The Current Role of Surgery in the Treatment of Cardiac Metastases from Malignant Melanoma: an Educational Presentation

Abstract

A 71 year-old male with a history of multiple excisions of an initial Clark's level V melanoma of the breast followed by combined radiation and interferon treatment, as well as a recurrence, 3 years later, of a BRAF-positive tumor of the shoulder, with subsequent therapy with dabrafenib and trametinib, presented again with progressive intracardiac masses causing significant right ventricular outflow obstruction. Additionally, the patient complained of dyspnea and fatigue on exertion, thus he was scheduled for surgical resection.

Cardiac Metastatic Tumors

“…It is vital to take into consideration cardiac metastases in patients with melanoma if they present the symptoms discussed earlier. [39][40][41][42][43][44][45][46] Primary Neoplasms of the Heart Tumor lesions in the heart are usually metastatic and, when detected incidentally, prompt the search for a primary focus. When no other source of tumor cells can be detected on imaging evaluations, it is considered a primary cardiac lesion.…”

“…However, this topic definitely requires attention. It is vital to take into consideration cardiac metastases in patients with melanoma if they present the symptoms discussed earlier 39–46…”

Case report: A case report and literature review about Pathological transformation of lung adenosquamous cell carcinoma

“…A study published in the journal ANNALS OF ONCOLOGY further confirmed that EGFR-TKI is effective in treating ASC patients with EGFR mutation positive (1).For oligometastatic lesions during the period of first-line EGFR-TKI treatment, EGFR-TKI treatment can be continued and combined with local treatment. For patients of lung cancer with cardiac metastasis, through literature searching, local treatment, such as surgical resection or radiotherapy, has also got good outcome (28)(29)(30)(31).…”