Abstract:Schinus terebinthifolius Raddi (Aroeira) leaves oil attenuatesinflammatory responses in cutaneous wound healing in mice 1
AbstractPurpose: To investigated the inflammatory, angiogenic and fibrogenic activities of the Schinus terebinthifolius Raddi leaves oil (STRO) on wound healing.
Methods:The excisional wound healing model was used to evaluate the effects of STRO. The mice were divided into two groups: Control, subjected to vehicle solution (ointment lanolin/ vaseline base), or STRO-treated group, administer… Show more
“…[19] The plant is popularly used for treating wounds, rheumatism, respiratory disorders and even in the prevention of cancer, due to its antioxidant effects. [18,20] Considering the importance of research on the biological properties of essential oils, the objective of this work was to evaluate the chemical profile and biological activities of the oil from C. aschersoniana, S. terebinthifolia, and C. amoenum. In addition, a study of the association of C. aschersoniana oil with commercial antifungal agents was carried out.…”
The purpose of this work was to determine the chemical composition and evaluate the antichemotactic, antioxidant, and antifungal activities of the essential oil obtained from the species Cryptocarya aschersoniana Mez, Cinnamomum amoenum (Ness & Mart.) Kosterm., and Schinus terebinthifolia Raddi, as well as the combination of C. aschersoniana essential oil and terbinafine against isolates of dermatophytes. Allo‐aromadendrene, bicyclogermacrene, and germacrene B were identified as major compounds in essential oils. The essential oil of C. aschersoniana shown 100 % inhibitory effect on leukocyte migration at the concentration of 10 μg/mL while S. terebinthifolia oil presented 80.1 % inhibitory effect at the same concentration. Only S. terebinthifolia oil possessed free‐radical‐scavenging activity which indicates its antioxidant capacity. The essential oils were also tested against fungal isolates of dermatophyte species (Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum canis and Microsporum gypseum), resulting in MIC ranging from 125 μg/mL to over 500 μg/mL. C. aschersoniana oil combined with terbinafine resulted in an additive interaction effect. In this case, the essential oil may act as a complement to conventional therapy for the topical treatment of superficial fungal infections, mainly because it is associated with an anti‐inflammatory effect.
“…[19] The plant is popularly used for treating wounds, rheumatism, respiratory disorders and even in the prevention of cancer, due to its antioxidant effects. [18,20] Considering the importance of research on the biological properties of essential oils, the objective of this work was to evaluate the chemical profile and biological activities of the oil from C. aschersoniana, S. terebinthifolia, and C. amoenum. In addition, a study of the association of C. aschersoniana oil with commercial antifungal agents was carried out.…”
The purpose of this work was to determine the chemical composition and evaluate the antichemotactic, antioxidant, and antifungal activities of the essential oil obtained from the species Cryptocarya aschersoniana Mez, Cinnamomum amoenum (Ness & Mart.) Kosterm., and Schinus terebinthifolia Raddi, as well as the combination of C. aschersoniana essential oil and terbinafine against isolates of dermatophytes. Allo‐aromadendrene, bicyclogermacrene, and germacrene B were identified as major compounds in essential oils. The essential oil of C. aschersoniana shown 100 % inhibitory effect on leukocyte migration at the concentration of 10 μg/mL while S. terebinthifolia oil presented 80.1 % inhibitory effect at the same concentration. Only S. terebinthifolia oil possessed free‐radical‐scavenging activity which indicates its antioxidant capacity. The essential oils were also tested against fungal isolates of dermatophyte species (Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum canis and Microsporum gypseum), resulting in MIC ranging from 125 μg/mL to over 500 μg/mL. C. aschersoniana oil combined with terbinafine resulted in an additive interaction effect. In this case, the essential oil may act as a complement to conventional therapy for the topical treatment of superficial fungal infections, mainly because it is associated with an anti‐inflammatory effect.
“…In traditional medicine, this plant is used to treat skin wounds and ulcers, tumors, diarrhea, arthritis as well as urinary and respiratory tract infections (Brandão et al, 2006). Various pharmacological activities have been described for this plant, including antimicrobial (Silva et al, 2017a), antiulcerogenic (Carlini et al, 2010), anticancer (Silva et al, 2017b), antihistamine (Nunes-Neto et al, 2017), antihypertensive (Glória et al, 2017), antihyperalgesic (Piccinelli et al, 2015), wound healing (Estevão et al, 2017), anti-inflammatory (Silva et al, 2017b) and antioxidant (Rocha et al, 2017) activities in different models.…”
Schinus terebinthifolius Raddi, commonly known as Brazilian peppertree, is a plant species widely used in Brazilian traditional medicine for various purposes. The objective of this study was to assess the microbiological quality, safety, chemical profile as well as antioxidant and antidiabetic potentials of different parts of S. terebinthifolius. Microbiological analysis of the methanolic extracts of the roots (MESR), stem bark (MESB) and leaves (MESL) of S. terebinthifolius showed no microbial growth. The concentrations of phenolic compounds, phenolic acids and flavonoids were determined by spectrophotometry. The phenolic compounds of the MESL were identified by liquid chromatography coupled to a diode array detector and mass spectrometer (LC-DAD-MS). The antioxidant activities of the extracts were analyzed by 2,2-diphenyl-1-(2,4,6-trinitrophenyl)hydrazyl radical (DPPH%), 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) radical (ABTS% +), fluorescence recovery after photobleaching (FRAP), reducing power, β-carotene bleaching and malondialdehyde (MDA) assays in human erythrocytes. The antidiabetic properties of the extracts were demonstrated in vitro by their inhibition of the α-glucosidase enzyme and their anti-glycation activity via fructose and glyoxal. After showing no acute toxicity in vivo, MESL was able to lower postprandial glycemia after glucose overload in normoglycemic mice as well as the water and feed intake, liver weight, glycemia and serum levels of glycated hemoglobin, aspartate transaminase (AST) and alanine transaminase (ALT) in diabetic mice. Overall, S. terebinthifolius extracts showed microbiological safety along with antioxidant and antidiabetic activities, likely mediated by its chemical constituents, such as gallic acid, gallotannins and glycosylated flavonols.
“…In addition, EOpp is mainly composed of monoterpenes, 24,28,40 and this chemical compound has antiseptic action, 20 which can contribute for many of the interviewees to relate the aroma of EOpp to astringent and to the drying sensation that EO brought,It dried me up, I smelled it a lot, it dried the tongue. (I14)That place on my tongue, the moment I smell it, I feel it dry out.…”
Schinus terebinthifolius Raddi (Brazilian pepper tree or ‘aroeira’) is a native Brazilian tree, which its different parts are used medicinally for several applications, and its fruits are known as pink pepper. Composed mainly by monoterpenes, pink pepper's essential oil (EOpp) presents cytotoxic, antioxidant, insecticidal, cicatrizant, fungicidal, bactericidal and antimicrobial activity. It is known that there exists some literature, which describes psycho‐emotional effects, as well as symbolic aspects related to the use of essential oils (EOs) in clinical practice. However, there is a lack of current scientific studies that address these effects described in the literature, resulting from the stimulus via inhalation, as well as if it can interfere in the effectiveness of treatments with EOs. This research aimed to describe the perceptions and psychological associations of UNISUL's students of Naturology, when inhaling EOpp. This is a qualitative, descriptive, exploratory and field research. This research was conducted with 30 participants in individual in‐depth interviews. The inhalation of EOpp was related to the perception of physical sensations such as relaxation, sedation and improvement of breathing, as well as discomfort in the respiratory system, such as nose stinging; childhood memories and other past recollections, feelings of comfort, welcome, warmth, tranquility, calm, well‐being and peace; and improvement of self‐perception, sense of presence and decreased thoughts. It was possible to conclude that most of the feelings and emotions expressed by the interviewed participants were more directly related to the physical sensations and memories that emerged with the inhalation of EOpp, than with EOpp itself.
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