Human acute inflammatory recovery is defined by co-regulatory dynamics of white blood cell and platelet populations

Foy, Brody H.; Sundt, Thoralf M.; Carlson, Jonathan C.; Aguirre, Aaron D.; Higgins, John M.

doi:10.1038/s41467-022-32222-2

Cited by 26 publications

(14 citation statements)

References 24 publications

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“… 75 All these beneficial effects are thought to be modulated by the same inflammatory pathways involved in acute/chronic inflammation and pain. 76 In other words, a controlled increase of inflammatory mediators after an acute bout of exercise would be an allostatic mechanism to allow the body to adapt to a subsequent physical challenge with potential beneficial effects in the longer term. The widespread belief that only reductions in inflammatory mediators expression represent healthy change ignores the nuance of the complex role that physiological inflammation plays in maintaining homeostasis and dynamically adapting to an evolving environment.…”

Section: Discussionmentioning

confidence: 99%

The Effects of a Single Bout of High- or Moderate-Intensity Yoga Exercise on Circulating Inflammatory Mediators: A Pilot Feasibility Study

Muñoz-Vergara

Schreiber

Langevin

et al. 2022

Glob Adv Health Med

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Background There is a knowledge gap in the physiological effects of short-term yoga exercise interventions. Objective To evaluate the feasibility of a randomized controlled trial (RCT) assessing the acute effects of a yoga exercise protocol practiced at 2 intensities (high or moderate) on temporal responses of a battery of systemic circulatory cytokines in healthy yoga-naïve adults. Methods This study was a three-arm, pre-post pilot-RCT employing a single bout of yoga exercise intervention. Groups were high-intensity yoga (HY, n = 10), moderate-intensity yoga (MY, n = 10), and a sedentary, no-intervention control group (CON, n = 10). Blood samples were collected at baseline and post-intervention at 6 timepoints (0-, 30-, 60-, 120-, 180-minutes, and 24-hours post-intervention) and were processed with a pre-defined inflammatory panel of 13 cytokines. Heart rate (HR) was assessed with a Polar H10® device. The PROMIS Pain intensity Questionnaire was used to assess body soreness. Results We demonstrate feasibility of recruitment, randomization, and retention of participants based upon predetermined metrics, including: proportion of eligible to enrolled participants (55%); recruitment period (11-months); participant retention (97%); completion rate for questionnaires (99%); completion of physiological measures (98%); and adherence to the yoga exercise protocol (88%). Cytokine levels over time were heterogeneous within and between groups. Responses of a subset of cytokines were positively correlated with 1 another in high- and moderate-intensity yoga exercise groups but not in the control group. Median values for HR were 91 (IQR: 71–95) in the HY, 95 (IQR: 88–100) in the MY, and 73 (IQR: 72–75) in the CON. Pre-post changes in body soreness after the yoga exercise intervention were most evident in the HY group. Conclusion Along with observed trends in select cytokines, findings encourage a more definitive trial aimed at understanding the short-term effects of yoga exercise on inflammatory immune markers and pain in sedentary healthy adults. Clinicaltrials.gov ID# NCT04444102.

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Section: Discussionmentioning

confidence: 99%

The Effects of a Single Bout of High- or Moderate-Intensity Yoga Exercise on Circulating Inflammatory Mediators: A Pilot Feasibility Study

Muñoz-Vergara

Schreiber

Langevin

et al. 2022

Glob Adv Health Med

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“…Nevertheless, there is indisputable that the dynamic change of the blood cells has significant prognostic value in AMI. Foy et al ( 36 ) have identified a universal recovery trajectory defined by exponential WBC decay and delayed linear growth of PLT, which provides a generic approach for identifying high-risk patients with acute inflammatory diseases, including AMI. It means that the CBC w/diff test has more prognostic value to be developed in the future.…”

Section: Discussionmentioning

confidence: 99%

Development of a complete blood count with differential—based prediction model for in-hospital mortality among patients with acute myocardial infarction in the coronary care unit

Wang

Miao

et al. 2022

Front. Cardiovasc. Med.

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PurposeIn recent years, the complete blood count with differential (CBC w/diff) test has drawn strong interest because of its prognostic value in cardiovascular diseases. We aimed to develop a CBC w/diff-based prediction model for in-hospital mortality among patients with severe acute myocardial infarction (AMI) in the coronary care unit (CCU).Materials and methodsThis single-center retrospective study used data from a public database. The neural network method was applied. The performance of the model was assessed by discrimination and calibration. The discrimination performance of our model was compared to that of seven other classical machine learning models and five well-studied CBC w/diff clinical indicators. Finally, a permutation test was applied to evaluate the importance rank of the predictor variables.ResultsA total of 2,231 patient medical records were included. With a mean area under the curve (AUC) of 0.788 [95% confidence interval (CI), 0.736–0.838], our model outperformed all other models and indices. Furthermore, it performed well in calibration. Finally, the top three predictors were white blood cell count (WBC), red blood cell distribution width-coefficient of variation (RDW-CV), and neutrophil percentage. Surprisingly, after dropping seven variables with poor prediction values, the AUC of our model increased to 0.812 (95% CI, 0.762–0.859) (P < 0.05).ConclusionWe used a neural network method to develop a risk prediction model for in-hospital mortality among patients with AMI in the CCU based on the CBC w/diff test, which performed well and would aid in early clinical decision-making. The top three important predictors were WBC, RDW-CV and neutrophil percentage.

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“…Patients with COVID-19 have elevated neutrophils and lower lymphocytes due to an inflammatory immune response to the viral infection. In addition, platelets produce related inflammatory factors, which have an important role in regulating immunity and inflammation during the disease ( 35 ). Therefore, derivatives of white blood cell subsets and platelets, dNLR, NLR, and SII could be relevant predictive parameters of COVID-19 Omicron BA.2 infection.…”

Section: Discussionmentioning

confidence: 99%

The derived neutrophil to lymphocyte ratio can be the predictor of prognosis for COVID-19 Omicron BA.2 infected patients

et al. 2022

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BackgroundSeveral systemic inflammatory biomarkers have been associated with poor overall survival (OS) and disease severity in patients with coronavirus disease 2019 (COVID-19). However, it remains unclear which markers are better for predicting prognosis, especially for COVID-19 Omicron BA.2 infected patients. The present study aimed to identify reliable predictors of prognosis of COVID-19 Omicron BA.2 from inflammatory indicators.MethodsA cohort of 2645 COVID-19 Omicron BA.2 infected patients were retrospectively analyzed during the Omicron BA.2 surge in Shanghai between April 12, 2022, and June 17, 2022. The patients were admitted to the Shanghai Fourth People’s Hospital, School of Medicine, Tongji University. Six systemic inflammatory indicators were included, and their cut-off points were calculated using maximally selected rank statistics. The analysis involved Kaplan-Meier curves, univariate and multivariate Cox proportional hazard models, and time-dependent receiver operating characteristic curves (time-ROC) for OS-associated inflammatory indicators.ResultsA total of 2347 COVID-19 Omicron BA.2 infected patients were included. All selected indicators proved to be independent predictors of OS in the multivariate analysis (all P < 0.01). A high derived neutrophil to lymphocyte ratio (dNLR) was associated with a higher mortality risk of COVID-19 [hazard ratio, 4.272; 95% confidence interval (CI), 2.417-7.552]. The analyses of time-AUC and C-index showed that the dNLR (C-index: 0.844, 0.824, and 0.718 for the 5th, 10th, and 15th day, respectively) had the best predictive power for OS in COVID-19 Omicron BA.2 infected patients. Among different sub-groups, the dNLR was the best predictor for OS regardless of age (0.811 for patients aged ≥70 years), gender (C-index, 0.880 for men and 0.793 for women) and disease severity (C-index, 0.932 for non-severe patients and 0.658 for severe patients). However, the platelet to lymphocyte ratio was superior to the other indicators in patients aged <70 years.ConclusionsThe prognostic ability of the dNLR was higher than the other evaluated inflammatory indicators for all COVID-19 Omicron BA.2 infected patients.

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Human acute inflammatory recovery is defined by co-regulatory dynamics of white blood cell and platelet populations

Cited by 26 publications

References 24 publications

The Effects of a Single Bout of High- or Moderate-Intensity Yoga Exercise on Circulating Inflammatory Mediators: A Pilot Feasibility Study

The Effects of a Single Bout of High- or Moderate-Intensity Yoga Exercise on Circulating Inflammatory Mediators: A Pilot Feasibility Study

Development of a complete blood count with differential—based prediction model for in-hospital mortality among patients with acute myocardial infarction in the coronary care unit

The derived neutrophil to lymphocyte ratio can be the predictor of prognosis for COVID-19 Omicron BA.2 infected patients

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