Poly (Lactic Acid) membrane and Sedum dendroideum extract favors the repair of burns in rats

Binotto, Juliane Peliçari; Mendes, Larissa Giorgetti; Gaspi, Fernanda Oliveira de Gaspari; Esquisatto, Marcelo Augusto Marretto; Andrade, Thiago Antônio Moretti de; Mendonça, Fernanda Aparecida Sampaio; Santos, Gláucia Maria Tech dos

doi:10.1590/s0102-865020200030000002

Cited by 8 publications

(4 citation statements)

References 39 publications

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“…The effect of the extract applied in isolation was also evaluated, which showed an increase in collagen fibers at 28 % and in the number of fibroblasts at 10 %, however, in this group, there was no significant angiogenesis, compared to the control group. On the other hand, it was observed that the groups treated with the biopolymer, alone or in association, showed an intense inflammatory response concerning the control group, of which the authors correlate this effect to the biopolymer membrane itself [57] because it is already mentioned in the literature [58] …”

Section: Resultsmentioning

confidence: 96%

Traditional Plants Used in Southern Brazil as a Source to Wound Healing Therapies

Pereira

Cury

Nunes

et al. 2023

Chemistry & Biodiversity

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In southern Brazil, the biodiversity is great and the traditional use of medicinal plants for wound healing has been documented in ethnobotanical studies and pharmacological studies have assessed their wound properties and phytochemistry. Therefore, this study evaluated ethnobotanical surveys regarding medicinal plants used in southern Brazil for wound healing and studies about the healing properties of these plants published between 2000 and 2022. To retrieve articles related to the study, Web of Science, PubMed (NLM), Open Access Journals, Scielo, Lilacs, and Google Scholar, with keywords including medicinal plants, wound healing, and South of Brazil, have been used. As a result, 73 medicinal plants belonging to 39 families were found in ethnobotanical surveys as a traditional resource used for wound healing in southern Brazil, 15 of which were cited more than once. Besides, 14 of these 15 plants were also used as healing agents worldwide. The most cited plant with healing actions in southern Brazil was Symphytum officinale L. (comfrey). From 2000 to date, 44 articles scientifically demonstrated the wound‐healing effects of the southern Brazilian plants found in ethnobotanical surveys reviewed. The folk medicine of southern Brazil presents a variety of medicinal plants for wound‐healing purposes, and scientific data were found for some of those plants. However, the wound‐healing properties of many plants have yet to be investigated, and the current literature still needs more phytochemical information about the plants studied. Aside from this, the future focus should be on the standardization of herbal extracts, and further research is required to investigate the pharmacological mechanisms. Clinical research in this area remains in its infancy and warrants more robust further clinical studies.

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Section: Resultsmentioning

confidence: 96%

Traditional Plants Used in Southern Brazil as a Source to Wound Healing Therapies

Pereira

Cury

Nunes

et al. 2023

Chemistry & Biodiversity

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“…Collagen fiber deposition is favored by the proliferation of fibroblasts, decreased inflammatory infiltrates, and the appearance of new blood vessels. In a continuous process, the wound bed is gradually replaced by a scar fibrous matrix resulting from the orderly deposition of new collagen fibers 50 …”

Section: Discussionmentioning

confidence: 99%

Efficacy ofLobelia alsinoidesLam ethanolic extract on a third‐degree burn: An experimental study on rats

Thanapaul

Ranjan

Manikandan

et al. 2020

Dermatologic Therapy

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This is the first study to evaluate the topical application of Lobelia alsinoides Lam (LT) ethanolic extract on burns in rats. A deep third-degree burn wound was inflicted in adult male Wistar rats and the burns were dressed daily with a topical ointment formulation (Patent filed) comprising of Lobelia alsinoides Lam (5% and 10% w/w). The wound had noteworthy contraction and quicker eschar removal in 10% w/w LTtreated groups followed by 5% w/w treated groups on comparing with the commonly prescribed ointment (Silverex TM containing 1% w/w Silver sulfadiazine). Histopathological analysis showed that ointment containing 10% w/w LT ethanolic extract significantly increased fibroblast growth, which plays a major role in anatomic integrity, collagen synthesis, and accelerated the rate of the healing process. This study shows that the ethanolic extract of Lobelia alsinoides Lam, a previously pharmacologically unreported traditional medicinal plant, possesses wound contraction and eschar removal properties on burn wounds.

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“…114 PLA is an environmentally friendly, biodegradable, and easy-to-process polymeric biomaterial with good biocompatibility and mechanical properties. 115 With the deepening of research on PLA, the PLA nanofibrous membranes prepared via electrospinning have become widely used in the treatment of periodontitis. Reise et al 116 prepared PLA-loaded metronidazole (MNZ) nanofibers via electrospinning.…”

Section: Polylactic Acidmentioning

confidence: 99%

Electrospun Nanofibers for Periodontal Treatment: A Recent Progress

Zhao¹,

Chen²,

Feng³

et al. 2022

IJN

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Periodontitis is a major threat to oral health, prompting scientists to continuously study new treatment techniques. The nanofibrous membrane prepared via electrospinning has a large specific surface area and high porosity. On the one hand, electrospun nanofibers can improve the absorption capacity of proteins and promote the expression of specific genes. On the other hand, they can improve cell adhesion properties and prevent fibroblasts from passing through the barrier membrane. Therefore, electrospinning has unique advantages in periodontal treatment. At present, many oral nanofibrous membranes with antibacterial, anti-inflammatory, and tissue regeneration properties have been prepared for periodontal treatment. First, this paper introduces the electrospinning process. Then, the commonly used polymers of electrospun nanofibrous membranes for treating periodontitis are summarized. Finally, different types of nanofibrous membranes prepared via electrospinning for periodontal treatment are presented, and the future evolution of electrospinning to treat periodontitis is described.

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Poly (Lactic Acid) membrane and Sedum dendroideum extract favors the repair of burns in rats

Abstract: Acquisition and interpretation of data, technical procedures, histopathological examinations, statistics analysis, manuscript preparation.

Cited by 8 publications

References 39 publications

Traditional Plants Used in Southern Brazil as a Source to Wound Healing Therapies

Traditional Plants Used in Southern Brazil as a Source to Wound Healing Therapies

Efficacy ofLobelia alsinoidesLam ethanolic extract on a third‐degree burn: An experimental study on rats

Electrospun Nanofibers for Periodontal Treatment: A Recent Progress

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