Anti-inflammatory and healing action of oral gel containing borneol monoterpene in chemotherapy-induced mucositis in rats ( Rattus norvegicus )

Júnior, Braz José do Nascimento; Brito, Lucas de Souza; Barros, Walquíria Nunes; Gonçalves, Daniela Marques; Matos, Luana de Souza; Nascimento, Cínthia Reyjane Borges; Ribeiro, Luciano Augusto de Araújo; Lima, Ricardo Santana de; Silva-Júnior, René Geraldo Cordeiro; Reis, Sílvio Alan Gonçalves Bomfim; Gonçalves, Talita Mota; Amorim, Elba Lúcia Cavalcanti de

doi:10.1590/s2175-97902017000300081

Cited by 6 publications

(2 citation statements)

References 23 publications

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“…Natural health products (NHP) have also been studied mainly because of their antioxidant, antiinflammatory and healing effects as well as anticancer activity [64,[75][76][77][78]. In this regard, Buccal Bullfrog (Rana catesbeiana Shaw) oil emulsion was successfully used as a mucoadhesive system to treat oral candidiasis [79].…”

Section: Medicinal Herb Derivativesmentioning

confidence: 99%

Emerging approaches of wound healing in experimental models of high-grade oral mucositis induced by anticancer therapy

et al. 2021

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Clinical guidelines for oral mucositis (OM) still consist in palliative care. Herein, we summarize cellular and molecular mechanisms of OM ulceration in response to chemical therapies in animal models. We discuss evidenced anti-inflammatory and anti-oxidant drugs which have not been ever used for OM, such as synthetic peptides as well as cell therapy with mesenchymal stem cells; amniotic membranes, mucoadhesive polymers loaded with anti-inflammatory agents and natural or synthetic electrospun. These approaches have been promising to allow the production of drugloaded membranes, scaffolds for cells encapsulation or guided tissue regeneration.

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Section: Medicinal Herb Derivativesmentioning

confidence: 99%

Emerging approaches of wound healing in experimental models of high-grade oral mucositis induced by anticancer therapy

et al. 2021

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“…Although the mechanism of action is not well established, it is hypothesized that the gel inhibits cyclooxygenase because it has anti-inflammatory properties. The Extract of Hypericum perforatum L. contains in its phytocomplex the borneol and have shown anti-inflammatory and cicatricial activities in OM in animal models [5,6]. Borneol has an…”

Section: Introductionmentioning

confidence: 99%

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2018

GJPPS

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Oral mucositis (OM) is a complication of cancer therapy. Because of the associated complications, patients with OM go through decreasing doses or until the suspension of chemotherapy treatment or radiotherapy of head and neck until the improvement of the clinical picture, with that, exposing them the progression of the tumor. Current treatments produce limited results and rely on oral cryotherapy using ice, low-power laser exposure and systemic administration of keratinocyte growth factor (Palifermin).The use of medicinal plants and herbal medicine in the treatment of OM is still little used, but with a tendency to expand and accept the pharmaceutical market. We can conclude that phytotherapy is an expanding market and that, although efficient, needs more research and better acceptance of oncologists and other health professionals. Also some mechanisms of action are still not well understood, therefore, studies are needed that evaluate the long-term effects, in addition to standardized clinical protocols that prove efficacy. An efficient natural product in the treatment of OM should have an anti-inflammatory, bactericidal, antioxidant and healing effect on oral mucosa. In this sense, the search for multi-herbs products can be promising, since the plants together can have superior synergistic effects to the isolated species. However, there are few products in the current market with this profile.

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The effect of hydroalcoholic extract of Psidium guajava L. on experimentally induced oral mucosal wound in rat

Ghaderi

Ebrahimi

Aslani

et al. 2022

BMC Complement Med Ther

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Background The aim of this study was to evaluate the biological effects of hydroalcoholic extract of Psidium guajava L leaves and phenytoin as a standard agent on the induced oral mucosal wound. Methods Hundred seventy Sprague Dawley rats were grouped in 5 clusters randomly. Oral mucosal wounds were induced in all rats except for the control group. Phenytoin and guajava leaf extract were used as a mouthwash. Twelve rats from the 5 groups were euthanized on day 7th and 10th, and 10 rats from each group were sacrificed on the 14th day. Interleukin-6 and total antioxidant capacity were determined in the serum. The tissues were evaluated for pathological and stereological assessments. Phytochemical analyses were performed on the hydroalcoholic extract of Psidium guajava L to determine the antioxidant potency. Results Total phenolic content test and DPPH analysis demonstrated the high potential of antioxidant capacity of Psidium guajava L. Decreasing IL-6 and increasing TAC were seen in the guajava hydroalcoholic extract and phenytoin groups. The difference of IL-6 between the wound treated guajava group and the wounded group was significant. The wound treated guajava group and wound treated phenytoin group on the 14th day increased the number of fibroblast cells and volume density of sub-mucosae effectively to the same thickness to be considered as a healed sub-mucosae layer. The volume density of the epithelium changes showed statistically significant different responses based on gender. Conclusion In conclusion, hydroalcoholic extract of Psidium guajava L leaves might exert theraputic effects on oral mucositis.

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Anti-inflammatory and healing action of oral gel containing borneol monoterpene in chemotherapy-induced mucositis in rats ( Rattus norvegicus )

Cited by 6 publications

References 23 publications

Emerging approaches of wound healing in experimental models of high-grade oral mucositis induced by anticancer therapy

Emerging approaches of wound healing in experimental models of high-grade oral mucositis induced by anticancer therapy

Untitled

The effect of hydroalcoholic extract of Psidium guajava L. on experimentally induced oral mucosal wound in rat

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