Changes in weight and body fat after use of tetracycline and Lactobacillus gasseri in rats

Marciano, Jorge José; Fiol, Fernando de Sá Del; Ferreira, Alessandra Cristina Marciano Tardelli; Marques, Maria Claudia; Santana, Luciane Lopes

doi:10.1590/s2175-97902017000116059

Cited by 10 publications

(3 citation statements)

References 47 publications

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“…The antibiotic serves only to alter it (Backhed et al, 2004; Turnbaugh et al, 2006; Goodman et al, 2011; Kimura et al, 2013; Cox et al, 2014; Gerard, 2016). Studies carried out using regular animals (non-germ-free) that received antibiotics point to the same direction, increasing the weight of the animals due to changes in their gut microbiota (Cho et al, 2012; de Sa Del Fiol et al, 2014; Khan et al, 2016; Marciano et al, 2017).…”

Section: Antibiotics and Obesitymentioning

confidence: 98%

Obesity: A New Adverse Effect of Antibiotics?

et al. 2018

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Since the introduction of antibiotics, they have been used freely, with their prescription occurring almost always when they were not necessary. The other major form of contact between humans and antibiotics, now unintentionally, is with the large amount of these drugs in the environment and in our food. The relationship between antibiotic use and the development of obesity has become increasingly evident and apparent in humans, with some authors clearly establishing the relationship between the large-scale use of antibiotics in the past 70 years and the “epidemic” of obesity that has occurred in parallel, almost as an adverse epidemiological effect. In the research effort entertained herein, a correlation between the use and abuse of antibiotics and the onset of obesity was investigated.

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Section: Antibiotics and Obesitymentioning

confidence: 98%

Obesity: A New Adverse Effect of Antibiotics?

et al. 2018

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“…The gut microbiota composition indirectly influences the host's metabolic activity. This idea has been well supported by several studies involving mice models [62][63][64][65][66][67][68] . Another possible explanation within this context is that antibiotics caused a reduction in the bacteria population residing in the gastrointestinal tract.…”

Section: Mechanisms Of Agpsmentioning

confidence: 82%

Probiotics: Comprehensive Exploration of the Growth Promotion Mechanisms in Shrimps

Goh¹,

Tan²,

Law³

et al. 2023

Prog Micobes Mol Biol

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As feed accounts for a significant proportion of a farm’s expenditure, animal nutrition is one of the key profit determinants. Attributed to the size-dependent market value, enhancing shrimps' growth is essential to maximize profit. Despite not being the best option, antibiotics are often used as growth-promoting agents in farming. Although this trend is less explicit in aquaculture, increasing production yield is paramount, especially when intensive aquafarming compromises animal growth and increases disease prevalence. However, the environmental and clinical pitfalls of indiscriminate antibiotic usage are surfacing. Fortunately, increasing evidence demonstrated probiotics as a safer, more sustainable, and environmental-friendly substitute for antibiotics. Nonetheless, most studies are observational, and the growth-promotion mechanisms of these agents are yet to be elucidated. In this light, this review aims to decipher the growth promotion mechanisms of probiotics in shrimps based on the primary works conducted. Evidently, probiotic treatment modulates the gut microbiome composition. The growth promotion effect of probiotics is partly mediated through the production of bioactive compounds such as short-chain fatty acids, vitamins, and polyamines. Besides, elevated digestive enzyme activities following the introduction of probiotics may help enhance digestibility and utilization. Histological changes at the hepatopancreas and intestine were evident. Furthermore, probiotics may reinforce the protective mechanisms in the gut and strengthen immune function. Treated shrimps demonstrate better appetite and exhibit superior metabolic and growth-related genes profile. Contrasting these recognized mechanisms with antibiotics helps construct the initial framework for designing high-quality probiotics for growth enhancement in farmed animals.

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“…18 L. gasseri ATCC 33323 exhibited protective effects against tetracyclineinduced body fat accumulation in a rat animal model. 19 All evidence emphasized the efficiency of L. gasseri on the subject of obesity. Because the effect of probiotics in weight loss is species-and strain-specific and L. gasseri L66-5 promotes weight gain, 20 the efficiency of the L. gasseri strain on weight loss was determined in detail.…”

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confidence: 99%

Lactobacillus gasseri as a Functional Food and Its Role in Obesity

Mahboubi¹

2019

Int J Med Rev

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Introduction Obesity is a chronic, relapsing, progressive disease. It is identified by abnormal and excessive fat accumulation which is defined as a body mass index (BMI) higher than 25 kg/m 2. 1 The health risks of obesity include a wide range of medical, surgical, gynecological, obstetric, social, and psychological conditions such as hypertension, cerebrovascular incidents, cancers, hyperlipidemia, coronary heart disease, diabetes mellitus, and degenerative arthritis. 2 Therefore, the costs imposed by obesity are considerable. Changes in lifestyle, exercise, diet therapy, drugs with anti-lipase inhibitory effects, or medicinal plants are some ways to overcome obesity, but one critical factor related to obesity and metabolic disorders is the gut microbiota. The gut microbiota is related to obesity, type 2 diabetes, cardiovascular diseases, and non-alcoholic fatty liver disease. 3 The high proportion of intestinal firmicutes and low percentage of Bacteroides are associated with adipose tissue inflammation and obesity. 4 Bacteroides have a lower number of enzyme genes for lipid and carbohydrate metabolism than firmicutes, and they reduce the energy uptake from diets. 5 Probiotics as live healthy microorganisms are a promising approach to altering gut microbiota. 6 Among probiotics, Lactobacillus gasseri is known as the weight loss probiotic. In this review article, the efficiency of L. gasseri in weight loss is discussed. Lactobacillus gasseri Lactobacillus gasseri is an autochthonous human intestinal bacterium which is acid resistant, bile tolerant, and distinguished from L. acidophilus by typical phenotype characteristics. The cell wall composition and electrophoretic mobility of L. gasseri L-LDH is different from that of L. acidophillus. 7 Cardiolipin as a membrane phospholipid of L. gasseri JCM1131 plays a pivotal role in the bile acid resistance of bacteria. 8 Inulin, poly-oligosaccharides, and a broad range of fructooligosaccharides are synthesized by L. gasseri. 9 Inulin is synthesized from sucrose using inulosucrase from L. gasseri DSM 20604. 10 Lactobacillus gasseri reduces the number of fecal mutagenic enzymes, adheres to intestinal tissue, and stimulates macrophages in the intestine. It is able to adhere to Caco-2 cells and exhibits antimicrobial activity. It reduced the fecal coliforms, serum total cholesterol, LDL-cholesterol, triglycerides, and bile acids in rats. The levels of acidic steroid increased in feces, but totally neutral steroids were not affected by L. gasseri in hypercholesterolemic rats. 11 Two different mechanisms are proposed for reducing serum cholesterol using probiotic bacteria. L. gasseri is able to enhance the excretion of acidic steroids in feces and suppress the reabsorption of bile acids into the enterohepatic circulation. It is also able to adhere to the surface of the intestine and deconjugate bile acids with weak absorption from the small intestine is associated with high feces excretion by dietary fiber. Deconjucated bile acids are toxic for the growth of coliform or patho...

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Changes in weight and body fat after use of tetracycline and Lactobacillus gasseri in rats

Cited by 10 publications

References 47 publications

Obesity: A New Adverse Effect of Antibiotics?

Obesity: A New Adverse Effect of Antibiotics?

Probiotics: Comprehensive Exploration of the Growth Promotion Mechanisms in Shrimps

Lactobacillus gasseri as a Functional Food and Its Role in Obesity

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