Evaluation of polyamide surgical mesh as an abdominal ventral implant in rabbits

Dória, Renata Gebara Sampaio; Freitas, Sílvio Henrique de; Hayasaka, Yumi de Barcelos; Hage, Maria Cristina Ferrarini Nunes Soares; Strefezzi, Ricardo de Francisco; Carregaro, Adriano Bonfim; Reginato, Gustavo Morandini; Ambrósio, Carlos Eduardo; Müller, Alois Foltran

doi:10.1590/s0102-865020180050000008

Cited by 4 publications

(3 citation statements)

References 22 publications

(33 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The author's findings were in accordance with the observation of Singh et al, (2008) after abdominal reconstruction with porcine bladder, diaphragm and dermal matrix in rabbits at day 7. Doria et al, (2018) found that inflammatory reaction had mostly subsided by 180 days after surgical repair of abdominal wall defects.…”

Section: Xenogenic Acellular Pericardium Matrix Of Caprine and Porcin...mentioning

confidence: 99%

Xenogenic Acellular Pericardium Matrix of Caprine and Porcine Origin for Abdominal Wall Reconstruction in Rabbits

Padhan¹,

Nath²,

Sarma³

et al. 2022

IJAR

View full text Add to dashboard Cite

Background: The abdominal wall defects require urgent medical attention owing to the voluminous visceral content and uneven wound edges, which remains a clinical challenge for the surgeon. In the present study, xenogenic porcine and caprine acellular pericardium matrix was evaluated for surgical reconstruction of the induced abdominal wall in rabbits. Methods: All total eighteen adult rabbits were divided into three equal groups. The defects were corrected with acellular caprine and porcine pericardium matrix in Group A and B, respectively and Group C was kept as control. Various parameters viz clinical, gross evaluation of surgical wound, degree of adhesion and histopathological changes were evaluated as per standard methods. Result: Clinical parameters and gross changes of the surgical wound showed significant changes on the 3rd and 5th day in all the groups. TLC, Serum Alkaline Phosphatase and Total Protein showed significant variation in Group A and B on the 10th day. Macroscopic and histopathological evaluation of implanted mesh has shows better host tissue proliferation in both the groups. Acellular caprine and porcine pericardium can be good options as bio-mesh for the repair of the abdominal wall and the subject may be considered for in-depth studies and further research programs.

show abstract

Section: Xenogenic Acellular Pericardium Matrix Of Caprine and Porcin...mentioning

confidence: 99%

Xenogenic Acellular Pericardium Matrix of Caprine and Porcine Origin for Abdominal Wall Reconstruction in Rabbits

Padhan¹,

Nath²,

Sarma³

et al. 2022

IJAR

View full text Add to dashboard Cite

show abstract

“…Considering the biocompatibility of LCM, most studies examined the effects of LCM directly in vivo (either animal or human) showing the success of LCM [ 2 – 4 , 12 , 13 ]. The concern of performing exclusively in vivo studies resides in the fact that there is a huge variation in this type of experiment as different animal species are used (rabbit, pig, rat) and therefore comparison is difficult.…”

Section: Introductionmentioning

confidence: 99%

In vitro characterisation of low-cost synthetic meshes intended for hernia repair in the UK

Grillo

Hyder²,

Mudera

et al. 2021

Hernia

View full text Add to dashboard Cite

Purpose Low-cost meshes (LCM) were repurposed for the repair of hernias in the developing world. In vivo studies have shown LCM to have comparable results to commercial meshes (CM) at a fraction of the cost. However, little has been done to characterise the mechanical and biocompatible properties of LCM, preventing its clinical use in the UK. The objectives of the research are to assess mechanical and ultrastructural properties of two UK-sourced low-cost meshes (LCM) and the characterisation of the LCMs in vitro biocompatibility. Methods Mechanical properties of the two LCM were measured through uniaxial tensile test and ultrastructure was evaluated with Scanning Electron Microscopy. LIVE/DEAD® Viability/Cytotoxicity Assay kit and alamarBlue were used to assess cellular viability and proliferation, respectively. Images were acquired with a fluorescence microscope and analysed using ImageJ (NIH, USA). Results LCM1 and LCM2 were both multifilament meshes, with the first having smaller pores than the latter. LCM1 exhibited significantly higher tensile strength (p < 0.05) than LCM2 but significantly lower extensibility (p < 0.0001), while Young’s Modulus of the two samples was not significantly different. No significant difference was found in the cellular viability and morphology cultured in LCM1 and LCM2 conditioned media. Metabolic assay and fluorescence imaging showed cellular attachment and proliferation on both LCMs over 14 days. Conclusion The characterisation of the two UK-sourced LCMs showed in vitro biocompatibility and mechanical and ultrastructural properties comparable to the equivalent CM. This in vitro data represents a step forward for the feasibility of adopting LCM for surgical repair of hernias in the UK.

show abstract

“…They are constantly in high demand and scientist are seeking additional polymeric carriers for this application [2]. Researchers have documented the attractive clinical application, biocompatibility and potent drug release modulating properties of different aliphatic polyamides [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44]. Yet, there is still not much information regarding their use as extended release drug carriers.…”

Section: Introductionmentioning

confidence: 99%

In vitro characterization of a synthetic polyamide-based erodible compact disc for extended drug release

Adeleke

2020

SN Appl. Sci.

View full text Add to dashboard Cite

Evaluation of polyamide surgical mesh as an abdominal ventral implant in rabbits

Abstract: Polyamide surgical mesh for hernioplasty presents, in rabbits, excellent biocompatibility, with minimal body adverse reactions and low cost.

Cited by 4 publications

References 22 publications

Xenogenic Acellular Pericardium Matrix of Caprine and Porcine Origin for Abdominal Wall Reconstruction in Rabbits

Xenogenic Acellular Pericardium Matrix of Caprine and Porcine Origin for Abdominal Wall Reconstruction in Rabbits

In vitro characterisation of low-cost synthetic meshes intended for hernia repair in the UK

In vitro characterization of a synthetic polyamide-based erodible compact disc for extended drug release

Contact Info

Product

Resources

About