Perspectivas Da Química Medicinal Para O Século Xxi: Desafios E Oportunidades

Abstract

In the 21st century, medicinal chemists will face many challenges to improve the quality of life of populations. The challenges consist of emerging infectious (ex. bacterial, viral and parasite infections) and non-communicable diseases (ex. autoimmune, Alzheimer disease, Parkinson's disease) that will require innovative technologies (ex. microfluidics, nanotechnology, biotechnology) to be fully understood and combated. In this work, we indicate trends, perspectives and opportunities related to drug discovery as well as highlight the tools and strategies that could be used in drug discovery of the 21st century.

Caracterização química de extratos brutos obtidos de dois fungos endofíticos isolados de Cochlospermum regium / Chemical characterization of crude extracts obtained from two endophytic fungi isolated from Cochlospermum regium

“…Compostos aromáticos apresentam características antioxidantes (Andrade, 2018;Sousa, 2007), vários fungos endofíticos já foram relatados contendo atividade antioxidantes (Alves et al, 2020) devido a sua produção de compostos aromáticos (Arruda et al, 2021, Chapla et al, 2013. Esta propriedade pode estar associada a proteção do hospedeiro de fatores abióticos, como o composto 3 que tem propriedade de filtrar raios ultravioletas (UV-B, 280-320nm) e já foi detectado em plantas nas regiões superficiais da estrutura vegetal (Azevedo, 1998;Gobbo-Neto, 2007;Ferreira, 2008).…”

The interdisciplinarity in drug discovery

“…11 This method is applied to virtual collections of compounds in an automated way, a mass virtual test. 12 In this context, the chemoinformatics, an interdisciplinary area that uses in an integrated way computational resources, information technology and chemical information, 13 has consolidated and its usefulness and impact to the medicinal chemistry tends to increase in the coming decades. Given the high expansion of databases with chemical information and biological properties relevant, and its exploitation and transformation of informations in the generated knowledges is essential for the discovery of new compounds with desired properties.…”

“…Given the high expansion of databases with chemical information and biological properties relevant, and its exploitation and transformation of informations in the generated knowledges is essential for the discovery of new compounds with desired properties. 13 The potential ligands delineated in the computational studies go to the in vitro screening, these tests are also important to screening of collections of molecules of natural origin or of combinatorial organic synthesis products. 14 Considering the large number of virtual and real molecules, before the in vitro assays, the compounds are subjected to filters that consider the pharmacophoric groups already known, 15 pharmacokinetic parameters, as the rule of the five of Lipinski's, 4,16 and the synthetic viability, in the case of virtual molecules.…”

Ciclodextrinas: Possíveis agentes terapêuticos em doenças neurodegenerativas

“…Diante dessa perspectiva, considera que atualmente os tratamentos para essas doenças são bastante limitados, já que os existentes atuam apenas de forma paliativa. Essa escassez traz a provocação para que novos fármacos sejam desenvolvidos (Andrade, et al, 2018).…”