Triclosan antimicrobial activity against dental-caries-related bacteria

Farias, Jade Ormondes de; Santo, Jamilca de Almeida do Espírito; Amorim, Ingrid Aquino; Rezende, Taia Maria Berto

doi:10.20396/bjos.v22i00.8668076

Cited by 2 publications

(2 citation statements)

References 22 publications

(34 reference statements)

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“…Triclosan has antibacterial properties, including activity against Streptococcus mutans [ 9 , 28 ]. However, in recent years, there has been controversy about its safety [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Prevention of Dental Caries: A Review on the Improvements of Toothpaste Formulations from 1900 to 2023

Unterbrink,

Schulze zur Wiesche,

Meyer

et al. 2024

Dentistry Journal

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Modern toothpastes are complex formulations with various ingredients. The aim of this study was to analyze the improvement of toothpaste formulations from 1900 to 2023 focusing on active ingredients with remineralizing, antibacterial, or plaque-removing effects, and to discuss their influence on caries prevention. For this, worldwide patent applications were searched using the international database Espacenet from the European Patent Office. Additionally, toothpaste products were searched using the Mintel product database from 1996 to 2023. The searched ingredients were (in alphabetical order): calcium carbonate, calcium phosphates, hydrated silica, sodium fluoride, sodium lauryl sulfate, triclosan, xylitol, and zinc salts as they are known from the scientific literature to be remineralizing or antibacterial/antiplaque agents. It was shown that the number of patent applications containing these ingredients significantly increased since the 1970s. As these ingredients have remineralizing, antibacterial, or plaque-removing effects, they all can contribute to caries prevention. In conclusion, and within the limitations of this approach, this study shows that toothpaste formulations have greatly improved over the past decades by using various active anticaries ingredients.

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“…Triclosan has antibacterial properties, including activity against Streptococcus mutans [ 9 , 28 ]. However, in recent years, there has been controversy about its safety [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Prevention of Dental Caries: A Review on the Improvements of Toothpaste Formulations from 1900 to 2023

Unterbrink,

Schulze zur Wiesche,

Meyer

et al. 2024

Dentistry Journal

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“…Over the last few years, many chemical substances have been reported to have efects on bacterial cell adhesion. Some, such as chlorhexidine [25], delmopinol [26], and triclosan [27,28] have shown potent inhibitory efects on bioflm development and maturation. Nevertheless, they exhibit several side efects such as tooth and tongue staining, taste alteration, and increased supragingival calculus formation [29].…”

Section: Introductionmentioning

confidence: 99%

Potential Effect of Giant Freshwater Prawn Shell Nano Chitosan in Inhibiting the Development of Streptococcus mutans and Streptococcus sanguinis Biofilm In Vitro

Haniastuti

Puspasari

Hakim

et al. 2023

International Journal of Dentistry

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An oral biofilm comprises a variety of bacteria including Streptococcus mutans and Streptococcus sanguinis that cause human infections, such as caries and periodontitis. Thus, biofilm management plays an important part in the prevention and treatment of oral diseases. Nano chitosan is a bioactive material that has antimicrobial activities. This in vitro study aimed to evaluate the effect of nano chitosan synthesized from giant freshwater prawn shells (PSNC) on S. mutans and S. sanguinis biofilm development. PSNC was prepared from the extracted chitosan of giant freshwater prawn (Macrobrachium rosenbergii) shells using the ionic gelation method. The effect of PSNC on S. mutans ATCC 25175 and S. sanguinis ATCC10556 biofilm formation was evaluated using the crystal violet assay. Both bacteria were inoculated in the presence of various concentrations (5, 2.5, and 1.25 mg/ml) of PSNC for 24 h and 48 h. Confocal laser scanning microscopy (CLSM) and scanning electron microscopy were performed to visualize and study the biofilm architectural features. The biofilms were stained with the BacLight Bacterial Viability Kit prior to CLSM observation to monitor the viability of the biofilm. The results showed that PSNC exposure for 24 h and 48 h inhibited the formation of S. mutans and S. sanguinis biofilms. The biofilm formation inhibition percentage increased with an increase in the PSNC concentration ( p < 0.05 ). The highest inhibitory activity was shown at 5 mg/ml PSNC ( p < 0.05 ). Those findings were confirmed by the subsequent findings using the CLSM and SEM analyses. The biofilm architecture was strongly disrupted upon treatment with PSNC. After exposure to 5 mg/ml PSNC, the number of bacteria significantly decreased. The remaining bacteria were seen as individual cells, showing damaged cells. In conclusion, PSNC inhibits the development of S. mutans and S. sanguinis biofilm in vitro, indicating the potential of PSNC in clinical application for oral bacterial infection, prevention, and treatment.

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Triclosan antimicrobial activity against dental-caries-related bacteria

Cited by 2 publications

References 22 publications

Prevention of Dental Caries: A Review on the Improvements of Toothpaste Formulations from 1900 to 2023

Prevention of Dental Caries: A Review on the Improvements of Toothpaste Formulations from 1900 to 2023

Potential Effect of Giant Freshwater Prawn Shell Nano Chitosan in Inhibiting the Development of Streptococcus mutans and Streptococcus sanguinis Biofilm In Vitro

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