Antihypoxic activities of Crataegus pentaegyn and Crataegus microphylla fruits-an in vivo assay

Ebrahimzadeh, Mohammad Ali; Khalili, Masoumeh; Jafari, Narjes; Zareh, Giti; Farzin, Davood; Amin, Gholamreza

doi:10.1590/s2175-97902018000217363

Cited by 10 publications

(6 citation statements)

References 17 publications

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“…The effects of polyphenolic extracts of C. pentagyna and C. microphylla fruits on hypoxia, which is a state of oxygen deficiency occurring in heart diseases, ischemia, bleeding and heart attack, were studied using male Swiss albino mice model. It was found that the extracts exhibited significant anti-hypoxic activity and prolonged animal survival time (Ebrahimzadeh et al, 2018). The activity of these extracts was attributed to a high TPC, 1,136.0 and 721.1 GAE mg/g in C. pentagyna and C. microphylla, respectively.…”

Section: Cardioprotective Benefitsmentioning

confidence: 99%

Phytochemical composition and bioactivities of hawthorn (Crataegus spp.): review of recent research advances

Venskutonis¹

2018

JFB

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Hawthorn (Crataegus spp.) is one of the most famous plants which has been used as natural medicine and nutraceutical. Its phytochemical composition, bioactive compounds and health benefits have been intensively studied and hawthorn preparations may be recognized as classical natural products for cardiovascular health. Polyphenolic compounds of different hawthorn anatomical parts as well as their extracts have been the focus of a majority of these studies, although various other classes of natural health promoting constituents have also been isolated, identified and characterized. Regardless, numerous published reports have particularly focused on the activity mechanisms which are very important for supporting various health benefits. This review summarizes the most recent studies on hawthorn, mainly published since 2015. Search of different databases indicates that approximately 200 publications, which are relevant to phytochemistry and health benefits of Crataegus spp., have appeared since then, most of them have not been included in the existing reviews.

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Section: Cardioprotective Benefitsmentioning

confidence: 99%

Phytochemical composition and bioactivities of hawthorn (Crataegus spp.): review of recent research advances

Venskutonis¹

2018

JFB

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“…As indicated above, many beneficial properties have been attributed to hawthorn, including anticancer [55], anti-HIV, anti-diabetic [56], and anticoagulant activity [57], cardioprotective effects [58][59][60][61][62][63][64][65], hepatoprotective effects, antihyperglycemic and antihyperlipidemic activities, wound healing effects [66], antimicrobial effects, gastroprotective effects, treatment of metabolic syndrome [67], regulation of cholesterol homeostasis [68], anti-atherosclerosis effects [69][70][71][72], anti-aging effects [73], ischemia protective effects [74], treatment of cognitive disorders, neuroprotective effects, regulating gastrointestinal motility [75], anti-inflammatory activities [76,77], regulation of the gut-brain axis [78], treatment of hypertension [79], antioxidant activity [80][81][82][83][84][85], anti-hypoxic activities [86], antidepressant effects [87], anti-Alzheimer's effects, and treatment of intestinal microbial disorder [88].…”

Section: In Vitro and In Vivo Therapeutic Potentials Of Hawthorn: An mentioning

confidence: 99%

Hawthorn (Crataegus spp.): An Updated Overview on Its Beneficial Properties

Nazhand

Lucarini²,

Durazzo³

et al. 2020

Forests

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Medicinal plants, many of which are wild, have recently been under the spotlight worldwide due to growing requests for natural and sustainable eco-compatible remedies for pathological conditions with beneficial health effects that are able to support/supplement a daily diet or to support and/or replace conventional pharmacological therapy. The main requests for these products are: safety, minimum adverse unwanted effects, better efficacy, greater bioavailability, and lower cost when compared with synthetic medications available on the market. One of these popular herbs is hawthorn (Crataegus spp.), belonging to the Rosaceae family, with about 280 species present in Europe, North Africa, West Asia, and North America. Various parts of this herb, including the berries, flowers, and leaves, are rich in nutrients and beneficial bioactive compounds. Its chemical composition has been reported to have many health benefits, including medicinal and nutraceutical properties. Accordingly, the present review gives a snapshot of the in vitro and in vivo therapeutic potential of this herb on human health.

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“…Negative control groups were treated with normal saline and propranolol used as the positive control 6 .…”

Section: Hypoxia Modelsmentioning

confidence: 99%

Protective Effects of Edaravone Against Hypoxia-Induced Lethality in Male Swiss Albino Mice

Shaki

Mokhtaran

Shamshirian

et al. 2020

Preprint

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Edaravone is used for the treatment of acute cerebral infarction in Japan. However, nothing is known about the protective effects of this drug against hypoxia-induced lethality. In this study, the protective effects of edaravone against hypoxia-induced lethality and oxidative stress in mice were evaluated by three experimental models of hypoxia, which are asphyctic, haemic, and circulatory. Statistically significant protective activities were established in all tested models of hypoxia. Antihypoxic activities were especially pronounced in asphytic and circulatory hypoxia. The effect was dose-dependent. Edaravone, at 5 mg kg -1 , showed statistically significant activities respect to the control groups. It significantly prolonged the latency for death. At 2.5 mg kg -1 , it also prolonged survival time (26.08 ± 5.26 min), but this effect was not statistically significant from the control (P>0.05). On the other hand, edaravone significantly inhibited hypoxia-induced oxidative stress (lipid peroxidation and glutathione oxidation) in three models of hypoxia. In conclusion, the results obtained in this study showed that Edaravone has very good protective effects against the hypoxia in all tested models.

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Antihypoxic activities of Crataegus pentaegyn and Crataegus microphylla fruits-an in vivo assay

Cited by 10 publications

References 17 publications

Phytochemical composition and bioactivities of hawthorn (Crataegus spp.): review of recent research advances

Phytochemical composition and bioactivities of hawthorn (Crataegus spp.): review of recent research advances

Hawthorn (Crataegus spp.): An Updated Overview on Its Beneficial Properties

Protective Effects of Edaravone Against Hypoxia-Induced Lethality in Male Swiss Albino Mice

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