Nutritional genomics, inflammation and obesity

Corrêa, Telma Angelina Faraldo; Quintanilha, Bruna Jardim; Norde, Marina Maintinguer; Pinhel, Marcela Augusta de Souza; Nonino, Carla Barbosa; Rogero, Marcelo Macedo

doi:10.20945/2359-3997000000255

Cited by 17 publications

(16 citation statements)

References 146 publications

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“…It turned out that obesity would be confusing the relation between IL-6 and nickel, by increasing the influence of nickel in the inflammatory status of individuals in over 40% (from 25% to 36%) when including BMI in the model. This is not rare, since obese people are proven to have a permanent increased inflammatory status [28]. On the other hand, the relation between metals and glycemia did not change much when including BMI in the regression model, neither with cholesterol.…”

Section: Findings Of This Studymentioning

confidence: 94%

A Positive Relationship between Exposure to Heavy Metals and Development of Chronic Diseases: A Case Study from Chile

Cortés

Zúñiga-Venegas

Pancetti

et al. 2021

IJERPH

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Chile is a mining country, where waste mining is frequently found in the vicinity of inhabited areas. To explore the association between metal exposure and alterations in glucose metabolism, inflammatory status, and oxidative stress in individuals with chronic exposure to metals, a cross-sectional study was performed with 25 volunteers, between 45–65 years old. Inductive coupled plasma mass spectrometry (ICP-MS) was used to measure urinary levels of total arsenic (As) and its metabolites, cooper, nickel, chromium, and lead. Lipid profile, glucose, and insulin were measured in blood, as well as inflammation (interleukin-6, IL-6) and oxidative stress (8-hydroxy-2′deoxyguanosine, 8-OHdG) markers. Increased levels of Low-density lipoprotein, high-density lipoproteins, cholesterol and 8-OHdG, and the index for homeostasis model assessment—insulin resistance (HOMA-IR) were observed in 72%, 60%, and 56% of the volunteers, respectively. Blood-glucose levels were correlated with dimethylarsinic acid (DMA) (R2 = 0.47, p = 0.019), inorganic As (Asi) (R2 = 0.40, p = 0.012), and Ni (R2 = 0.56; p = 0.044). The models with these compounds explained 72% of the glycemia variability (βDMA = −6.47; βAsi = 6.68; βNi = 6.87). Ni showed a significantly influence on IL-6 variability (β = 0.85: R2 = 0.36). Changes in glycemia could be related to exposure to low levels of Asi and Ni, representing risk factors for metabolic diseases. Body mass index would confuse the relation between IL-6 and Ni levels, probably due to known chronic inflammation present in obese people.

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Section: Findings Of This Studymentioning

confidence: 94%

A Positive Relationship between Exposure to Heavy Metals and Development of Chronic Diseases: A Case Study from Chile

Cortés

Zúñiga-Venegas

Pancetti

et al. 2021

IJERPH

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“…Current research shows a link between changes in inflammatory profile and the risk of several chronic conditions, including metabolic syndrome, type 2 diabetes mellitus, and CVDs [ 86 , 87 , 88 ]. Interestingly, the high-flavonol diet was related to a decrease in urinary isoprostanes, which is a well-known marker of oxidative stress [ 89 ].…”

Section: Clinical Studies On Flavanol Interventions—an Update From Th...mentioning

confidence: 99%

Targeting Cardiovascular Diseases by Flavonols: An Update

Kozłowska

Szostak-Węgierek

2022

Nutrients

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Flavonols are one of the most plentiful flavonoid subclasses found in natural products and are extensively used as dietary supplements. Numerous in vitro and in vivo studies have shown the cardioprotective properties of flavonols, especially quercetin. This group of substances exerts positive impacts primarily due to their antiatherogenic, antithrombotic, and antioxidant activities. The potential of flavonols to promote vasodilation and regulation of apoptotic processes in the endothelium are other beneficial effects on the cardiovascular system. Despite promising experimental findings, randomized controlled trials and meta-analyses have yielded inconsistent results on the influence of these substances on human cardiovascular parameters. Thus, this review aims to summarize the most recent clinical data on the intake of these substances and their effects on the cardiovascular system. The present study will help clinicians and other healthcare workers understand the value of flavonol supplementation in both subjects at risk for cardiovascular disease and patients with cardiovascular diseases.

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“…These data are essential to find out how obesity is outlined and impacts on the emerging metabolic disorders. The diet lipid content profile can modulate pro-inflammatory genes expression (34). Prolonged consumption of a high-fat diet promotes an increase in inflammatory mediators in the central nervous system and peripheral tissues including liver and adipose tissue (35).…”

Section: Dietary Imbalance and Inflammation: From The Gut To The Brainmentioning

confidence: 99%

The Transition From Undernutrition to Overnutrition Under Adverse Environments and Poverty: The Risk for Chronic Diseases

et al. 2021

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Nutritional genomics, inflammation and obesity

Cited by 17 publications

References 146 publications

A Positive Relationship between Exposure to Heavy Metals and Development of Chronic Diseases: A Case Study from Chile

A Positive Relationship between Exposure to Heavy Metals and Development of Chronic Diseases: A Case Study from Chile

Targeting Cardiovascular Diseases by Flavonols: An Update

The Transition From Undernutrition to Overnutrition Under Adverse Environments and Poverty: The Risk for Chronic Diseases

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