Naringin is a promising natural compound for therapy of iron-overload disorders

Abstract

Naringin has been shown to exhibit satisfying iron chelation capacity. Considering the side effects of routinely-used iron chelator (desferrioxamine, DFO), we decided to evaluate the iron chelation potency of naringin to discover whether or not it can be a promising natural substitute for treatment of excessive iron-related diseases. is being used Therefore, we provided 35 mice were classified into and they were divided into 5 five groups of 7 and subjected to iron dextran administration to induce the iron-overload condition. Iron-overloaded mice were then threated with normal saline (as control), naringin or DFO (n=7). Group A treated by normal saline, the others treated with iron dextran. After that group A and B treated with normal slaine, group C received desferal, group D and E received high and low dose of naringin respectively. Morphology changes, and iron deposition in liver tissues were studied using H&E and Perl's staining.after The results revealed that naringin is more potent thant DFO in removing excessive iron ions deposited in liver tissues, indicating indication that naringin is a promising natural compound for therapy of iron overload disorders.

The natural iron chelators' ferulic acid and caffeic acid rescue mice's brains from side effects of iron overload

“…Due to the negative effects of DFO, the use of natural compounds as iron chelators is justified. Other studies have shown some natural products, such as CaA, FA, Berberine, and Vanillic acid, reduced iron content in the heart or liver significantly (2,(40)(41)(42). Resveratrol reduces oxidative stress in the brains of treated rats (43).…”