Microwave-assisted synthesis and pharmacological screening of some triazolothiadiazole derivatives

Gorgu, Ozge; Yıldırım, Engin; Özkan, Yeşim; Çakır, Burçin; Erol, Kevser; Önkol, Tijen

doi:10.1590/s2175-97902019000318111

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…anticonvulsant [6], antidepressant [7], antiviral [8], anti-inflammatory [9], antinociceptive [10], antidiabetic and antioxidant [11], anticancer [12] agents. In addition, the structure of 1,2,4-triazole is resistant to metabolic transformations and is able to participate in the formation of intermolecular chemical bonds [13].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Properties and Biological Potential Some Condensed Derivatives 1,2,4-Triazole

Gotsulya

Brytanova

2022

Ankara Universitesi Eczacilik Fakultesi Dergisi

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Objective:The aim of the work was to develop effective methods for the synthesis of biologically active heterocyclic systems containing pyrrole, indole and 1,2,4-triazole. In this study, firstly fourteen [1,2,4]triazolo [3,4-b][1,3,4]thiadiazoles compounds requiring for this study were synthesized.Material and Method: Chemical structures of synthesized compounds were characterized with elemental analysis, 1 H NMR, LC-MS techniques. The biological potential of the synthesized substances was estimated by the molecular docking method.Result and Discussion: An optimal method for the synthesis of [1,2,4]triazolo [3,4-b][1,3,4]thiadiazoles has been developed. In molecular modeling studies, the compounds were found to be similar to known drugs in some respects. Besides, the interaction of each molecule in the active site of the crystal structures of cyclooxygenase-1, lanosterol 14-α-demethylase, kinases of anaplastic lymphoma were considered as in silico.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Properties and Biological Potential Some Condensed Derivatives 1,2,4-Triazole

Gotsulya

Brytanova

2022

Ankara Universitesi Eczacilik Fakultesi Dergisi

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SYNTHESIS AND PROPERTIES OF A SERIES OF 3-ALKYLTHIO DERIVATIVES 9-METHYLPYRAZOLO[1,5-d][1,2,4]TRIAZOLO[3,4-f][1,2,4]TRIAZINE

Fedotov

Gotsulya

ZAİKA

et al. 2023

Ankara Ecz. Fak. Derg.

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Objective: The aim of the work was to develop effective methods for the synthesis of promising condensed heterocyclic systems based on pyrazole and 1,2,4-triazole. In the process of realizing the set goal, a number of new pyrazolo[1,5-d][1,2,4]triazolo[3,4-f][1,2,4]triazines were synthesized. Material and Method: Chemical structures of synthesized compounds were characterized with elemental analysis, 1H-NMR, LC-MS techniques. The biological potential of the synthesized substances was estimated by the molecular docking method. Result and Discussion: An optimal method for the synthesis of pyrazolo[1,5-d][1,2,4]triazolo[3,4-f][1,2,4]triazines has been developed. In molecular modeling studies, the compounds were found to be similar to known drugs in some respects. The interaction of each molecule with the crystal structures of cyclooxygenase-2, lanosterol-14α-demethylase, kinases of anaplastic lymphoma in the active site were considered as in silico.

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Microwave-assisted synthesis and pharmacological screening of some triazolothiadiazole derivatives

Cited by 2 publications

References 30 publications

Synthesis, Properties and Biological Potential Some Condensed Derivatives 1,2,4-Triazole

Synthesis, Properties and Biological Potential Some Condensed Derivatives 1,2,4-Triazole

SYNTHESIS AND PROPERTIES OF A SERIES OF 3-ALKYLTHIO DERIVATIVES 9-METHYLPYRAZOLO[1,5-d][1,2,4]TRIAZOLO[3,4-f][1,2,4]TRIAZINE

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