Insights into Protein-Ionic Liquid Interactions Aiming at Macromolecule Delivery Systems

Investigation of the solubility and dispersion degree of calf skin collagen in ionic liquids

“…However, the degree of dispersion degree varied in [ were much more sparsely distributed with the increase of ILs concentrations. Such differences might be attributed to the lyotropic action and reorientation of the hydration network of collagen induced by ILs with different ions and polarity [10,23]. The high polarity can reduce the water associated with collagen, lower its viscosity and consequently increase the mobility of collagen fibers and become looser.…”

“…Also, since complete dissolution of collagen in ILs was not achieved, the insoluble part of collagen had not been thoroughly studied. Furthermore, it should be noted that both the sorts and concentrations of ILs, which are closely related to their polarity, have great influences on the properties of collagen [10,19,[23][24][25][26][27][28]. For example, the differences in composition of imidazolium-based ILs endowed by varying anions with different polarity namely acetate, hydrogen sulfate, dicyanamide, dimethyl phosphate, dihydrogen phosphate and sulfate, had resulted in different destabilizing effects on the triple helical structure of collagen [25]; a notable decreasing trend in denaturation temperature of collagen fibers was discovered with the increase of ILs concentration from 0.1% to 10% (w/v) [10].…”

Unveiling the Influence of Non-Toxic Fluorinated Ionic Liquids Aqueous Solutions in the Encapsulation and Stability of Lysozyme

“…Proteins are complex bioactive entities playing a wide variety of roles in all living systems, and having high relevance in different fields such as the biopharmaceutical industry, therapeutic components, food science and biocatalysts [1][2][3][4]. Proteins' functionality is entirely dependent on the maintenance of their three-dimensional structure in solution, which is the result of weak interactions, such as hydrogen bonds and hydrophobic and ionic interactions.…”

A drug delivery system obtained by hot-melt processing of zein plasticized by a pharmaceutically active ionic liquid

“…14,15 In the present case, no significant weight loss is found Various but efficient protective interactions (e.g., hydrogen bonds, hydrophobic and electrostatic interactions), have been shown to enhance the thermal stability of ionic liquidprotein blends. 9 The second one from 250 to 500°C is ascribed to the decomposition of zein and is lightly shifted to lower temperature after incorporation of [Lid] [Ibu]. From these results, it can be concluded that a thermomechanical treatment is possible up to about 150°C.…”

“…5 Active Pharmaceutical Ingredient -Ionic Liquids (API-IL) are considered as among the most promising compounds for future drugs, especially because they can be easily dosed and processed to prepare pharmaceuticals with better solubility, absorbability and stability than solid forms. 6 The release of API-IL from edible and resorbable matrices is the next step of using these drugs 7,8 , as in the case of protein-based materials because of numerous potential interactions between such hetero-polymers and active ingredient molecules 8,9 and recently highlighted especially for zein. 10,11 [Lidocainium][Ibuprofenate], named [Lid][Ibu], has a triple interest : (i) a plasticizing effect on biopolymers (e.g.…”