Antioxidant, α-amylase and α-glucosidase inhibitory activities of Cedrela sinensis (A. Juss) leaf with ethanol extract concentration

WU, YingJinZhu; Han, Young-Sil; Kim, Myung‐Hyun

doi:10.1590/fst.89122

Cited by 4 publications

(4 citation statements)

References 43 publications

(48 reference statements)

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“…Tác dụng ức chế enzym α-amylase của cao chiết tổng và các cao chiết phân đoạn của rễ CG được đánh giá theo phương pháp của Wu và cộng sự với một số hiệu chỉnh [11]. Các cao chiết được hòa tan trong DMSO và pha loãng với dung dịch đệm phosphat (pH = 6,9).…”

Section: Phương Pháp đáNh Giá Hoạt Tính ứC Chế Enzym α-Amylaseunclassified

Evaluation of Anti--amylase and Anti--glucosidase Activity of Canna x Generalis L.H Bailey & E.Z Bailey Rhizome

Thi Van Anh,

Hong Luyen

2024

MPS

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Canna x generalis L.H Bailey & E.Z Bailey (CG) has been used as folk medicine to treat different diseases. However, scientific information about the pharmacological effects and chemical composition of this plant is still very limited. This study aims to evaluate for the first time the α-amylase and α-glucosidase inhibitory activity of CG rhizome extracts. The rhizome part of CG was extracted with ethanol and then fractionated with n-hexane, ethyl acetate, and water. The total extract and fractions were evaluated for their inhibitory effects on α-amylase and α-glucosidase enzymes in vitro. The results showed that the ethyl acetate fraction had the strongest inhibitory activity against α-amylase and α-glucosidase with IC50 values of 53.19 ± 2.79 and 95.83 ± 6.26 µg/mL, respectively. Therefore, the rhizome part of the CG plant, especially the ethyl acetate fraction, is a potential natural source for searching for active ingredients to prevent and treat diabetes.

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Section: Phương Pháp đáNh Giá Hoạt Tính ứC Chế Enzym α-Amylaseunclassified

Evaluation of Anti--amylase and Anti--glucosidase Activity of Canna x Generalis L.H Bailey & E.Z Bailey Rhizome

Thi Van Anh,

Hong Luyen

2024

MPS

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“…The α-amylase inhibiting effects of the total extract and fractions of C. edulis rhizome were evaluated using the previously described method by Wu et al (2022) with some modifications. The extracts were dissolved in DMSO and diluted to obtain final concentrations of 5, 25, 50, 100, 200 µg/mL.…”

Section: Determination Of α-Amylase Inhibiting Effectmentioning

confidence: 99%

α-amylase and α-glucosidase inhibiting effects of Canna edulis Ker Gawl rhizome

Van Anh,

Hong Luyen

2023

Vietnam J. Biotechnol.

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Screening inhibitors of α-amylase and α-glucosidase from medicinal plants is a topic of interest in the world. Canna edulis Ker Gawl is an important rhizome plant belonging to the genus Canna of the family Cannaceae. It is traditionally used to treat many conditions such as gonorrhea, pain, bruises, diarrhea, hepatitis, chest pain and heart diseases. The potential of this plant in the treatment and prevention of diabetes has rarely been documented. This study reports, for the first time, α-amylase and α-glucosidase inhibiting effects and the phytochemical profile of the rhizome part of C. edulis.C. edulis rhizome was extracted with 96% ethanol, and then successively fractionated with n-hexane, ethyl acetate and water. α-amylase and α-glucosidase inhibiting assays were performed to investigate the enzyme inhibitory activities of the total extract and fractions. Qualitative phytoconstituents were analyzed using chemical reactions. The results showed that all extract and fractions had α-amylase and α-glucosidase inhibiting effects in a dose dependent manner. The ethyl acetate fraction exhibited the strongest inhibiting activities against both enzymes (IC50, 45.24 ± 2.90 and 90.09 ± 6.70 mg/mL for α-amylase and α-glucosidase inhibiting assays, respectively) and its effects were significantly higher than the positive control (p < 0.05). The water fraction showed the lowest effects. C. edulis rhizome contained abundant secondary metabolites including cardiac glycosides, cholesterols, glycosides, flavonoids, sterol and triterpenes, tannins, steroids, saponins, coumarins and proteins. All these secondary metabolites, except for saponin, were found in the ethyl acetate fraction. C. edulis rhizome could serve as a potential candidate to find novel anti-α-amylase and anti-α-glucosidase agents and to develop supplementary products for controlling hyperglycemia.

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“…α-Amylase inhibition activities of the total extract and fractions of the aerial part of CG were determined following the previous method described by Wu et al with some modifications. 17 The extracts were dissolved in DMSO and diluted to obtain final concentrations of 5, 25, 50, 100, 200 g/mL. α-Amylase (0.5 U/mL) was prepared in phosphate buffer (pH = 6.9).…”

Section: Determination Of α-Amylase Inhibitory Activitymentioning

confidence: 99%

Inhibitory Effects on α-Amylase and α-Glucosidase and Phytochemical Profiling of the Aerial Part of Canna x generalis L.H Bailey & E.Z Bailey

2023

TJNPR

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Several studies have reported pharmacological effects of C. warszewiczii and C. edulis such as antimalarial, antibacterial, antithrombotic, antioxidant and antiinflammatory activity. Bioactive flavonoids and phenolic compounds were isolated from C. edulis. 8,[10][11][12][13] In addition, Xie et al. documented the potential inhibition of αglucosidase of lignan from C. edulis ker residue. 14 However, scientific data on phytochemicals and biological effects of CG are minimal. The study by Mahmoud et al. reported the therapeutic potential against ulcerative colitis of CG rhizomes and identified its major phytoconstituents. 15 Recently, we documented the antithrombotic and antioxidant activity, isolated several bioactive compounds from aerial CG. 16 Nevertheless, the therapeutic potential of CG in managing diabetes has not been studied yet. This study aimed to evaluate the inhibitory effects on α-amylase and α-glucosidase, phytochemicals, total flavonoid content (TFC) and total phenolic content (TPC) of extracts from the aerial part of CG.

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Antioxidant, α-amylase and α-glucosidase inhibitory activities of Cedrela sinensis (A. Juss) leaf with ethanol extract concentration

Abstract: Materials and methods Sample preparation and extractionCedrela sinensis cultivated in Muan, South Korea was used as samples in this experiment. Cedrela sinensis leaf was ground and

Cited by 4 publications

References 43 publications

Evaluation of Anti--amylase and Anti--glucosidase Activity of Canna x Generalis L.H Bailey & E.Z Bailey Rhizome

Evaluation of Anti--amylase and Anti--glucosidase Activity of Canna x Generalis L.H Bailey & E.Z Bailey Rhizome

α-amylase and α-glucosidase inhibiting effects of Canna edulis Ker Gawl rhizome

Inhibitory Effects on α-Amylase and α-Glucosidase and Phytochemical Profiling of the Aerial Part of Canna x generalis L.H Bailey & E.Z Bailey

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