Neurobehavioral Effects of β-Escin

Waheed, Huda Jaber; Nashtar, Saad B.; Al-Gareeb, Ali I; Al-Kuraishy, Hayder M

doi:10.2174/2211556007666180523103828

Cited by 3 publications

(3 citation statements)

References 23 publications

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“…Aesculus hippocastanum L., belonging to the Hippocastanaceae family and commonly referred to as horse chestnut, is a native of Western Asia. In addition to treating leg ulcers and varicose veins, hemorrhoids, cellulitis, hematomas, edema, venous insufficiency, pain, and swelling, it may also reduce swelling and pain [ 14 ]. Escin, a combination of triterpene saponins, is the primary active component of A. hippocastanum .…”

Section: Introductionmentioning

confidence: 99%

Biopolymer Chitosan Surface Engineering with Magnesium Oxide-Pluronic-F127-Escin Nanoparticles on Human Breast Carcinoma Cell Line and Microbial Strains

et al. 2023

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Nanotechnology has been recognized as a highly interdisciplinary field of the twenty-first century, with diverse applications in biotechnology, healthcare, and material science. One of the most commonly employed non-toxic nanoparticles, magnesium oxide nanoparticles (MgO NPs), is simple, inexpensive, biocompatible, and biodegradable. Several researchers are interested in the biosynthesis process of MgO NPs through chemical and physical approaches. This is because of their simplicity, affordability, and environmental safety. In the current study, green MgO-Chitosan-Pluronic F127-Escin (MCsPFE) NPs have been synthesized and characterized via various techniques like UV-visible, Fourier-transform infrared spectroscopy, Energy dispersive X-ray composition analysis, Transmission electron microscopy, field emission scanning electron microscopy, X-ray Diffraction, Photoluminescence, and Dynamic light scattering analyses. The average crystallite size of MCsPFE NPs was 46 nm, and a face-centered cubic crystalline structure was observed. Further, the antimicrobial effectiveness of NPs against diverse pathogens has been assessed. The cytotoxic potential of the nanoparticles against MDA-MB-231 cell lines was evaluated using the MTT test, dual AO/EB, JC-1, DCFH–DA, and DAPI staining procedures. High antimicrobial efficacy of MCsPFE NPs against Gram-positive and Gram-negative bacterial strains as well as Candida albicans was observed. The findings concluded that the NPs augmented the ROS levels in the cells and altered the Δψm, leading to the initiation of the intrinsic apoptotic cell death pathway. Thus, green MCsPFE NPs possess immense potential to be employed as an effective antimicrobial and anticancer treatment option.

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Section: Introductionmentioning

confidence: 99%

Biopolymer Chitosan Surface Engineering with Magnesium Oxide-Pluronic-F127-Escin Nanoparticles on Human Breast Carcinoma Cell Line and Microbial Strains

et al. 2023

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“…Motor symptoms of konzo are permanent and irreversible. Deficits in fine motor control, in association with exaggerated deep tendon reflexes or ankle clonus, are commonly found in the general population of konzo-affected areas, suggesting the existence of subclinical and preclinical konzo [4,5,6,7,8,9] ( Waheed et al, 2020). The World Health Organization [10], graded the severity of konzo according to the following: mild konzo (able to walk with no support), moderate konzo (needs support to walk), and severe konzo (Unable to walk).…”

Section: Introductionmentioning

confidence: 99%

Neurobehavioural Changes and not Structural Changes Occur in Rat Fed with Cassava Products (Fufu, Garri and Tapioca Diet)

David

Umeakaelu

Ibeachu

2021

ACRI

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The ability of cassava products (fufu, garri and tapioca) to produce behavioral and structural changes in the brain of adult rats was examined. Forty adult male rats (N=40) were used for this study and the experiment was divided into two phases (N=20 each).Rat were trained in a Reach-To-Grasp Task for 6 weeks and Quantitative assessments using a reaching movement scale and reach-to-grasp success rate were carried out to determine baseline values. After which administration of the various cassava products was done. The 1st phase had the rats trained to perform the reach to grasp experiment before been fed with various cassava diet. In this phase the animals performed significantly worse than the controls when determining the average success rate in a reach-to-grasp experiment (baseline=72.6%, fufu diet= 30%, garri diet =47%, tapioca diet =59%). The 2nd phase had the rats trained simultaneously as they were being fed withvarious cassava diet. In this phase the animals also performed significantly worse than the controls when determining the average success rate in a reach-to-grasp experiment (fufu diet= 37.5%, garri diet =46.5%, tapioca diet =56.5%). The various movement of the rat was assessed using Tracker software (Video Analysis and Modeling tool, version 5.1.2) and the movement pattens were determined. The animals fed with Fufu shows the worst movement pattern indicating aiming impairment which may be as a result of structural changes in the m1 region of the cerebral cortex. The data obtained were analysed using ANOVA and there was significant difference (p < 0.05) in the movement pattern. Histological observation showed no neuropathological changes in the motor cortex. The rats fed with cassava diets shows no observable changes in the structures and sizes of the neurons as compared with the control. Cassava products (Fufu, Garri and Tapioca) have been demonstrated to cause neurobehavioural and mild structural changes in the M1 region of the cerebral cortex.

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“…[ 4 ] Aesculus hippocastanum L. from Hippocastanaceae family, known as horse chestnut, is commonly native to Western Asia used in the treatment of different medical conditions including leg ulcer, varicose veins, hemorrhoids, cellulitis, hematoma, and edema. [ 5 ]…”

Section: Introductionmentioning

confidence: 99%

Aesculus hippocastanum-Derived extract β-Aescin and in vitro antibacterial activity

Dahash

Abass

Abdul-Razaq

et al. 2021

J Microsc Ultrastruct

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Objectives: The objective of this study was to investigate the antibacterial activity of β-aescin against common Gram-negative and Gram-positive bacteria. Materials and Methods: Agar well diffusion assay was used to determine the antibacterial activity of β-aescin against common Gram-negative and Gram-positive bacteria including Klebsiella pneumoniae, Escherichia coli, Staphylococcus epidermidis, Staphylococcus aureus, and Pseudomonas aeruginosa . Minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of β-aescin were evaluated by serial dilution method. Results: β-aescin led to significant antibacterial effects on the tested Gram-negative and Gram-positive bacteria compared to the negative control, P < 0.05 for K. pneumoniae and P. aeruginosa and P < 0.01 for E. coli, S. epidermidis, and S. aureus . On the other hand, β-aescin produced a comparable less antibacterial effect on K. pneumoniae, E. coli, and P. aeruginosa compared to the positive control, P < 0.01, whereas β-aescin illustrated a comparable effect with that of the positive control on Gram-positive S. epidermidis, P = 0.05. Furthermore, β-aescin illustrated a concentration-dependent antibacterial effect against Gram-positive S. epidermidis and S. aureus compared to the different concentrations, P < 0.01. MIC and MBC of β-aescin were high for Gram-negative bacteria and low for Gram-positive bacteria compared to MIC of the positive control. Conclusions: β-aescin is an effective antibacterial herb mainly against Gram-positive S. epidermidis and S. aureus in a concentration-dependent manner.

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Neurobehavioral Effects of β-Escin

Cited by 3 publications

References 23 publications

Biopolymer Chitosan Surface Engineering with Magnesium Oxide-Pluronic-F127-Escin Nanoparticles on Human Breast Carcinoma Cell Line and Microbial Strains

Biopolymer Chitosan Surface Engineering with Magnesium Oxide-Pluronic-F127-Escin Nanoparticles on Human Breast Carcinoma Cell Line and Microbial Strains

Neurobehavioural Changes and not Structural Changes Occur in Rat Fed with Cassava Products (Fufu, Garri and Tapioca Diet)

Aesculus hippocastanum-Derived extract β-Aescin and in vitro antibacterial activity

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