Effect of Arrabidaea chica extract against chemically induced breast cancer in animal model

Rocha, Keyla Borges Ferreira; Oliveira, Cláudia Nunes; Azevedo, Ítalo Medeiros; Macedo, Robson de; Medeiros, Aldo Cunha

doi:10.1590/s0102-865020190100000001

Cited by 10 publications

(10 citation statements)

References 26 publications

(29 reference statements)

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“…The elevation in WBCs is due to the inflammatory response in rats with large tumors that increases the risk of developing invasive breast cancer. 37 The results of Nguedia et al 14 were consistent with the present study.…”

Section: Discussionsupporting

confidence: 92%

Assessment of Wheat Germ Oil Role in the Prevention of Induced Breast Cancer in Rats

et al. 2022

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Breast cancer is the most predominant cause of death in women globally. The current study was performed to evaluate the possible protective role of wheat germ oil (WGO), wheat germ powder (WGP), and vitamin E (Vit E) against breast carcinoma induced by the environmental carcinogen 7,12-dimethylbenz[ a ]anthracene (DMBA) in Sprague Dawely albino rats. Eighty female rats were divided into eight groups, each of ten rats. All protective agents were taken 21 days prior to DMBA treatment. Group I served as the normal control. Group II received Vit E (100 mg/kg BW/d) by gavage. Group III was fed a 20% WGP enriched basal diet. Group IV received WGO (270 mg/kg BW/d) by gavage. Group V received DMBA (50 mg/kg body weight/subcutaneous injection). Group VI received Vit E + DMBA. Group VII received WGP + DMBA. Group VIII received WGO + DMBA. The investigation focused on bodyweights, complete blood picture (CBC), cancer antigen 15.3 (CA15.3), superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), and histopathological and immunohistochemical analyses. Results showed that all cancer protective agents significantly improved CBC parameters, proliferating cell nuclear antigen (PCNA), and the histopathology picture, with the best improvement in the WGO group. In addition, WGO, WGP, and Vit E decreased the CA15.3 and MDA levels and elevated both the SOD and CAT levels compared to the DMBA group. Consequently, supplementation with WGO, WGP, and Vit E protects against lipid peroxidation and oxidative stress and reduces breast cancer.

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Section: Discussionsupporting

confidence: 92%

Assessment of Wheat Germ Oil Role in the Prevention of Induced Breast Cancer in Rats

et al. 2022

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“…The results are in line with the outcomes of Rocha et al. (2019) who measured an increased level of AST after administering the chemotherapeutic drug to rats. Conclusively, the mushroom extract more effectively controlled the level of liver enzymes in rats with DMBA‐induced mammary carcinoma.…”

Section: Discussionsupporting

confidence: 91%

“…However, Rocha et al. (2019) and Arroyo‐Acevedo et al. (2020) reported more weight gain in rats upon the intake of plant polyphenols extract compared with rats receiving no intervention but DMBA.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the therapeutic potential of white button mushroom (Agaricus bisporus) against DMBA‐induced breast cancer in Sprague Dawley rats

et al. 2021

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The current research work was designed to investigate the protective effects of white button mushroom (Agaricus bisporus) against 7,12‐dimethylbenz[a]anthracene (DMBA)‐induced breast cancer. Breast cancer was induced in rats by the administration of a single dose of 50 mg/kg DMBA via gavage. The rats were divided into four groups: G1 (negative control group), G2 (positive control group), G3 (rats receiving mushroom extract), and G4 (rats administered with doxorubicin). The mushroom extract significantly (p < .001) improved the activity of antioxidant enzymes in carcinogenic rats. Moreover, the mushroom extract also prevented the increase in the concentration of tumor biomarkers that are CEA, CA 15.3, and CRP in experimental rats. Liver function enzymes were also raised in G2 and G4 compared with G3. Besides, the RBCs and Hb were also reduced significantly in G4 while in G3. The mushroom extract effectively controlled the level of RBCs and Hb. An improvement in lipid profile was also measured in mushroom extract receiving rats. Conclusively, the mushroom extract alleviated DMBA‐induced breast cancer potentially via improving antioxidants, reducing lipid peroxidation, and decreasing tumor biomarkers. Practical applications The present research study examined the antitumor potential of white button mushroom. The mushroom effectively prevented the increase in tumor biomarkers, reduction in antioxidant enzymes, and increase in lipid peroxidation in rats with DMBA‐induced breast cancer. The mushroom can be used as a potential source to prevent breast cancer and further research can be conducted to explore its anticancer mechanisms.

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“…However, a significant reduction was observed in the liver and hematologic toxicity of the ACE + 50% vincristine-treated group. Furthermore, the ACE-treated rats exhibited better albumin and transaminase levels probably because of the antioxidant components of ACE [57].…”

Section: Main Chemical Composition Of a Chicamentioning

confidence: 96%

A Review of the Phytochemistry and Pharmacological Properties of the Genus Arrabidaea

et al. 2022

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The genus Arrabidaea, consisting of ~170 species, belongs to the family Bignoniaceae, distributed around the Neotropics and temperate zone. The center of diversity of the family is in Brazil, where 56 genera and about 340 species exist. Most species of the genus Arrabidaea are traditionally utilized as diuretics and antiseptics, as well as for treating intestinal colic, diarrhea, kidney stones, rheumatoid arthritis, wounds, and enterocolitis. The genus is chemically diverse with different substance classes; most of them are triterpenes, phenolic acids, and flavonoids, and they exhibit valuable pharmacological properties, such as antitumor, antioxidant, leishmanicidal, trypanocidal, anti-inflammatory, and healing properties. This review presents information on the chemical constituents isolated from seven Arrabidaea species, and the pharmacological activities of the extracts, fractions and pure substances isolated since 1994, obtained from electronic databases. The various constituents present in the different species of this genus demonstrate a wide pharmacological potential for the development of new therapeutic agents, however its potential has been underestimated.

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Effect of Arrabidaea chica extract against chemically induced breast cancer in animal model

Cited by 10 publications

References 26 publications

Assessment of Wheat Germ Oil Role in the Prevention of Induced Breast Cancer in Rats

Assessment of Wheat Germ Oil Role in the Prevention of Induced Breast Cancer in Rats

Evaluating the therapeutic potential of white button mushroom (Agaricus bisporus) against DMBA‐induced breast cancer in Sprague Dawley rats

A Review of the Phytochemistry and Pharmacological Properties of the Genus Arrabidaea

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