An experimental study on the preventive effects of N-acetyl cysteine and ozone treatment against contrast-induced nephropathy

Öztürk, Ömür; Eroğlu, Hüseyin Avni; Üstebay, Sefer; Kuzucu, Mehmet; Adalı, Yasemen

doi:10.1590/s0102-865020180060000005

Cited by 15 publications

(10 citation statements)

References 24 publications

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“…Although this condition is in accordance with different studies reporting that APAP induced renal damage is consistent with acute tubular necrosis [41,42] , we conclude that our findings may be due to the beneficial effects of ozone in increasing tissue antioxidant enzyme activity and reducing tissue damage [37] . These results are also in agreement with the findings of a study investigating the protective effect of ozone on the kidneys and reporting its beneficial effects on the regulation of the antioxidant defense system [43] . The main finding of this study is that ozone alone or in combination with L-carnitine decreases tissue MDA levels due to APAP toxicity and increases tissue antioxidant parameter levels.…”

Section: Discussionsupporting

confidence: 92%

Asetaminofen Toksisitesinde Ozon ve L-Karnitinin Böbrek MDA, GSH ve GSHPx Düzeylerine Etkisi

Eroğlu¹,

Makav²,

Adalı³

et al. 2019

Kafkas Univ Vet Fak Derg

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This study aimed to determine the therapeutic effects of medical ozone and L-carnitine therapy on acetaminophen (APAP)-induced kidney damage by evaluating malondialdehyde (MDA), glutathione (GSH), and GSHPx levels. In this study, 56 rats were randomized into 8 groups with 7 rats in each group. Kidney injury was induced by the administration of a single dose N-acetyl-p-aminophenol (1 g/kg) orally. Therapeutic ozone (0.7 mg/kg) and L-carnitine (500 mg/kg) were administered intraperitoneally. After the therapy, the rat kidneys were homogenized, and the tissue MDA, GSH, and GSHPx levels were measured. Compared to the control groups, there were higher MDA levels in the kidney tissues only in the "APAP, " "APAP + Ozone, " and "APAP + Ozone + L-carnitine" groups (P<0.001). Besides, the decrease in the GSH and GSHPx levels of the kidney tissues in the study groups were significant compared to the control groups, and the highest decreases were observed in the "APAP, " "APAP + Ozone" and "APAP + Ozone + L-carnitine" groups (P<0.001). Findings obtained from this study revealed that acetaminophen toxicity caused oxidative damage in the examined kidney tissues, and L-carnitine and/ or ozone applications for protective purposes decreased MDA levels, a product of lipid peroxidation, and increased tissue GSH levels thru GSHPx antioxidant enzyme activity. In this context, the most important protective effect was observed in the group where L-carnitine and ozone were administrated together.

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Section: Discussionsupporting

confidence: 92%

Asetaminofen Toksisitesinde Ozon ve L-Karnitinin Böbrek MDA, GSH ve GSHPx Düzeylerine Etkisi

Eroğlu¹,

Makav²,

Adalı³

et al. 2019

Kafkas Univ Vet Fak Derg

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“… Histopathological alterations : improving in Renal tubular injury, hemorrhage, cast formation. ( Ozturk et al, 2018 ) Preconditioning : Major Ozonated Autohemotherapy in 5 m blood rabbit, before ischemia/reperfusion. Reduction : interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), white blood cells, neutrophil to lymphocyte ratio (NLR), ischemia-modified albumin (IMA), total oxidant status (TOS), oxidative stress index (OSI).…”

Section: Effect Of Ozone Oxidative Preconditioning On Oxidative Stresmentioning

confidence: 99%

Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders

Scassellati

Galoforo

Bonvicini

et al. 2020

Ageing Research Reviews

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Highlights Aging and neurodegenerative diseases are characterized by complex and multifactorial aetiology and challenges regarding treatments efficacy and costs persist. Oxygen-ozone (O 2 -O 3 ) therapy is a non-invasive, non-pharmacological, low cost and no-side effect procedure based on antioxidant capacity of O 3 . A plethora of scientific evidence supports other crucial properties of O 3 in physiopathological processes. Nrf2 is one of the principal molecular signalling on which O 3 exercises its antioxidant/anti-apoptotic/pro-autophagy effects, involved in aging and in neurodegenerative disorders. This review provides a consistent rationale to implement future clinical studies to apply the O 2 -O 3 treatment along with other antioxidants (polyphenols, mushrooms) in aging and in neurodegeneration.

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“…MDA content of CIN rats was significantly higher than that of sham rats, while SOD activity was significantly reduced (P < 0:05). Although the pathological mechanism of CIN has not been clearly elucidated, various studies have investigated that oxidative stress is an important cause of CIN [6,44]. The direct toxicity of contrast agents leads to the ROS production, while the oxidative stress caused by the increasing free radicals leads to the apoptosis of renal tubules and glomerular cells [45].…”

Section: International Journal Of Polymer Sciencementioning

confidence: 99%

“…Previous studies reported that CIN is a complex pathological process related to multiple pathological cascades. Oxidative stress [6,7], renal ischemia [8], endothelial dysfunction [9], inflammation [10,11], apoptosis [12][13][14], and tubular transport dysfunction [15] may be involved in the pathogenesis of CIN. Increasing studies point out that reactive oxygen species (ROS) play the key role in CIN development [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Polysaccharides Extracted from Sargassum fusiforme and Its Effective Prevention of Contrast-Induced Nephropathy via Enhancing Antioxidant Capacity

Dai

Zhou

Jiang

et al. 2019

International Journal of Polymer Science

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Contrast-induced nephropathy (CIN) is a common complication in patients with coronary arteriography, and oxidative stress is involved in the CIN pathogenesis. Sargassum fusiforme (SF) is a brown seaweed with medicinal value, and its polysaccharides have good antioxidant activity. In this study, the crude polysaccharides (cSFP-C) were extracted by cold water, precipitated by ethanol, purified by CaCl2, and detected with high contents of sulfate radical and fucose. cSFP-C is composed of glucose, glucuronic acid, xylose, rhamnose, mannose, galactose, and fucose with a molar ratio of 1.0 : 0.4 : 5.6 : 1.2 : 1.7 : 12.3 : 56.1. The cSFP-C has the typical absorption of polysaccharides. Antioxidation assays in vitro showed that cSFP-C exhibited superoxide radical scavenging activity which was better than the hot water-extracted crude polysaccharides (cSFP-H). 20 rats were divided into 4 groups (n=5): sham group; CIN group; CIN+cSFP-C group, and cSFP-C group. The CIN+cSFP-C group and cSFP-C group were pretreated intragastrically with cSFP-C at a dose of 9.45 g/kg twice daily for 5 consecutive days. Then, the CIN group and CIN+cSFP-C group were given indomethacin to develop CIN. The in vivo results showed that cSFP-C could decrease blood creatinine and urea nitrogen, inhibiting pathological injury in the renal tissues. The MDA content of renal tissues was decreased, while the activity of SOD was increased. The crude sulfated polysaccharides extracted from S. fusiforme have a renoprotective effect on oxidative stress to alleviate the kidney injury in CIN rats.

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An experimental study on the preventive effects of N-acetyl cysteine and ozone treatment against contrast-induced nephropathy

Abstract: The N-acetyl cysteine and ozone treatment may alleviate the biochemical and histopathological deleterious effects of contrast-induced nephropathy via enhancement of total antioxidant capacity and decreasing oxidative stress.

Cited by 15 publications

References 24 publications

Asetaminofen Toksisitesinde Ozon ve L-Karnitinin Böbrek MDA, GSH ve GSHPx Düzeylerine Etkisi

Asetaminofen Toksisitesinde Ozon ve L-Karnitinin Böbrek MDA, GSH ve GSHPx Düzeylerine Etkisi

Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders

Characterization of Polysaccharides Extracted from Sargassum fusiforme and Its Effective Prevention of Contrast-Induced Nephropathy via Enhancing Antioxidant Capacity

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