Waist circumference is an effect modifier of the association between bone mineral density and glucose metabolism

Barroso, Lygia N.; Farias, Dayana Rodrigues; Soares-Mota, Márcia; Bettiol, Heloísa; Barbieri, Marco Antônio; Foss, Milton César; Silva, Antônio Augusto Moura da; Kac, Gilberto

doi:10.20945/2359-3997000000040

Cited by 4 publications

(4 citation statements)

References 34 publications

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“…The consequences of PRL levels in PCOS patients showed a significant decline after excluding the influence of age and BMI (P < 0.001), compared with non-PCOS patients (exhibiting oviductal infertility). As a clinical diagnostic standard of central obesity, WC reflects the addition of visceral and abdominal fat, which can predict obesity-related health risk and provide a key risk factor for metabolic syndrome (MS) involving the onset of insulin resistance (32)(33)(34). In addition, as an insulin resistancerelated risk factor, serum PRL levels were found to have an inverse association with WC, similar to results for PCOS or hypertrichosis patients (23,24).…”

Section: Discussionsupporting

confidence: 56%

Prolactin Is Associated With Insulin Resistance and Beta-Cell Dysfunction in Infertile Women With Polycystic Ovary Syndrome

Yang

Lin

et al. 2021

Front. Endocrinol.

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BackgroundOur study aimed to investigate if serum prolactin (PRL) levels associated with insulin resistance and beta-cell dysfunction in infertile patients with polycystic ovary syndrome (PCOS).MethodsThis was a retrospective cross-sectional study performed in the reproductive medicine center of the first affiliated hospital of Wenzhou Medical University. From January 2007 to August 2018, a total of 792 PCOS and 700 non-PCOS infertile women were included. All patients’ prolactin levels were in the normal range. PCOS was diagnosed according to the Rotterdam Criteria. Anthropometric parameters, blood pressure, serum prolactin levels, sex hormones, fasting lipids, fasting plasma glucose (FPG), fasting insulin (FINS) and hepatic biological parameters were measured in all subjects.ResultsSerum prolactin levels in PCOS women were significantly decreased compared with levels in non-PCOS women after adjusting for age and BMI (P < 0.05). Moreover, we found that prolactin levels were positively associated with high-density lipoprotein cholesterol (HDL-C) and negatively associated with age, BMI, waist circumference (WC), hip circumference (HC), luteinizing hormone/follicle stimulating hormone (LH/FSH), estradiol (E2), FINS, homeostasis model assessment of insulin resistance (HOMA-IR), homeostasis model assessment of β (HOMA-β), triglyceride (TG) and alanine aminotransferase (ALT) (P < 0.05). After adjusting for age and BMI, multiple linear regression analysis revealed that LH, LH/FSH, E2, FINS, HOMA-IR, and HOMA-β were negatively associated with serum PRL (P < 0.05).ConclusionsLow serum PRL levels within the normal range associates with a higher incidence of insulin resistance and beta-cell dysfunction in infertile women with PCOS.

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Section: Discussionsupporting

confidence: 56%

Prolactin Is Associated With Insulin Resistance and Beta-Cell Dysfunction in Infertile Women With Polycystic Ovary Syndrome

Yang

Lin

et al. 2021

Front. Endocrinol.

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“…2 Currently, it has been recognized that patients with T2DM were associated with higher risk of fractures than non-diabetic patients, 3 BMD was associated with glucose metabolism. 4,5 Another study has also revealed the differences in the blood glucose levels among osteoporosis, low BMD, and normal BMD groups. 6 However, there was a study showed the detection rates of low BMD and osteoporosis have no significant differences among different glucose metabolism groups.…”

Section: Introductionmentioning

confidence: 99%

<p>Relationship of Two-Hour Plasma Glucose and Abdominal Visceral Fat with Bone Mineral Density and Bone Mineral Content in Women with Different Glucose Metabolism Status</p>

Jia¹,

Liu²,

Wu³

et al. 2020

DMSO

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Background: Several studies have reported the relationship of diabetes mellitus (DM) and obesity with bone mineral density (BMD), but the conclusions remain unclear. This study aimed to provide more information for the relationship of plasma glucose and abdominal visceral fat (AVF) with BMD and bone mineral content (BMC) in women with different glucose metabolism status. Methods: Patients were screened by oral glucose tolerance test (OGTT) and were divided into three groups: normal glucose tolerance (NGT, n=132), pre-diabetes mellitus (pre-DM, n=28) and newly diagnosed type 2 DM (T2DM, n=27) groups. Plasma glucose concentrations, anthropometric measurements, body composition, and BMD were measured. Analysis of variance (ANOVA), pearson correlation, and multiple linear regression models were used to evaluate the relationship between BMD, plasma glucose, AVF, and other variables. Results: The percentage of subjects with osteoporosis or low BMD was 29.9%, and 66.7% subjects in T2DM group were significantly higher than that in the pre-DM (28.6%) and NGT (22.7%) groups (p=0.005 and p<0.001, respectively). Both BMD at femoral neck (FN) and lumbar spine (LS) of T2DM group were lower than those in NGT group (p=0.009 and p=0.003, respectively), and BMC of T2DM group was lower than those of NGT and pre-DM groups (p<0.001). The results of statistical analysis revealed that both two-hour plasma glucose (2-h PG) and age showed negative correlation with BMC, FN BMD, and LS BMD. AVF showed positive correlation with BMC and LS BMD. Furthermore, the lean mass (LM) showed independent positive effects on BMC. Conclusion: Our findings suggest that 1) Age is a strong negative predictor of bone mass. 2) A direct negative effect of increasing 2-h PG might be more prominent at bone mass in women. 3) A moderate increase in AVF is beneficial to bone mass, while excessive increase might be harmful. 4) LM is a positive predictor of BMC.

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“…The effect of obesity on osteoporosis remained controversial [2,3]. The majority of studies have suggested that obesity had a protective effect against excessive bone loss with aging [4,5] which may be due to material stimulation during bone formation [6,7] and the physical protection provided by the adipose tissue, thus preventing accidental fall-induced fractures [4,8]. In contrast to the studies mentioned above, others have reported a negative impact of obesity on skeletal health [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Diabetes Mellitus Type 2 Patients with Abdominal Obesity Are Prone to Osteodysfunction: A Cross-Sectional Study

Guo

Wang

et al. 2023

Journal of Diabetes Research

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Introduction. The interaction between diabetes, obesity, and bone metabolism was drawing increasing public attention. However, the osteometabolic changes in diabetes mellitus type 2 (T2DM) patients with abdominal obesity have not been fully revealed. This study is aimed at investigating the association between abdominal obesity indices and bone turnover markers among T2DM participants. Methods. 4351 subjects were involved in the METAL study. Abdominal obesity indices included neck, waist, and hip circumference, visceral adiposity index (VAI), lipid accumulation product (LAP), waist-to-hip ratio (WHR), and Chinese visceral adiposity index (CVAI). They were applied to elucidate the nexus between β-C-terminal telopeptide (β-CTX), osteocalcin (OC), and intact N-terminal propeptide of type I collagen (P1NP). Results. Abdominal obesity indices were strongly negatively associated with β-CTX and OC. Among males, five indices were negatively correlated with β-CTX (BMI, WC, LAP, WHR, and CVAI) and OC (BMI, NC, WC, WHR, and CVAI). There were no significant associations with P1NP. Among females, all eight indices were negatively associated with β-CTX. Seven indices were negatively related to OC (BMI, NC, WC, HC, LAP, WHR, and CVAI). The VAI was negatively correlated with P1NP. Conclusions. The present study demonstrated that in T2DM, abdominal obesity had an obviously negative correlation with bone metabolism. Abdominal obesity indices were significantly negatively associated with skeletal destruction (β-CTX) and formation (OC). In routine clinical practice, these easily obtained indices could be used as a preliminary screening method and relevant factors for osteodysfunction incidence risk at no additional cost and may be of particular value for postmenopausal women in T2DM populations.

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Waist circumference is an effect modifier of the association between bone mineral density and glucose metabolism

Abstract: BMD was associated with glucose metabolism, independently of OC, and WC modifies this association.

Cited by 4 publications

References 34 publications

Prolactin Is Associated With Insulin Resistance and Beta-Cell Dysfunction in Infertile Women With Polycystic Ovary Syndrome

Prolactin Is Associated With Insulin Resistance and Beta-Cell Dysfunction in Infertile Women With Polycystic Ovary Syndrome

<p>Relationship of Two-Hour Plasma Glucose and Abdominal Visceral Fat with Bone Mineral Density and Bone Mineral Content in Women with Different Glucose Metabolism Status</p>

Diabetes Mellitus Type 2 Patients with Abdominal Obesity Are Prone to Osteodysfunction: A Cross-Sectional Study

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