Avaliação Do Perfil De Liberação Do Fármaco Ibuprofeno Em Membranas Simétricas E Assimétricas De Acetato De Celulose: Efeito Da Morfologia

Abstract

Recebido em 21/04/2019; aceito em 30/07/2019; publicado na web em 11/09/2019 EVALUATION OF THE IBUPROFEN DELYVERY PROFILE IN SYMMETRIC AND ASYMMETRIC MEMBRANES OF CELLULOSE ACETATE: EFFECT OF MORPHOLOGY. Cellulose derivatives still receive special attention in today biomedical applications due to their biocompatibility, ability to form resistant membranes and compatibility with various bioactive agents. In this work, cellulose acetate (CA) was used to prepare membranes with different morphologies aiming to evaluate the release profile of the drug ibuprofen (IBF). The IBF incorporation was performed by the addition of 10% of the drug in an 8% (w/w) CA/acetone solution. The morphology of the membranes was modified by the addition of water, used as porogenic agent. Drug release assays showed the effect of morphology on the cumulative drug release curves. The symmetric membrane exhibited retention of significant amounts of the drug and a slow release process that lasted for more than 50 hours. The asymmetric porous membranes presented different behavior with greater amount of drug released in less time of release. The kinetic parameters calculated from the Higuchi and Korsmeyer/Peppas models indicated release profiles controlled by diffusion/solution process in the polymer matrix. The results revealed that the interactions established between IBF, CA and the matrix morphology are significant factors for the kinetic control of the drug release process and enable to choose different applications of the membranes loaded with IBF.

Thermal Decomposition Kinetics of Ibuprofen and Naproxen Drugs Incorporated in Cellulose Acetate Matrices

“…E continued to increase up to ≈141 kJ mol −1 at 75% conversion ( = 0.75). Therefore, E values indicated an intense association of CA with both drugs, enabling an increase in thermal stability which can be attributed to the formation of hydrogen bonds between the carboxylic acid groups of the drugs and the free hydroxyls of CA, which is in agreement with the results reported by Ma et al [17] and Ferreira et al [13] Finally, the results showed both systems consist of good solid dispersions with well-distributed drugs. However, the calculated E values suggest the CA-NPX system has a stronger interaction established between the drug and the CA matrix relative to CA-IBF.…”

“…TGA www.advancedsciencenews.com www.ms-journal.de Adapted from. [ 11,13] curves for IBF and NPX exhibited the main thermal events responsible for 100% of mass loss at a temperature of around 200 to 250°C, respectively. A major thermal event responsible for the degradation of CA is observed at 332°C with a mass loss of approximately 75%, while CA-drug membranes showed a mass loss of 65%, which is related to the thermal decomposition of the membrane's CA main chains at ∼328°C.…”

“…[14] 10 wt.% of each drug was added to the fresh CA solution to prepare the membranes CA-IBF and CA-NPX. [12,13] The CA/drug solution was spread into a 9.5 cm diameter Petri dish and then the solvent was freely evaporated throughout 12 h at 27°C.…”

“…To date, there is no published work studying the intensity of these intermolecular interactions. [12,13]…”

Low‐cost conductive films based on graphite and cellulose acetate as promising electroanalytical platforms

“…Cellulose acetate (CA), in special, is a polymer widely used as a matrix for several applications including water purification and desalination, 18–20 gas separation, 21 drug release, 22 and sensor fabrications 23 . The vast applicability is essentially due to the low cost, low toxicity, and the ability to form films.…”