Decreased serum levels of IL-27and IL-35 in patients with Graves disease

Saeed, Malek-Hosseini; Kalantar, Kurosh; Zahra, Amirghofran; Hossein, Dabbaghmanesh Mohamad; Rostamzadeh, Davoud; Ataollahi, Mohammad Reza

doi:10.20945/2359-3997000000227

Cited by 14 publications

(11 citation statements)

References 35 publications

(40 reference statements)

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“…In addition, some studies show that antithyroid drugs can reduce the production of thyroid pro‐inflammatory cytokines 4 . An increasing number of studies have suggested that pro‐inflammatory cytokines, such as interleukin (IL)‐35, IL‐29, IL‐27, and tumor necrosis factor (TNF)‐α, may be involved in the development of GD 5–8 …”

Section: Introductionmentioning

confidence: 99%

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Low serum interleukin‐38 levels in patients with Graves’ disease and Hashimoto’s thyroiditis

Huang

Weng

et al. 2021

Clinical Laboratory Analysis

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Background Autoimmune thyroid disease (AITD) mainly includes Graves’ disease (GD) and Hashimoto's thyroiditis (HT), which is caused by individual genetics, autoimmune dysfunction, and a variety of external environmental factors. Interleukin (IL)‐38 is involved in a wide range of autoimmune diseases, but little is known about IL‐38 expression in AITD. Methods Fifty patients with GD, 50 with HT, and 50 healthy controls (HC) were enrolled in this study. Basic information of the participants was obtained through a physical examination. Immunological data were obtained by an automatic chemiluminescence immunoanalyzer. C‐reactive protein (CRP) concentrations and the white blood cell count were measured. Serum IL‐38 levels were determined by an enzyme‐linked immunosorbent assay. Results Serum IL‐38 levels were significantly lower in the GD and HT groups than in the HC group (both p < 0.01). Serum CRP concentrations were significantly lower in the HT group than in the HC group (p < 0.05). Receiver operating characteristic curve analysis showed that the area under the curve was 0.7736 (p < 0.01) for IL‐38 and 0.7972 (p < 0.01) for IL‐38 combined with CRP in the GD group. In the HT group, the area under the curve was 0.7276 (p < 0.01) for IL‐38 and 0.7300 for IL‐38 combined with CRP (p < 0.01). Conclusions The results suggest that serum IL‐38 level is a potential new diagnostic biomarker in patients with GD and HT.

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Section: Introductionmentioning

confidence: 99%

“… 4 An increasing number of studies have suggested that pro‐inflammatory cytokines, such as interleukin (IL)‐35, IL‐29, IL‐27, and tumor necrosis factor (TNF)‐α, may be involved in the development of GD. 5 , 6 , 7 , 8 …”

Section: Introductionmentioning

confidence: 99%

Low serum interleukin‐38 levels in patients with Graves’ disease and Hashimoto’s thyroiditis

Huang

Weng

et al. 2021

Clinical Laboratory Analysis

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“…GWAS genes in the modules associated with these traits were enriched for lymphocyte activation and differentiation and TCR signaling and cell-cell adhesion (e.g., PTPRC, IL2RA, IL7R, IFNG, FASLG, Figure 6E), with IL-35 signaling genes enriched in hypothyroidism and IBD, consistent with IL-35 upregulation in Hashimoto's thyroiditis (Yilmaz et al, 2016) and IBD (Y. Li et al, 2014)) and downregulation in Graves' disease (Saeed et al, 2021). The cardiovascular traits group included hypertension, atrial fibrillation, mean arterial pressure and renin-angiotensin system, was associated with pericytes/smooth muscle cells (SMCs, responsible for modulating total peripheral resistance in arterioles), and was enriched with blood circulation, smooth muscle contraction, muscle structure development and cardiocyte differentiation genes (e.g., CACNA1C, CACNA1D, CASQ2, PLN).…”

Section: Associating Gwas Genes With Gene Programs Across Cell Types Reveals Six Main Trait Groupsmentioning

confidence: 68%

Single-nucleus cross-tissue molecular reference maps to decipher disease gene function

Eraslan

Drokhlyansky

Anand

et al. 2021

Preprint

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Understanding the function of genes and their regulation in tissue homeostasis and disease requires knowing the cellular context in which genes are expressed in tissues across the body. Single cell genomics allows the generation of detailed cellular atlases in human tissues, but most efforts are focused on single tissue types. Here, we establish a framework for profiling multiple tissues across the human body at single-cell resolution using single nucleus RNA-Seq (snRNA-seq), and apply it to 8 diverse, archived, frozen tissue types (three donors per tissue). We apply four snRNA-seq methods to each of 25 samples from 16 donors, generating a cross-tissue atlas of 209,126 nuclei profiles, and benchmark them vs. scRNA-seq of comparable fresh tissues. We use a conditional variational autoencoder (cVAE) to integrate an atlas across tissues, donors, and laboratory methods. We highlight shared and tissue-specific features of tissue-resident immune cells, identifying tissue-restricted and non-restricted resident myeloid populations. These include a cross-tissue conserved dichotomy between LYVE1- and HLA class II-expressing macrophages, and the broad presence of LAM-like macrophages across healthy tissues that is also observed in disease. For rare, monogenic muscle diseases, we identify cell types that likely underlie the neuromuscular, metabolic, and immune components of these diseases, and biological processes involved in their pathology. For common complex diseases and traits analyzed by GWAS, we identify the cell types and gene modules that potentially underlie disease mechanisms. The experimental and analytical frameworks we describe will enable the generation of large-scale studies of how cellular and molecular processes vary across individuals and populations.

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“…Our data suggest a possible detrimental effect of IL-27, which is likely to contribute to the development of autoimmune thyroid disease in individuals with T1DM. In contrast, a recent study found reduced IL-27 serum levels in patients with Graves' disease, suggesting a possible anti-inflammatory role of these cytokines [46]. A possible explanation for these differences is the effect of IL-27 on the Th1 to Th2 ratio [47], which is dominant in HD, whereas it is non-dominant in Graves' disease [48].…”

Section: Discussionmentioning

confidence: 86%

Sirtuin 1, Visfatin and IL-27 Serum Levels of Type 1 Diabetic Females in Relation to Cardiovascular Parameters and Autoimmune Thyroid Disease

et al. 2021

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The loss of cardioprotection observed in premenopausal, diabetic women may result from the interplay between epigenetic, metabolic, and immunological factors. The aim of this study was to evaluate the concentration of sirtuin 1, visfatin, and IL-27 in relation to cardiovascular parameters and Hashimoto’s disease (HD) in young, asymptomatic women with type 1 diabetes mellitus (T1DM). Thyroid ultrasound, carotid intima-media thickness (cIMT) measurement, electrocardiography, and echocardiography were performed in 50 euthyroid females with T1DM (28 with HD and 22 without concomitant diseases) and 30 controls. The concentrations of serum sirtuin 1, visfatin and IL-27 were assessed using ELISA. The T1DM and HD group had higher cIMT (p = 0.018) and lower left ventricular global longitudinal strain (p = 0.025) compared to females with T1DM exclusively. In women with a double diagnosis, the sirtuin 1 and IL-27 concentrations were non-significantly higher than in other groups and significantly positively correlated with each other (r = 0.445, p = 0.018) and thyroid volume (r = 0.511, p = 0.005; r = 0.482, p = 0.009, respectively) and negatively correlated with relative wall thickness (r = –0.451, p = 0.016; r = –0.387, p = 0.041, respectively). These relationships were not observed in the control group nor for the visfatin concentration. These results suggest that sirtuin 1 and IL-27 contribute to the pathogenesis of early cardiac dysfunction in women with T1DM and HD.

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Decreased serum levels of IL-27and IL-35 in patients with Graves disease

Cited by 14 publications

References 35 publications

Low serum interleukin‐38 levels in patients with Graves’ disease and Hashimoto’s thyroiditis

Low serum interleukin‐38 levels in patients with Graves’ disease and Hashimoto’s thyroiditis

Single-nucleus cross-tissue molecular reference maps to decipher disease gene function

Sirtuin 1, Visfatin and IL-27 Serum Levels of Type 1 Diabetic Females in Relation to Cardiovascular Parameters and Autoimmune Thyroid Disease

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