Antioxidant Actions of Thymoquinone, Silymarin, and Curcumin on Experimental Aortic Ischemia-Reperfusion Model in Wistar Albino Rats

Yardimci, Mustafa; Göz, Mustafa; Aydın, Mehmet Salih; Kankılıç, Nazım; Temiz, Ebru

doi:10.21470/1678-9741-2021-0462

Cited by 3 publications

(3 citation statements)

References 38 publications

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“…When the studies in the literature are examined, curcumin has shown many positive effects on TAS and TOS with its antioxidant properties [17,18] Consistent with the literature, TAS was found to be significantly lower in the curcumin group in our study (p=0.021). Although TOS was low in the curcumin group, it was not significantly different from other groups (p=0.069).…”

Section: Discussionsupporting

confidence: 89%

Protective effects of curcumin on kidney tissue in ischemia-reperfusion injury in rats

Sevil¹,

Sevil²,

Becit³

et al. 2023

Turk J Vasc Surg

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Aim: Kidney damage caused by ischemia-reperfusion (IR) is a serious clinical problem. Many studies have emphasized the antioxidant and anti-inflammatory properties of Curcumin. Material and Methods: Wistar-Albino male rats were divided into three groups. The sham group was the group in which only laparotomy was performed, the IR group was the group in which the infrarenal aorta was clamped after laparotomy and ischemia-reperfusion was created, and the IR+ curcumin group was the group in which intraperitoneal curcumin was given 1 hour before the procedure and the same procedures were repeated with the IR group. After creating the IR, blood and kidney tissue were taken from the rats and biochemical and histopathological examinations were performed. Results: Potassium (p=0.005), urea (p=0.050), and blood urea nitrogen (p=0.050) levels were higher in the IR+curcumin group. While total antioxidant status was found to be high in the IR+curcumin group (p=0.021), there was no difference in total oxidant status across the groups (p=0.069). Interleukin (IL)-1β and IL-6 were found to be higher in the IR group (p=0.014, p=0.022, respectively). Tumour necrosis factor-α was higher in the IR group than in other groups (p=0.020). Interferon-γ did not differ across groups (p=0.140). In the histopathological examination, the IR group had more damage to the glomerulus and tubular epithelial cells than the other groups (p<0.001). Conclusion: Curcumin, despite its anti-inflammatory and antioxidant characteristics, had no protective effect on renal functions in IR-induced kidney injury. It was found that it suppresses the inflammatory response and is effective in preserving renal tissue structure.

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Section: Discussionsupporting

confidence: 89%

Protective effects of curcumin on kidney tissue in ischemia-reperfusion injury in rats

Sevil¹,

Sevil²,

Becit³

et al. 2023

Turk J Vasc Surg

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“…In addition, TAS and TOS measurements did not improve in the silymarin-treated groups (S + CLP, CLP + S). This may indicate that the biochemical improvement reported in the literature (98,99) does not significantly contribute to tissue damage observed in sepsis.…”

Section: Discussionmentioning

confidence: 84%

“…In previous studies, silymarin and dexmedetomidine have been studied together with different combinations (98,(111)(112)(113)(114)(115)(116), but no study has been performed in which these two agents were used together. Thus, the present study aimed to investigate the effects of these two agents used together.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the efficacy of silymarin and dexmedetomidine on kidney and lung tissue in the treatment of sepsis in rats with cecal perforation

Yavuz,

Küçük,

Ergörün

et al. 2024

Exp Ther Med

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Sepsis is a systemic inflammatory response syndrome that develops in the host against microorganisms. This response develops away from the primary infection site and results in end-organ damage. The present study aimed to investigate the protective and therapeutic effects on lung and kidney tissue of silymarin (S) and dexmedetomidine (DEX) applied 1 h before and after sepsis induced by the cecal ligation and puncture (CLP) method in rats. A total of 62 rats was randomly divided into eight groups: i) Control (n=6); ii) cecal perforation (CLP; n=8); iii) S + CLP (n=8; S + CLP; S administered 1 h before CPL); iv) CLP + S (n=8; S administered 1 h after CLP); v) DEX + CLP (n=8; D + CLP; DEX administered 1 h before CLP); vi) CLP + D (n=8; DEX administered 1 h after CLP); vii) SD + CLP (n=8; S and DEX administered 1 h before CLP) and viii) CLP + SD (n=8; S and DEX administered 1 h after CLP). After the cecum filled with stool, it was tied with 3/0 silk under the ileocecal valve and the anterior surface of the cecum was punctured twice with an 18-gauge needle. A total of 100 mg/kg silymarin and 100 µg/kg DEX were administered intraperitoneally to the treatment groups. Lung and kidney tissue samples were collected to evaluate biochemical and histopathological parameters. In the histopathological examination, all parameters indicating kidney injury; interstitial edema, peritubular capillary dilatation, vacuolization, ablation of tubular epithelium from the basement membrane, loss of brush border in the proximal tubule epithelium, cell swelling and nuclear defragmentation; were increased in the CLP compared with the control group. Silymarin administration increased kidney damage, including ablation of tubular epithelium from the basement membrane, compared with that in the CLP group. DEX significantly reduced kidney damage compared with the CLP and silymarin groups. The co-administration of DEX + silymarin decreased kidney damage, although it was not as effective as DEX-alone. To conclude, intraperitoneal DEX ameliorated injury in CLP rats. DEX + silymarin partially ameliorated injury but silymarin administration increased damage. As a result, silymarin has a negative effects with this dosage and DEX has a protective effect. In the present study, it was determined that using the two drugs together had a greater therapeutic effect than silymarin and no differences in the effects were not observed any when the application times of the agents were changed.

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Synthesis, characterization, and toxicity assessments of Silymarin-loaded Ni-Fe Metal-organic frameworks: Evidence from in vitro and in vivo evaluations

Rahimi,

Shahraki,

Hajinezhad

et al. 2024

Journal of Drug Delivery Science and Technology

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Antioxidant Actions of Thymoquinone, Silymarin, and Curcumin on Experimental Aortic Ischemia-Reperfusion Model in Wistar Albino Rats

Cited by 3 publications

References 38 publications

Protective effects of curcumin on kidney tissue in ischemia-reperfusion injury in rats

Protective effects of curcumin on kidney tissue in ischemia-reperfusion injury in rats

Evaluation of the efficacy of silymarin and dexmedetomidine on kidney and lung tissue in the treatment of sepsis in rats with cecal perforation

Synthesis, characterization, and toxicity assessments of Silymarin-loaded Ni-Fe Metal-organic frameworks: Evidence from in vitro and in vivo evaluations

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