Chitosan-Sodium Alginate Polyelectrolyte Complex Coating Pluronic® F127 Nanoparticles Loaded with Citronella Essential Oil

Sanches, Mariele Paludetto; Gross, Idejan P.; Saatkamp, Rodrigo H.; Parize, Alexandre Luís; Soldi, Valdir

doi:10.21577/0103-5053.20190244

Cited by 5 publications

(8 citation statements)

References 29 publications

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“…To modify the polarity of the solvent (distilled water), we include alcohol in the formulation as the release media. According to Sanchez et al [42] (2020) the ethanol is added to help release the essential oil more uniformly.…”

Section: Cabreuva Essential Oil Releasementioning

confidence: 99%

Electrospun nanofibers of poly(vinyl alcohol) and chitosan-based emulsions functionalized with cabreuva essential oil

Lamarra

Calienni

Rivero

et al. 2020

International Journal of Biological Macromolecules

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Cabreuva Essential Oil Releasementioning

confidence: 99%

Electrospun nanofibers of poly(vinyl alcohol) and chitosan-based emulsions functionalized with cabreuva essential oil

Lamarra

Calienni

Rivero

et al. 2020

International Journal of Biological Macromolecules

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“…[25,32] The band related to stretching vibrations of OH and NH bonds in Ca-alginate-chitosan and Ca-alginate-chitosan-pequi oil microspheres were both dislocated for lower wavenumber in comparison to pure biopolymers (Figure 3), indicating intermolecular hydrogen bonds. [22] For the microspheres formed only by Ca-alginate-chitosan, a shift of the asymmetric stretching C═O group was observed in the alginate spectrum at 1614 cm −1 to 1641 cm −1 , and the symmetric stretching C═O group also shifted from 1419 to 1454 cm −1 . The absorption of amino chitosan groups was displaced to 1544 cm −1 (Figure 3).…”

Section: Fourier Transform Infrared Spectroscopy (Ftir)mentioning

confidence: 91%

“…In the present work, chitosan was added to the gelling bath to reinforce the particle-matrix as indicated in studies by Sanches et al (2020) and YADAV et al (2018). [22,23] In this work, particles were prepared by ionotropic gelation of an alginate core followed by chitosan polyelectrolyte complexation. In fact, calcium ions react with guluronic acid units of alginate to form an "egg-box" structure.…”

Section: Particle Formation Of Pequi Oilmentioning

confidence: 99%

“…The absorption of amino chitosan groups was displaced to 1544 cm −1 (Figure 3). [22,35] When compared to pure biopolymers (Figure 3), changes in the absorption indicate electrostatic interaction in the Ca-alginate-chitosan complex. [23,25,32] The interaction between the biopolymers will enable the microspheres to present greater resistance and a controlled release in more specific media such as the stomach and intestine.…”

Section: Fourier Transform Infrared Spectroscopy (Ftir)mentioning

confidence: 99%

“…[23,25,32] The interaction between the biopolymers will enable the microspheres to present greater resistance and a controlled release in more specific media such as the stomach and intestine. [22,23,25,36] The microsphere spectrum formed by Ca-alginate-chitosanpequi oil has characteristic bands for pequi oil and alginate; asymmetrical and symmetrical C─H stretching intense in CH 2 (2920 and 2853 cm −1 , respectively) and C═O stretching (1746 cm −1 ), both characteristic of pequi oil; and symmetrical C═O stretching (1419 cm −1 ) in alginate. The band at 1593 cm −1 indicates the effect of electrostatic interaction between the C═O group of alginate and Ca +2 /chitosan in the presence of pequi oil (Figure 3).…”

Section: Fourier Transform Infrared Spectroscopy (Ftir)mentioning

confidence: 99%

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Development and Characterization of Pequi Oil (Caryocar coriaceum wittm.) Microparticles by Vibration Nozzle Encapsulation

Castelo

Silva

Sousa

et al. 2020

Macromolecular Symposia

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Pequi oil has a high content of bioactive compounds identified in its composition, which gives it excellent potential for use in the food and pharmaceutical industries. Oil microencapsulation offers favorable conditions for storage and controlled release in order to maintain its functional characteristics for a longer time. In this study, vibration nozzle microencapsulation technology is applied to the production of pequi oil microparticles using sodium alginate. After encapsulation, the electrolytic complexation of the particles with chitosan is performed. The influence of frequencies (1500, 1800, 2000, 2500 Hz) on particle size and morphology is evaluated using the 120 µm nozzle. The microparticles formed at 1800 and 2000 Hz presented smaller size and greater sphericity, respectively. The formation of the electrolytic complex from alginate and chitosan is confirmed by FTIR analysis. Frequency adjustment is important for obtaining spherical and homogeneous particles. The encapsulation efficiency of pequi oil in alginate‐chitosan matrix is 96.17%. Electrolytic complexation of the alginate particles with chitosan can improve the reinforcement of the matrix and favor future application in the industry.

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Inhalation potential of N-Acetylcysteine loaded PLGA nanoparticles for the management of tuberculosis: In vitro lung deposition and efficacy studies

Puri

Chaudhary

Singh

et al. 2022

Current Research in Pharmacology and Drug Discovery

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Several studies have stated that mucus is a critical hurdle for drug delivery to the mucosal tissues. As a result, Polymeric nanoparticles that can overcome mucus barriers are gaining popularity for controlled drug delivery into intra-macrophages to attain high intracellular drug concentration. The present study was aimed to fabricate inhalable N-acetylcysteine (NAC) modified PLGA mucus penetrating particles using the double emulsion method (w/o/w) for target delivery to alveolar macrophages and minimize the dose-related adverse effects, efficiently encapsulate hydrophilic drug, sustain the release profile and prolong the retention time for the management of tuberculosis. Among the numerous formulations, the drug/polymer ratio of 1:10 with 0.50% PVA concentration and sonication time for 2 min s was chosen for further research. The formulated nanoparticles had a mean particle size of 307.50 ± 9.54 nm, PDI was 0.136 ± 0.02, zeta potential about −11.3 ± 0.4 mV, decent entrapment efficiency (55.46 ± 2.40%), drug loading (9.05 ± 0.22%), and excellent flowability. FTIR confirmed that NAC and PLGA were compatible with each other. SEM graphs elucidated that the nanoparticles were spherically shaped with a slightly rough surface whereas TEM analysis ensured the nanometer size nanoparticles and coating of lipid over NPs surface. PXRD spectrum concluded the transformation of the drug from crystalline to amorphous state in the formulation. In vitro release pattern was biphasic started with burst release (64.67 ± 1.53% within 12hrs) followed by sustained release over 48hrs thus enabling the prolonged replenishing of NAC. In vitro lung deposition study pronounced that coated NAC-PLGA-MPPs showed favorable results in terms of emitted dose (86.67 ± 2.52%), MMAD value (2.57 ± 0.12 μm), GSD value (1.55 ± 0.11 μm), and FPF of 62.67 ± 2.08% for the deposition and targeting the lungs. Finally, in vitro efficacy studies demonstrated that NAC-PLGA-MPPs presented more prominent antibacterial activity against MTB H37Rv strain as compared to NAC. Hence, PLGA based particles could be a better strategy to deliver the NAC for lung targeting.

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Chitosan-Sodium Alginate Polyelectrolyte Complex Coating Pluronic® F127 Nanoparticles Loaded with Citronella Essential Oil

Cited by 5 publications

References 29 publications

Electrospun nanofibers of poly(vinyl alcohol) and chitosan-based emulsions functionalized with cabreuva essential oil

Electrospun nanofibers of poly(vinyl alcohol) and chitosan-based emulsions functionalized with cabreuva essential oil

Development and Characterization of Pequi Oil (Caryocar coriaceum wittm.) Microparticles by Vibration Nozzle Encapsulation

Inhalation potential of N-Acetylcysteine loaded PLGA nanoparticles for the management of tuberculosis: In vitro lung deposition and efficacy studies

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