Ganoderma lucidum, a promising agent possessing antioxidant and anti-inflammatory effects for treating calvarial defects with graft application in rats

Abstract

Purpose: Ganoderma lucidum, a kind of mushroom used for its antioxidant, anti-inflammatory, and immunomodulatory activities, was investigated in the present study for its possible healing effect on calvarial defects with bone grafts.Methods:Wistar male rats (n = 30) were divided into 3 groups: 1) the control (defect) group (n = 10), 2) defect and graft group (n = 10), and 3) defect, graft, and G. lucidum treated group (n = 10). The G. lucidum was administered to the rats at 20 mL/kg per day via gastric lavage.Results:In the defect and graft group, osteonectin positive expression was observed in osteoblast and osteocyte cells at the periphery of the small bone trabeculae within the graft area. In the defect, graft, and G. lucidum treated group, osteonectin expression was positive in the osteoblast and osteocyte cells and positive osteonectin expression in new bone trabeculae. The expression of matrix metalloproteinase-9 (MMP-9) was positive in the inflammatory cells, fibroblast cells, and degenerated collagen fibril areas within the defect area.Conclusion:This study shows that, with its antioxidant and anti-inflammatory properties, G. Lucidum is an important factor in the treatment of calvarial bone defects.

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“…But the administration of total triterpenes significantly decreased the serum lipid peroxide level, thereby preventing the joint destruction. Investigations by other researchers also revealed the potential anti-inflammatory action of various extracts of Ganoderma lucidum in animals 5,6,7,8,9 . Both mycelium and fruiting bodies of Ganoderma lucidum were found to be highly beneficial against carrageenan-induced acute and formalin-induced chronic inflammation in mice 8,9 .…”

“…possess a significant anti-inflammatory effect against different inflammatory models in animals 5,6,7 . Earlier studies conducted in our laboratory also revealed the anti-peroxidative, anti-inflammatory, and anti-mutagenic activities of ethanol extract of the mycelium of Ganoderma lucidum 8 .…”

Multi-Pharmaceutical Activities of Chinese Herbal Polysaccharides in the Treatment of Pulmonary Fibrosis: Concept and Future Prospects

“…GIP can increase pathological lung tissue CAT (catalase), SOD (superoxide dismutation), GSH (glutathione), and GSH-Px (glutathione peroxidase) levels, simultaneously, reduce the content of MDA (malondialdehyde) and HYP in lung tissue (Chen et al, 2016). Later reports confirmed that ganoderma lucidum has obvious protective effect on oxidative damage caused by oxidants (Laçin et al, 2019;Lin and Deng, 2019). Ganoderic acid can treat renal fibrosis through TGF-β/Smad and MAPK signaling (Geng et al, 2020).…”

Improvement of cytotoxicity and necrosis activity of ganoderic acid a through the development of PMBN-A.Her2-GA as a targeted nano system

“…4 Its pharmacological properties include immune-modulating, anti-inammatory, anti-cancer, anti-diabetic, anti-oxidative, radical-scavenging, and anti-aging effects. [5][6][7] G. lucidum, contains more than 90% water, carbohydrate, crude fat, bre, and protein 8 . Moreover, it consists of diverse bioactive components such as terpenoids, steroids, phenols, glycoproteins, and polysaccharides.…”