Protective effects of Urtica dioica L. seed extract on liver tissue injury and antioxidant capacity in irradiated rats

Yıldızhan, Kenan; Demirtas, Omer Can; Uyar, Ahmet; Huyut, Zübeyir; Çakır, Tahir; Keleş, Ömer Faruk; Yener, Zabit

doi:10.1590/s2175-97902019000318354

Cited by 7 publications

(3 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unfortunately, it leads to DNA damage and the creation of free radicals, including oxygen, hydroxyl, and superoxide radicals, through the breakdown of water molecules in the cell [21,22]. Such reactive oxygen species are known to induce carcinogenesis and mutagenesis [23].…”

Section: Discussionmentioning

confidence: 99%

Radioprotective effects of quercetin and curcumin on hepatotoxicity and nephrotoxicity in male Albino rats

Ali

Yassen

Azzoz

et al. 2023

Preprint

View full text Add to dashboard Cite

The present study aimed to assess the radioprotective effects of curcumin in combination with quercetin against radiation-induced changes in some histopathological, immunohistochemical, and biophysical parameters. The current study rats had been grouped into control, curcumin, quercetin, gamma irradiated (8 Gy fractionated dose), curcumin pretreated irradiated, quercetin pretreated irradiated, and both curcumin and quercetin pretreated irradiated groups. Gamma radiation exposure resulted in hepatic and renal damage. Administration of curcumin along with quercetin before gamma radiation exposure reduced the liver and kidney damage caused by radiation, demonstrating the radioprotective effects of both curcumin and quercetin antioxidants through free radicals scavenging effects, P53, and TNF-α inhibition, and structural changes measured by Fourier Transform Infrared (FTIR). The cellular damage by gamma radiation is greatly mitigated by administration of curcumin and quercetin before radiation exposure.

show abstract

Section: Discussionmentioning

confidence: 99%

Radioprotective effects of quercetin and curcumin on hepatotoxicity and nephrotoxicity in male Albino rats

Ali

Yassen

Azzoz

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…These results are in line with the previous studies stating that SN had hepato‐protective property (Uyar et al., 2016 ). SN inhibits liver damage with its potent antioxidant activity (Yildizhan et al., 2020 ). In the current experiment, the effects of SN on alleviating the hepatic damage were revealed with the decreases in the serum level of ALT and CK in the broilers.…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary stinging nettle (Urtica dioica) on hormone stress and selected serum biochemical parameters of broilers subjected to chronic heat stress

Farahani

Hosseinian

2022

Veterinary Medicine & Sci

View full text Add to dashboard Cite

Background: Heat stress is one of the most critical problems confronting the poultry industry. Stinging nettle (SN) is a medicinal plant with potent antioxidant properties. Objective:The goal of this study was to evaluate the effects of dietary SN at two different levels (2 and 4%) on the serum levels of cortisol and some selected parameters of broilers exposed to chronic heat stress.Methods: A total of 240 broiler chickens were randomly assigned to six dietary groups as follows: (1) control: fed the basal diet; (2) HS: heat-stressed broiler fed the basal diet; (3) HS-SN2: heat-stressed broiler fed 2% dietary SN; (4) HS-SN4: heat-stressed broilers fed 4% SN; (5) SN2: no heat-stressed broilers fed the basal diet supplemented with 2% SN; (6) SN4: no heat-stressed broilers fed the basal diet supplemented with 4% SN. Diet supplementation with SN was performed from days 14 to 35 and chronic heat stress was induced from days 22 to 29. The serum parameters were evaluated on days 14, 21, 29 and 35.Results: HS had higher serum levels of cortisol, total cholesterol (TC), aspartate aminotransferase, alanine aminotransferase and creatine kinase (CK) compared to the other treatments. HS-SN4 had significantly lower cortisol, TC, alanine aminotransferase and CK compared to HS and HS-SN2. Conclusions:The inclusion of 4% SN powder in the broilers' diet alleviated the negative effects of heat stress by decreasing cortisol, TC and tissue damage indices. It seems that dietary SN could be used as a feed additive in the poultry diet for improving the health status and defence mechanisms of the birds under stressful conditions.

show abstract

“…The GSH-Px activity was found to be higher in the liver compared to the irradiated group. More studies with more animals are suggested to achieve significant results for other antioxidant enzymes [ 105 ].…”

Section: Antioxidant Potential Of Udmentioning

confidence: 99%

Antioxidant Activity of Urtica dioica: An Important Property Contributing to Multiple Biological Activities

Jaiswal

Lee

2022

Antioxidants

View full text Add to dashboard Cite

Urtica dioica (UD) is a multi-functional plant known to be used as both food and medicine from ancient times. The plant has the potential to be used as a fertilizer and for biological pest control. It is also used in textile and related industries for its quality fibers. In the recent past, the plant has received great attention for its numerous important biological activities and food applications. The antioxidant activity of UD is the crucial factor supporting its important biological activities, such as anticancer, antidiabetic and anti-inflammatory properties. The antioxidant activity of UD is also found to be protective in different organs, including the brain, liver, lungs, kidney, ovary, and uterus, and may also be protective against diseases associated with these organs. Few clinical studies have endorsed the antioxidant potential of UD in patients. The current work is an attempt to comprehensively compile and discuss the antioxidant activity of UD from in vitro, in vivo and human studies. The insights of the current study would be helpful in getting a panoramic view of the antioxidant potential of UD, and provide direction for optimizing and developing it for therapeutic applications against important diseases and conditions in the near future.

show abstract

Protective effects of Urtica dioica L. seed extract on liver tissue injury and antioxidant capacity in irradiated rats

Cited by 7 publications

References 32 publications

Radioprotective effects of quercetin and curcumin on hepatotoxicity and nephrotoxicity in male Albino rats

Radioprotective effects of quercetin and curcumin on hepatotoxicity and nephrotoxicity in male Albino rats

Effects of dietary stinging nettle (Urtica dioica) on hormone stress and selected serum biochemical parameters of broilers subjected to chronic heat stress

Antioxidant Activity of Urtica dioica: An Important Property Contributing to Multiple Biological Activities

Contact Info

Product

Resources

About