Clinical Significance of Cys-C and hs-CRP in Coronary Heart Disease Patients Undergoing Percutaneous Coronary Intervention

Abstract

Objective To investigate the clinical significance of serum cystatin C (Cys-C) and high-sensitivity C-reactive protein (hs-CRP) in coronary heart disease (CHD) patients undergoing percutaneous coronary intervention (PCI). Methods One hundred and twenty-eight CHD patients were divided into drug treatment (56 cases) and PCI treatment (72 cases) groups, receiving conventional drug treatment and PCI plus conventional drug treatment, respectively. At admission time and 4 weeks after treatment, the left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter, and left ventricular end systolic diameter were measured. At admission time and 24h, 72h, 1 week, and 4 weeks after treatment, the serum levels of Cys-C and hs-CRP were determined. Results After 4 weeks of treatment, LVEF in the PCI treatment group was significantly higher than that before treatment ( P <0.01) and it was significantly higher than in the drug treatment group at the same time ( P <0.01). Cys-C and hs-CRP level in the PCI treatment group were significantly higher than in the drug treatment group 72h and 1 week after treatment ( P <0.05 or P <0.01), respectively, but they were significantly lower than in the drug treatment group 4 weeks after treatment ( P <0.01). There were obvious interaction effects between grouping factor and time factor in Cys-C (F=3.62, P <0.05) and hs-CRP (F=17.85, P <0.01). Conclusion Serum levels of Cys-C and hs-CRP are closely related to the heart function in CHD patients undergoing PCI, and they may be used for predicting the outcome of PCI.

A New Perspective for Isolated Coronary Artery Ectasia: Cystatin C

“…This may be because of the patients with high hs-CRP levels who were excluded from the study. Therewith, our results were complementary to previous studies [ 23 - 24 ].…”

Correlation of osteoprotegerin, sRANKL, inflammatory factors and epicardial adipose tissue volume with coronary heart disease

“…OPG is closely related to bone metabolism and belongs to an important vascular regulatory factor, which is expressed and released by vascular smooth muscle cells and vascular endothelial cells in the form of active dimers, and is closely related to the occurrence and development of atherosclerosis and arterial calcification. 17 Hs-CRP is a sensitive acute-phase response protein synthesised by the liver, and its content is extremely low under normal conditions. When acute inflammation, infarction or trauma occurs in the body, the level of hs-CRP will continue to rise, which can be used as an im- substance of high-concentration plasmin but also the substrate of thrombin, and plays an important role in the fibrinolytic system and coagulation system.…”

The Role Of hs-CRP In Predicting The Likelihood Of Coronary Heart Disease

“…In patients proven to have coronary lesions, ST-T segment abnormalities are associated with disease severity. Other non-invasive tests that can be performed are cardiac training, myocardial perfusion imaging, stress echocardiography, cardiac CT-scans, and cardiac magnetic resonance imaging [9,12,13].…”

“…However, the CAG examination method is invasive, which requires time and ability to assess the severity of coronary anatomy. Coronary angiography has 2 main objectives, namely to assess the risk of cardiovascular events and death of the patient and help determine the choice of revascularization therapy [12,13]. Biomarker indicators for predicting ISR have become the main focus in the academic and research fields.…”

“…), can also be used as independent risk factors to assess CHD and are closely related to cardiovascular events. hs-CRP is a marker of inflammation, which is synthesized by the liver which can be used to predict the risk of cardiovascular disease especially CHD [12,14].…”