Evaluating the therapeutic potential of white button mushroom (Agaricus bisporus) against DMBA‐induced breast cancer in Sprague Dawley rats

Abstract

The current research work was designed to investigate the protective effects of white button mushroom (Agaricus bisporus) against 7,12‐dimethylbenz[a]anthracene (DMBA)‐induced breast cancer. Breast cancer was induced in rats by the administration of a single dose of 50 mg/kg DMBA via gavage. The rats were divided into four groups: G1 (negative control group), G2 (positive control group), G3 (rats receiving mushroom extract), and G4 (rats administered with doxorubicin). The mushroom extract significantly (p < .001) improved the activity of antioxidant enzymes in carcinogenic rats. Moreover, the mushroom extract also prevented the increase in the concentration of tumor biomarkers that are CEA, CA 15.3, and CRP in experimental rats. Liver function enzymes were also raised in G2 and G4 compared with G3. Besides, the RBCs and Hb were also reduced significantly in G4 while in G3. The mushroom extract effectively controlled the level of RBCs and Hb. An improvement in lipid profile was also measured in mushroom extract receiving rats. Conclusively, the mushroom extract alleviated DMBA‐induced breast cancer potentially via improving antioxidants, reducing lipid peroxidation, and decreasing tumor biomarkers. Practical applications The present research study examined the antitumor potential of white button mushroom. The mushroom effectively prevented the increase in tumor biomarkers, reduction in antioxidant enzymes, and increase in lipid peroxidation in rats with DMBA‐induced breast cancer. The mushroom can be used as a potential source to prevent breast cancer and further research can be conducted to explore its anticancer mechanisms.

Exploring Therapeutic Potential of Pleurotus ostreatus and Agaricus bisporus Mushrooms against Hyperlipidemia and Oxidative Stress Using Animal Model

“…Additionally, the supplementation of white button and oyster mushroom extracts exhibited promising effects in lowering LDL and vLDL cholesterol, indicating their potential as natural interventions for dyslipidemia. These findings are consistent with [ 23 ] emphasizing the cholesterol-modulating properties of statins and selected mushroom extract. Overall, the findings of this study supported by previous researches [ 24 ] by demonstrating the detrimental effects of hypercholesterolemia on lipid profile parameters and potential beneficial effects of statin drugs and extracts of oyster and white button mushrooms in improving lipid profiles.…”

Anti‐breast‐cancer activity of self‐fermented Bovistella sinensis Lloyd extracts through the mitochondrial ROS ‐induced apoptosis in vitro

“…Breast cancer is one of the most common cancers and the leading cause of cancer‐related deaths among women around the world (Latif et al, 2021; Xu et al, 2017). Near 2.3 million women will be newly diagnosed with breast cancer was reported in 2020, which accounted for 11.7% of all cancer cases (Sung et al, 2021).…”