Bioavailability augmentation of silymarin using natural bioenhancers: An in vivo pharmacokinetic study

Abstract

Pharmacokinetic studies were carried out in male and female rats to quantify silymarin as silybin (A+B) after the oral administration of various silymarin formulations combined with three bioenhancers, namely, lysergol, piperine, and fulvic acid, and compared with plain silymarin formulation (control). A non-compartmental analysis, model independent analysis, was utilized, and various pharmacokinetic parameters (C max , T max , and AUC 0-t ) were calculated individually for each treatment group, and the values were expressed as mean ± SEM (n = 6). Plasma samples obtained from the rats were analyzed for the concentration of silymarin through a validated RP-HPLC method and on the basis of data generated from the pharmacokinetic studies. Results indicated that the bioenhancers augmented pharmacokinetic parameters and bioavailability increased 2.4-14.5-fold in all the formulations compared with the control. The current work envisages the development of an industrially viable product that can be further subjected to clinical trials and scientifically supports the development of silymarin as a contemporary therapeutic agent with enhanced bioavailability and medicinal values.

Phyto-pharmacological review on bioavailability enhancer [Trikatu]

“…Bio-enhancers, which come from traditional Indian medicine, offer a unique technique that could potentially lower drug prices, reduce toxicity, and decrease adverse consequences. Ongoing research on expensive, poisonous, or poorly bioavailable medications emphasizes the significance of finding an optimal bioenhancer-one that is safe, effective, cost-effective, easily accessible, and nonaddictive [5] . In Ayurvedic medicine, incorporating bio-enhancers can potentially reduce treatment costs by enhancing drug bioavailability.…”

Use of Silybum marianum Extract and Bio-Ferment for Biodegradable Cosmetic Formulations to Enhance Antioxidant Potential and Effect of the Type of Vehicle on the Percutaneous Absorption and Skin Retention of Silybin and Taxifolin

“…Silybin can be used to create products that shield the skin from UV rays, such as cosmetic creams, and is of significant interest in the cosmetics industry, particularly for anti-aging and anti-free radical products. In the presence of phospholipids, silybin can undergo transformations, forming complexes better able to traverse the biomembrane [17][18][19][20][21][22].…”