Modelos estereoquímicos de adição à carbonila

Martins, Bruna S.; Lüdtke, Diogo S.; Moro, Angélica V.

doi:10.21577/0100-4042.20160186

Cited by 1 publication

(1 citation statement)

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“…[15][16][17][18][19] Eclipsed conformations are most likely found in complexes with formyl compounds and boron Lewis acids. [20] This case is particularly useful for stereochemical control in carbonyl addition reactions [21] (Figure 1). Therefore, we present an indepth theoretical conformational analysis of β-substituted ethylboranes (substituent, X = H, CH 3 , F, Cl, NH 2 , PH 2 , OH, and SH) to examine the substituent effects on sp 2 -sp 3 rehybridization at the boron atom.…”

Section: Introductionmentioning

confidence: 99%

Conformational and Substituent Effects on The Rehybridization of Boron in β‐Substituted Ethylboranes

Martins

Freitas

2021

Asian J Org Chem

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The chemistry of boron-containing molecules pervades the study of biomolecules, new materials, organic synthesis, and beyond. In addition, the stereochemistry and rehybridization capability of boron in molecules influence the reactivity and selectivity of reactions. Therefore, conformational analysis and the study of substituent effects on the modulation of the sp 2 -sp 3 character of boron in β-substituted ethylboranes may be valuable for the rational design of compounds in which the empty p B orbital plays a central role in the reaction intermediate. Accordingly, we have quantumchemically studied the orbital interactions and bonding properties that govern the conformational behavior and boron hybridization in β-substituted ethylboranes (substituents, X = H, CH 3 , F, Cl, NH 2 , PH 2 , OH, and SH). Conformations with an anti arrangement along the BÀ CÀ CÀ X path are generally preferred over syn and/or gauche conformations, while a BÀ H bond tends to eclipse with the CÀ C bond rather than with a less sterically hindered CÀ H bond. However, the s character of boron relative to the CÀ B bond strongly decreases in the syn conformation, where X can participate as an electron donor to the empty p B orbital. Indeed, such interaction makes the syn conformation of 2-aminoethylborane the single stable conformer in the gas phase.

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