Use of Natural Deep Eutectic Solvents for Polymerization and Polymer Reactions

Gómez, Analía Verónica; Biswas, Atanu; Tadini, Carmen C.; Furtado, Roselayne Ferro; Alves, Carlúcio Roberto; Cheng, H. N.

doi:10.21577/0103-5053.20190001

Cited by 11 publications

(11 citation statements)

References 76 publications

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“…However, DESs are usually less toxic, easier to prepare, and less expensive than ILs. These advantages have led to the recent increase in applications of DESs, for example, as solvents in diverse separation methods [4][5][6][7][8], media for chemical [9][10][11][12][13][14], electrochemical [15][16][17][18][19], and biological reactions [20,21], in polymer chemistry [22][23][24], and for increasing the solubility of active pharmaceutical ingredients [25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Design of Deep Eutectic Systems: A Simple Approach for Preselecting Eutectic Mixture Constituents

2020

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Eutectic systems offer a wide range of new (green) designer solvents for diverse applications. However, due to the large pool of possible compounds, selecting compounds that form eutectic systems is not straightforward. In this study, a simple approach for preselecting possible candidates from a pool of substances sharing the same chemical functionality was presented. First, the melting entropy of single compounds was correlated with their molecular structure to calculate their melting enthalpy. Subsequently, the eutectic temperature of the screened binary systems was qualitatively predicted, and the systems were ordered according to the depth of the eutectic temperature. The approach was demonstrated for six hydrophobic eutectic systems composed of L-menthol and monocarboxylic acids with linear and cyclic structures. It was found that the melting entropy of compounds sharing the same functionality could be well correlated with their molecular structures. As a result, when the two acids had a similar melting temperature, the melting enthalpy of a rigid acid was found to be lower than that of a flexible acid. It was demonstrated that compounds with more rigid molecular structures could form deeper eutectics. The proposed approach could decrease the experimental efforts required to design deep eutectic solvents, particularly when the melting enthalpy of pure components is not available.

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Section: Introductionmentioning

confidence: 99%

Design of Deep Eutectic Systems: A Simple Approach for Preselecting Eutectic Mixture Constituents

2020

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“…The experimental values of the melting point (T m ) for sorbitol, malic acid, and the glass transition temperature (T g ) for sorbitol-based NADES evaluated by DSC method are presented in Table 1. As can be seen from the data presented in Table 1, the sorbitol-based NADES (row 3) with sorbitol:malic acid:water (1:1:1 mole ratio) content has low glass transition temperature (−56 • C) that is much less than for sorbitol with the melting point equal to 97 • C and for malic acid with the melting point equal to 130 • C. There is confirmed information about the status of this mixture as a natural deep eutectic solvent [25,28,29]. It is should be mentioned that the weight loss for the sample after the three runs was equal to 4% and the glass transition temperature decreased approximately by 3.0 • C. That is these results provide a possibility for this type of NADES use at a room temperature for the extraction of BASs from the plant raw material.…”

Section: Resultsmentioning

confidence: 62%

“…Some articles describe two main formulations of sorbitol based NADESs: sorbitol:malic acid:water (1:1:3 in mole ratio), sorbitol:malic acid (1:1 in mole ratio) [25,28,29]. It should be noted no information has been found in the scientific literature about the studies of the extraction properties of sorbitol-based solvents and sorbitol-based NADESs relative to the main BASs from Glycyrrhizae roots.…”

Section: Introductionmentioning

confidence: 99%

Studying and Modeling of the Extraction Properties of the Natural Deep Eutectic Solvent and Sorbitol-Based Solvents in Regard to Biologically Active Substances from Glycyrrhizae Roots

et al. 2020

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The purpose of this work was the studying and modeling of the extraction properties of the sorbitol-based natural deep eutectic solvent (NADES) and sorbitol-based solvents in regard to biologically-active substances (BASs) from Glycyrrhizae roots using theoretical fundamentals based on the laws of statistical physics, thermodynamics, and physical chemistry previously developed by us. In our studies, we used Glycyrrhizae roots, simple maceration, plant raw material:solvent ratio 1:10 w/v, temperature 25 °C, extraction time 24 h; standards of licuroside and glycyram; RP HPLC, differential scanning calorimetry, integral dielectric, impedance and conductivity spectroscopy method of analysis; the following solvents: sorbitol-based NADES sorbitol:malic acid:water (1:1:3 in molar ratio), a modified solvent based on NADES sorbitol:malic acid:water:glycerin (1:1:1:1 in molar ratio) and sorbitol-based solvents sorbitol:ethanol:water at different ratios. It has been found that regression equations for sorbitol-based solvents in coordinates predicted by the theory have a high value of determination coefficient that equals to R2e = 0.993 for glycyram and R2e = 0.976 for licuroside. It has been found that the extraction properties of sorbitol-based NADES with a dielectric constant (ε) equal to 33 ± 2 units are equivalent to those of the sorbitol:ethanol:water solvent with ε = 34 units, and the extraction properties of modified solvent based on NADES with ε = 41 ± 2 units are inferior to those of the sorbitol-ethanol-water solvents with maximum value of BASs yield with the dielectric constant range 40 ÷ 50 units. The theoretical fundamentals suggested provide a possibility for an explanation of the mechanism, quantitative description of the extraction properties of the solvent, and target search of the optimal solvent by its dielectric constant.

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“…In view of the current interest in green chemistry, new or improved extraction methodologies that do not involve organic solvents are desirable. A promising recent solvent approach involves the natural deep eutectic solvents (NADES) [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

“…A NADES solvent contains two or three natural, renewable, and biodegradable natural components, which form a eutectic mixture because of self-association and/or specific interactions among the solvent components [16][17][18][19]. A distinctive feature of the eutectic mixture is the melting point, which is lower than the melting points of the individual components; the NADES of interest are liquids from room temperature to 100 ºC.…”

Section: Introductionmentioning

confidence: 99%

Effects of Microwave and Water Incorporation on Natural Deep Eutectic Solvents (NADES) and Their Extraction Properties

Gómez¹,

Biswas²,

Tadini³

et al. 2018

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One of the common processes employed in food technology and preparation is the extraction of specific components from agro-based materials. Although many methodologies are known, continued improvements are still desirable. A recent new development is the use of natural deep eutectic solvents (NADES) for extraction. In this work, we studied NADES/water combinations and found them to be viable alternatives to conventional solvents for extraction of polar ingredients in foods. The NADES/water solvents are eco-friendly, inexpensive, chemically inert, and biodegradable. Moreover, we found microwave heating to facilitate the preparation of NADES/water solvents. Selected NADES/water systems were characterized with respect to viscosity, refractive indices, electrical conductivity, water activity, and NMR. In addition, we utilized the microwave process to facilitate the extraction of sugars in a food product with a NADES/water system. The microwave process was found to be efficient, save time, and decrease energy usage. Thus, the combination of NADES/water/microwave is a versatile method that can provide improved extractions in food systems.

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Use of Natural Deep Eutectic Solvents for Polymerization and Polymer Reactions

Cited by 11 publications

References 76 publications

Design of Deep Eutectic Systems: A Simple Approach for Preselecting Eutectic Mixture Constituents

Design of Deep Eutectic Systems: A Simple Approach for Preselecting Eutectic Mixture Constituents

Studying and Modeling of the Extraction Properties of the Natural Deep Eutectic Solvent and Sorbitol-Based Solvents in Regard to Biologically Active Substances from Glycyrrhizae Roots

Effects of Microwave and Water Incorporation on Natural Deep Eutectic Solvents (NADES) and Their Extraction Properties

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