Current and Potential Applications of Monoterpenes and Their Derivatives in Oral Health Care

Abstract

Plant products have been employed in medicine for centuries. As the world becomes more health-conscious, there is a growing interest in natural and minimally processed products for oral health care. This has led to an increase in research into the bioactive compounds found in plant products, particularly monoterpenes. Monoterpenes are known to have beneficial biological properties, but the specific mechanisms by which they exert their effects are not yet fully understood. Despite this, some monoterpenes are already being used in oral health care. For example, thymol, which has antibacterial properties, is an ingredient in varnish used for caries prevention. In addition to this, monoterpenes have also demonstrated antifungal, antiviral, and anti-inflammatory properties, making them versatile for various applications. As research continues, there is potential for even more discoveries regarding the benefits of monoterpenes in oral health care. This narrative literature review gives an overview of the biological properties and current and potential applications of selected monoterpenes and their derivatives in oral health care. These compounds demonstrate promising potential for future medical development, and their applications in future research are expected to expand.

Natural Bioactive Compounds in the Management of Periodontal Diseases: A Comprehensive Review

“…Thymol can bind to upstream kinases in the MAPK pathway, such as MEK1/2 and ERK1/2, preventing their phosphorylation and subsequent activation through hydrophobic interactions and hydrogen bonding with key residues in the kinase active sites [58]. Terpenoids, such as eugenol and thymol, exert their therapeutic effects in periodontal therapy through precise molecular interactions [59]. Their ability to disrupt microbial cell membranes, inhibit key enzymes, and interfere with quorumsensing mechanisms provides potent antimicrobial activity.…”

Plant Monoterpenes and Essential Oils as Potential Anti-Ageing Agents: Insights from Preclinical Data

“…Bearing this in mind, we sought to review the potential of volatile monoterpenes, a group of compounds highly prevalent in aromatic plants. These compounds are valued by several industries due to their bioactive potential, namely antimicrobial, antioxidant, anti-inflammatory, analgesic, antinociceptive and anticancer effects, as reviewed elsewhere [13]. Importantly, many monoterpenes are considered safe for consumer use and have a generally recognized as safe (GRAS) status by the Food and Drug Administration (FDA), being included in many foods and beverages.…”