Analysis of inflammatory and metabolic biomarkers in patients submitted to abdominoplasty after bariatric surgery

Abstract

Purpose: To evaluate the serum variations of Interleukins (Il) and CPR of abdominoplasties in post-bariatric patients and, to equate the homeostasis (HOMA) from the variations of glycemia and insulin to evolute the metabolic modifications. Methods: Fourteen women were submitted to abdominoplasties with weight loss after a gastroplasty. Levels of IL 4 , IL 6 , IL 10 , CRP, glycemia and insulin were obtained during the pre-operative, trans-operative, 24 hours post, 7 th and 14 th postoperative days. Results: The IL 4 was higher at 24 hours post-surgery, and after a moderate decrease, it remained high until the 14 th day. The IL 6 and CRP had an expressive increase during the trans-operative period. The CRP remained high, and the IL 6 decreased on the 7 th and 14 th days. The IL 10 increased during the transoperative period, and it posteriorly decreased to lower levels in comparison to the pre-operative period. The already increased glycemia during the pre-operative period was even higher during the trans-operative and then, returned to preliminary values on the 7 th and 14 th days after surgery. The HOMA accompanied the insulin. Conclusion: The inflammatory and glycemic serum levels decrease after abdominiplasty in obese post-bariatric patients.

Post-bariatric body contouring surgery: analysis of complications in 180 consecutive patients

“…The increase in bariatric procedures and the resulting deformities of the body contour, called dysmorphias, led to an increase in the number of patients after bariatric surgery seeking plastic surgery for physical and emotional rebalancing. With the popularization of plastic surgery and the improvement of operative techniques, the treatment of these patients has become more effective, achieving results that improve quality of life [12][13][14][15][16] .…”

Changes in Glucose Control and Lipid Levels Following Trunk-Based Body Contouring Surgery in Postbariatric and Nonbariatric Patients

“…Adipocytokines contribute to hunger and energy balance, highlighting the relationship between weight regain and metabolic levels. 6 , 8 , 15 Our report on weight control following BC showed that most patients (postbariatric and nonbariatric) tend to regain weight after achieving their low nadir following trunk-based BC. 20 Attaining proper weight control following BC may prevent long-term complications of metabolic syndrome and unfavorable changes in lipid profile.…”

“… 6 , 7 , 9 Most studies in which these laboratory values are analyzed do not have sufficient follow up to draw reliable conclusions. 8 …”

“… 6 , 7 Other studies evaluating these effects following BC are limited by short follow-up periods, small sample sizes, gender-specific cohorts, and assessment of all anatomic regions together. 8–15 The systematic review evaluating metabolic outcomes after trunk-based BC includes studies with mostly follow up of 3 months or less, several of which evaluate patients who underwent exclusively liposuction rather than true dermatolipectomy. 16 The review also does not distinguish between patients who previously underwent BS.…”

A novel immune-related genes signature after bariatric surgery is histologically associated with non-alcoholic fatty liver disease

“…IL10 is an anti-inflammatory cytokine released by monocytes/macrophages in adipose tissue. With the decrease of IL6 after BS, IL10 as the antagonistic anti-inflammatory cytokine of IL6 also decreased [ 40 ]. Abnormal activation of Toll-like receptors (TLRs) had been found to cause obesity-related systemic inflammation and associated comorbidities in obese rats [ 41 ].…”