Chemical composition, antiproliferative and antioxidant attributes of ethanolic extract of resinous sediment from Etlingera elatior (Jack.) inflorescence

Abstract

The ethanolic extract of resinous sediment (EERS) of Etlingera elatior young inflorescence was examined for its anticancer effect and potential antioxidant activity. The anticancer effect of the EERS was evaluated on four human cancer cell lines, HCT 116, HT-29, Hela, and MCF-7, using the MTT assay. GC-MS analysis showed that the main components found in the EERS were nonyl cyclopropane (4.44%), 1-tetradecane (3.66%), cyclotetradecane (2.41%), cyclododecane (1.92%), and 1-decene (1.72%). The antioxidant activity was determined through different methods. High amounts of TPC and TFC in the EERS were found. Moderate antioxidant capacity of the EERS was detected by DPPH and ABTS assays, with EC 50 values of 44.19 and 56.61 μg/mL and a high FRAP value of 281.79 nmol Fe +2 equivalent/mg extract. In the MTT assay, the EERS showed potent anticancer activity, with IC 50 values of 19.82, 37.001, 50.49, and 53.29 μg/mL against HT-29, HCT 116, Hela, and MCF-7 tumour cell lines, respectively. Moreover, the results were comparable to or less potent than the standard reference drug, 5-fluorouracil. The results showed that the EERS of Etlingera elatior inflorescence contained a high amount of polyphenols and flavonoids, which may to the selective antiproliferative effects towards colon cancer in vitro.

In vitro antioxidant properties and antimicrobial activity of the ethanolic extract of Senecio nutans Sch. Beep. (Asteraceae)

“…In a previous study carried out by Parra et al (2018) demonstrated the antioxidant capacity of the aerial parts the ethanolic extract of S. nutans (ABT 0.01301 mM TE/g and FRAP 0.02765 mM TE/g). This indicates that its polyphenolic components are reducing agents (electron donors) or metal chelators (Al-Mansoub et al, 2021), with the ability to eliminate hydroxyl radicals, superoxide anion, and others (Zhang et al, 2019). There is a significant relationship between antioxidant activity and total polyphenol content, specifically between TPC/DPPH and TPC/ABTS, as there is a 96.57% and 79.53% linear relationship, respectively.…”

Medicinal potential and health benefits of torch ginger (Etlingera elatior)

“…This finding shows that torch ginger extract could be used as a skin cancer chemopreventive or chemotherapeutic drug. Moreover, the anticancer activity of the torch ginger inflorescence was examined by Al-Mansoub et al (2021) in four human cancer cell lines: HCT 116, HT-29, Hela, and MCF-7. The human colorectal adenocarcinoma cell line HT-29 was susceptible to the extraction potential selective cytotoxicity.…”

Chemical composition, in vitro assessment of antioxidant properties and cytotoxicity activity of ethanolic and aqueous extracts of Ajuga orientalis L. (Lamiaceae)

“…The plants containing abundant phenols and flavonoid compounds are a probable source of natural antioxidants. The ability of phenolic compounds to act as reducing agents, electron donors, oxygen quenchers, or metal chelators is mainly attributable to their redox characteristics (Al-Mansoub et al, 2021). The antioxidant activity of A. ciliata Bunge (PAB) was reported by Zhang et al (2019).…”