Investigation of the role of rosmarinic acid treatment in regulating inflammation, cell damage, and angiogenesis in rat ovarian torsion and detorsion models

Değer, Uğur; Çavuş, Yunus

doi:10.1590/s0102-865020200030000004

Cited by 12 publications

(14 citation statements)

References 35 publications

(37 reference statements)

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“…However, RA has known anti-inflammatory effects (19). On the other hand, this effect is usually expressed through the levels of anti-inflammatory molecules.…”

Section: )mentioning

confidence: 99%

Comparison of local rosmarinic acid and topical dexpanthenol applications on wound healing in a rat experimental wound model

et al. 2021

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We compared the effects of rosmarinic acid and dexpanthenol in a rat experimental wound model. Twenty-four Wistar albino rats weighing 200-250 g were randomly divided into 3 groups. After 2-cm full-thickness skin defects were created, the wounds were washed with sterile 0.9% NaCl solution. After washing, the control group was left untreated, the second group received 5% dexpanthenol cream, and the third group received 10% rosmarinic acid cream. Before excision, the skin was evaluated macroscopically by measuring the reduction in wound size; after excision, histological examination (epithelization, inflammation, fibrosis, granulation) was performed. Macroscopic comparison of the wound sizes showed that group 3 showed a statistically significant difference in wound size reduction compared to the other two groups. Histopathological examination showed that there was no statistically significant difference between the groups. We found that the rosmarinic acid group had greater wound size reduction than the other two groups. However, epithelialization was detected in fewer cases. We believe that rosmarinic acid can be used as a topical cream for wound healing, as it leads to significant reduction in wound size, resulting in fewer scars.

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“…However, RA has known anti-inflammatory effects (19). On the other hand, this effect is usually expressed through the levels of anti-inflammatory molecules.…”

Section: )mentioning

confidence: 99%

Comparison of local rosmarinic acid and topical dexpanthenol applications on wound healing in a rat experimental wound model

et al. 2021

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“…The most effective clinical approach is early conservation surgery or detorsion. However, this treatment is often proceeded by neutrophil infiltration, an increase in free oxygen radicals and cytokines [ 35 ]. The combination of neutrophilia and lymphopenia results in the increased NLR observed in AT.…”

Section: Discussionmentioning

confidence: 99%

Predictive Role of Neutrophil to Lymphocyte Ratio in Adnexal Torsion: A Systematic Review and Meta-Analysis

Khanzadeh

Tahernia²,

Hernandez

et al. 2022

Mediators of Inflammation

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Introduction. The goal of this systematic review and meta-analysis was to consolidate the available data on the role of the neutrophil to lymphocyte ratio (NLR) in predicting adnexal torsion (AT), to help guide clinical decision-making and outcomes. Methods. We used Web of Science, PubMed, and Scopus to conduct a systematic search for relevant publications published before June 26, 2022. We reported standardized mean difference (SMD) with a 95% confidence interval (CI). Because a significant level of heterogeneity was found, we used the random-effects model to calculate pooled effects. We used the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) too for quality assessment. Results. Overall, 15 articles were included in the analysis. A random-effects model revealed that patients with AT had elevated levels of NLR compared to those with other adnexal masses ( SMD = 1.06 , 95 % CI = 0.67 to 1.45, p < 0.001 ). So, NLR had diagnostic value. In the subgroup analysis according to ethnicity, we found that Caucasian patients with AT had elevated levels of NLR compared to patients who were operated due to adnexal mass and reported as having a benign ovarian cyst, without torsion ( SMD = 1.12 , 95 % CI = 0.71 to 1.54, p < 0.001 ). However, in the case of East Asian patients, there was no difference between cases and controls ( SMD = 0.86 , 95 % CI = − 0.21 to 1.94, p = 0.11 ). The pooled sensitivity of NLR was 0.79 ( 95 % CI = 0.72 – 0.85 ), and the pooled specificity was 0.84 (95% CI, 0.74–0.91). Conclusion. In conclusion, there has been an interest in the use of NLR as a diagnostic marker for AT.

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“…Therefore, the hindrance of NF-κB activation results in a decrease in VEGF mRNA expressions (Shibata et al, 2002). RA given either before or after tumor induction has an anti-angiogenesis effect by suppression of VEGF expression or protein levels (Değer and Çavuş, 2020).…”

Section: Discussionmentioning

confidence: 99%

Rosmarinic acid suppresses inflammation, angiogenesis, and improves paclitaxel induced apoptosis in a breast cancer model via NF3 κB-p53-caspase-3 pathways modulation

Mahmoud¹,

Okda²,

Omran³

et al. 2021

J Appl Biomed

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Rosmarinic acid is a natural polyphenolic compound that is found in different plant species and used for different medicinal purposes. This study aimed to investigate the chemo-preventive effect of rosmarinic acid and evaluate its antitumor efficacy alone or in combination with Paclitaxel in breast cancer mice model. Ehrlich induced mice mammary solid tumor model was used in the study. Mice were treated with oral rosmarinic acid and intraperitoneal Paclitaxel. Inflammation, angiogenesis, and apoptosis were checked. Enzyme linked immunosorbent assay (ELISA), quantitative real time PCR, and immunohistochemical methods were performed. Rosmarinic acid used prior to tumor induction suppressed NF-κB, TNF-α, vascular endothelial growth factor (VEGF) serum levels, and VEGF receptors. It also triggered apoptosis by restoring the levels of P53, Bcl-2, Bax, and caspase-3. Furthermore, in Ehrlich solid tumor mice, rosmarinic acid, and/or Paclitaxel significantly suppressed tumor growth with an increase in apoptotic markers P53 and Caspase-3 levels, and suppressed the Bcl2/Bax ratio.Rosmarinic acid exerted chemo-preventive and therapeutic potential alone or in combination with Paclitaxel. Moreover, rosmarinic acid targets numerous signaling pathways associated with breast cancer.

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Investigation of the role of rosmarinic acid treatment in regulating inflammation, cell damage, and angiogenesis in rat ovarian torsion and detorsion models

Cited by 12 publications

References 35 publications

Comparison of local rosmarinic acid and topical dexpanthenol applications on wound healing in a rat experimental wound model

Comparison of local rosmarinic acid and topical dexpanthenol applications on wound healing in a rat experimental wound model

Predictive Role of Neutrophil to Lymphocyte Ratio in Adnexal Torsion: A Systematic Review and Meta-Analysis

Rosmarinic acid suppresses inflammation, angiogenesis, and improves paclitaxel induced apoptosis in a breast cancer model via NF3 κB-p53-caspase-3 pathways modulation

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