric LT were reported in LA. Websites for national organizations do not provide open data on post-transplant survival rates or waiting list mortality. The information herein is based on reports by local centers. Overall, survival from select centers is similar to that reported on North American and European registries, between 80 and 90% in the first year post-transplant. In conclusion, pediatric LT activity is growing in LA, especially in Brazil and Argentina. However, the lack of an appropriate LA registry restricts the assessment of quality and therefore restricts interventions aimed at quality improvements in different regions.

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Pediatric liver transplantation: 10 years of experience at a single center in Brazil

Cited by 14 publications

References 27 publications

Shifting susceptibility to hepatitis A among children and adolescents over the past decade

Shifting susceptibility to hepatitis A among children and adolescents over the past decade

Untitled

Pediatric liver transplantation in Latin America: Where do we stand?

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