Effect of aqueous extract of the leaves of Baccharis trimera on the proliferation of hepatocytes after partial hepatectomy in rats

Lima, Sônia Oliveira; Figueiredo, Maria Bernadete Galrão de Almeida; Santana, Vanessa Rocha de; Santana, Danillo Primo Andrade; Nogueira, Matheus de Souza; Porto, E. S.; Andrade, Renata Lima Batalha de; Santos, Jessica Macêdo; Albuquerque, Ricardo Luiz Cavalcanti de; Cardoso, Juliana Cordeiro

doi:10.1590/s0102-865020170040000001

Cited by 6 publications

(7 citation statements)

References 21 publications

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“…Preclinical studies of B. trimera reported hypocholesterolemic, antiinflammatory, antiulcerogenic, antifungal, antibacterial, antiallergic, and anticarcinogenic activity (Alonso 1998, Lívero et al 2016a, Lima et al 2017. B. trimera also decreases adipogenesis and has antioxidant activity that can reduce lipid peroxidation, endothelial dysfunction, and cholesterol oxidation, a limiting step in the development of atherosclerosis (Pádua et al 2010, Hurrell et al 2015, Sabir et al 2017, Nascimento et al 2017.…”

Section: An Acad Brasmentioning

confidence: 99%

Hepato- and cardioprotective effects of Baccharis trimera (Less.) DC. against multiple risk factors for chronic noncommunicable diseases

Mendes¹,

Silva²,

Silva

et al. 2021

An. Acad. Bras. Ciênc.

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Cardiovascular diseases are associated with high morbidity and mortality worldwide and have several risk factors, including dyslipidemia, smoking, and hypertension. Studies have evaluated isolated risk factors in experimental models of cardiovascular disease, but few preclinical studies have assessed associations between multiple risk factors. In the present study, hypertensive Wistar rats (Goldblatt 2K1C model) received a 0.5% cholesterol diet and were exposed to tobacco smoke for 8 weeks.During the last 4 weeks, the animals were treated with vehicle, an ethanol-soluble fraction of B. trimera (30, 100, and 300 mg/kg), or simvastatin + enalapril. A group of normotensive, non-dyslipidemic, and non-smoking rats was treated with vehicle. The levels of aspartate aminotransferase, alanine aminotransferase, urea, creatinine, and hepatic and fecal lipids, blood pressure, and mesenteric arterial bed reactivity were evaluated. Cardiac, hepatic, and renal histopathology and tecidual redox state were also investigated. Untreated animals exhibited signifi cant changes in blood pressure, lipid profi le, and biomarkers of heart, liver, and kidney damage. Treatment with B. trimera reversed these changes, with effects that were similar to simvastatin + enalapril. These fi ndings suggest that B. trimera may be promising for the treatment of cardiovascular and hepatic disorders, especially disorders that are associated with multiple risk factors.

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Section: An Acad Brasmentioning

confidence: 99%

Hepato- and cardioprotective effects of Baccharis trimera (Less.) DC. against multiple risk factors for chronic noncommunicable diseases

Mendes¹,

Silva²,

Silva

et al. 2021

An. Acad. Bras. Ciênc.

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“…Liver cells respond positively to some herbal drugs. These include Baccharis trimera, picroliv, ellagic acid and curcumin 4,5 . The positive effects of TQ on liver are also known [6][7][8] .…”

Section: ■ Discussionmentioning

confidence: 99%

Effects of thymoquinone and curcumin on the regeneration of rat livers subject to 70% hepatectomy

et al. 2018

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“…[55] The animals that received a single dose of CCl 4 after 15 days of oral treatment with the extract at doses of 300 and 600 mg/kg showed a dose-dependent decrease in ALT activity, lipid peroxidation and protein carbonylation in liver tissue. Lima et al [57] demonstrated the restoration of liver mass in rats administrated with an infusion obtained from leaves of B. crispa (100 mg/ kg, p.o. ), 24 h after undergoing a partial hepatectomy.…”

Section: Baccharis Crispa Sprengmentioning

confidence: 99%

“…In Brazil, several plants with an intense bitter taste are used in folk medicine as tonics for digestive system functions, and they are included in phytomedicines prepared by local laboratories and in home remedies. [149] Moreover, the Brazilian population has a long history of using bitter medicinal plants to relieve liver diseases, including the widely-distributed species B. crispa and Phyllanthus niruri L. [57] Twenty-two species were listed in the present work as bitter tonics, among which the Simaroubaceae family accounted for four species: Quassia amara L. ('quina'), [25][26][27][28]40,41] Simaba ferruginea A.St.-Hil. ('calunga'), [11,25] Coutarea hexandra (Jacq.)…”

Section: Quassia Amara Lmentioning

confidence: 99%

Hepatoprotective Native Plants Documented in Brazilian Traditional Medicine Literature: Current Knowledge and Prospects

Arbo

Konrath

2022

Chemistry & Biodiversity

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The native flora of Brazil covers a large biodiversity of plants, some of which have important pharmacological properties. Ethnobotanical studies have established that the folk use of plants for hepatobiliary disorders is very common in Brazil. This review aimed to compile, describe and discuss the main native Brazilian medicinal plants used as hepatoprotective agents listed on 25 books by authors from various regions in the country. Based on the 153 species found, a comprehensive analysis of the most relevant scientific studies is presented, including Piper umbellatum, Echinodorus macrophyllus, Fevillea trilobata and Achyrocline satureioides. Some medicinal plants share both a large number of citations and scientific evidence to corroborate their hepatoprotective effects, including Solanum paniculatum, Baccharis crispa and Phyllanthus niruri, which could be of interest to develop new phytomedicines. Additionally, some active ingredients are indicated as being responsible for the liver protective effects described, particularly phenolic compounds (flavonoids, coumestans and lignans).

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Effect of aqueous extract of the leaves of Baccharis trimera on the proliferation of hepatocytes after partial hepatectomy in rats

Abstract: DAdministration of aqueous extract of the leaves of Baccharis trimera 100 mg/kg of animal has a significant positive effect on liver regeneration in rats, 24 hours after hepatectomy (70%).

Cited by 6 publications

References 21 publications

Hepato- and cardioprotective effects of Baccharis trimera (Less.) DC. against multiple risk factors for chronic noncommunicable diseases

Hepato- and cardioprotective effects of Baccharis trimera (Less.) DC. against multiple risk factors for chronic noncommunicable diseases

Effects of thymoquinone and curcumin on the regeneration of rat livers subject to 70% hepatectomy

Hepatoprotective Native Plants Documented in Brazilian Traditional Medicine Literature: Current Knowledge and Prospects

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