2023
DOI: 10.21577/0100-4042.20230055
|View full text |Cite
|
Sign up to set email alerts
|

Electron Withdrawing Group Effect on Biological Activities of Pyrimidine Hybrids as Potential Anti-Matrix Metalloproteinase-7

Abstract: We investigated the effect of both electron donating group and e//lectron withdrawing group on biological activity of pyrimidine-based compounds as metalloproteinase-7 inhibitors and predicting a library of drug-like compounds with potent cytotoxicity using in silico approach. The selected compounds were optimized and subjected to both docking as well as absorption, distribution, metabolism, excretion and toxicity (ADMET) analyzes. We observed that the addition of electron withdrawing group (–CF3) to the predi… Show more

Help me understand this report

This publication either has no citations yet, or we are still processing them

Set email alert for when this publication receives citations?

See others like this or search for similar articles