Mean Platelet Volume-to-Platelet Count Ratio, Mean Platelet Volume-to-Lymphocyte Ratio, and Red Blood Cell Distribution Width-Platelet Count Ratio as Markers of Inflammation in Patients with Ascending Thoracic Aortic Aneurysm

Tekin, Yusuf Kenan; Tekin, Gülaçan

doi:10.21470/1678-9741-2019-0348

Cited by 10 publications

(2 citation statements)

References 23 publications

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“…Platelet function and activation is reflected by the MPV, and it could be used as a marker for inflammation [35]. The MPV is also a valuable marker in systemic inflammatory diseases and is thought to have a parallel correlation with CRP [36]. MPV levels have shown depressed levels during systemic inflammatory situations [37].…”

Section: Discussionmentioning

confidence: 99%

Which hematological markers have predictive value as early indicators of severe COVID-19 cases in the emergency department?

Şan¹,

Gemcioğlu²,

Davutoğlu³

et al. 2021

Turk J Med Sci

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IntroductionCoronavirus 2019 disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a pandemic infectious disease that causes morbidity and mortality. To date there are no proven diagnostic or prognostic parameters, but clinicians can use predictive parameters, such as the leukocyte and lymphocyte counts, C-reactive protein (CRP), D-dimer, and ferritin levels, and radiological imaging [1-3]. In the inflammation process of COVID-19, CRP, platelet, ferritin, and leukocyte values may increase, while albumin and lymphocyte values may decrease [4][5][6].White blood cells (WBCs), including neutrophils, lymphocytes, monocytes, have been used as inflammatory Background/aim: Coronavirus 2019 disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a pandemic infectious disease that causes morbidity and mortality. As a result of high mortality rate among the severe COVID-19 patients, the early detection of the disease stage and early effective interventions are very important in reducing mortality. Hence, it is important to differentiate severe and nonsevere cases from each other. To date, there are no proven diagnostic or prognostic parameters that can be used in this manner. Due to the expensive and not easily accessible tests that are performed for COVID-19, researchers are investigating some parameters that can be easily used. In some recent studies, hematological parameters have been evaluated to see if they can be used as predictive parameters. Materials and methods:In the current study, almost all hematological parameters were used, including the neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, monocyte/lymphocyte ratio, mean platelet volume to lymphocyte ratio, mean platelet volume to platelet ratio, plateletcrit, and D-dimer/fibrinogen ratio, neutrophil/lymphocyte/platelet scoring system, and systemic immune-inflammation index. A total of 750 patients, who were admitted to Ankara City Hospital due to COVID-19, were evaluated in this study. The patients were classified into 2 groups according to their diagnosis (confirmed or probable) and into 2 groups according to the stage of the disease (nonsevere or severe). Results:The values of the combinations of inflammatory markers and other hematological parameters in all of the patients with severe COVID-19 were calculated, and the predicted values of these parameters were compared. According to results of the study, nearly all of the hematological parameters could be used as potential diagnostic biomarkers for subsequent analysis, because the area under the curve (AUC) was higher than 0.50, especially for the DFR and NLR, which had the highest AUC among the parameters. Conclusion:Our findings indicate that, the parameters those enhanced from complete blood count, which is a simple laboratory test, can help to identify and classify COVID-19 patients into non-severe to severe groups.

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Section: Discussionmentioning

confidence: 99%

Which hematological markers have predictive value as early indicators of severe COVID-19 cases in the emergency department?

Şan¹,

Gemcioğlu²,

Davutoğlu³

et al. 2021

Turk J Med Sci

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“…We read with great interest the retrospective study by Tekin and Tekin related to mean platelet volume (MPV), MPV to platelet count ratio and MPV to lymphocyte ratio in patients with ascending thoracic aortic aneurysm 1 . Based on the results of the study, the researchers suggested that these parameters will contribute to the diagnosis of ascending thoracic aortic aneurysm and will guide the evaluating physician in terms of the need for additional imaging studies.…”

mentioning

confidence: 99%

Mean Platelet Volume and Related Parameters May not Contribute to the Diagnosis in Patients with Ascending Thoracic Aortic Aneurysm

Beyan¹,

Beyan²

2020

Braz J Cardiovasc Surg

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Human acute inflammatory recovery is defined by co-regulatory dynamics of white blood cell and platelet populations

et al. 2022

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Inflammation is the physiologic reaction to cellular and tissue damage caused by trauma, ischemia, infection, and other pathologic conditions. Elevation of white blood cell count (WBC) and altered levels of other acute phase reactants are cardinal signs of inflammation, but the dynamics of these changes and their resolution are not well established. Here we studied inflammatory recovery from trauma, ischemia, and infection by tracking longitudinal dynamics of clinical laboratory measurements in hospitalized patients. We identified a universal recovery trajectory defined by exponential WBC decay and delayed linear growth of platelet count (PLT). Co-regulation of WBC-PLT dynamics is a fundamental mechanism of acute inflammatory recovery and provides a generic approach for identifying high-risk patients: 32x relative risk (RR) of adverse outcomes for cardiac surgery, 9x RR of death from COVID-19, 9x RR of death from sepsis, and 5x RR of death from myocardial infarction.

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Mean Platelet Volume-to-Platelet Count Ratio, Mean Platelet Volume-to-Lymphocyte Ratio, and Red Blood Cell Distribution Width-Platelet Count Ratio as Markers of Inflammation in Patients with Ascending Thoracic Aortic Aneurysm

Cited by 10 publications

References 23 publications

Which hematological markers have predictive value as early indicators of severe COVID-19 cases in the emergency department?

Which hematological markers have predictive value as early indicators of severe COVID-19 cases in the emergency department?

Mean Platelet Volume and Related Parameters May not Contribute to the Diagnosis in Patients with Ascending Thoracic Aortic Aneurysm

Human acute inflammatory recovery is defined by co-regulatory dynamics of white blood cell and platelet populations

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