Inhibitory Effects on α-Amylase and α-Glucosidase and Phytochemical Profiling of the Aerial Part of Canna x generalis L.H Bailey & E.Z Bailey

Abstract

Several studies have reported pharmacological effects of C. warszewiczii and C. edulis such as antimalarial, antibacterial, antithrombotic, antioxidant and antiinflammatory activity. Bioactive flavonoids and phenolic compounds were isolated from C. edulis. 8,[10][11][12][13] In addition, Xie et al. documented the potential inhibition of αglucosidase of lignan from C. edulis ker residue. 14 However, scientific data on phytochemicals and biological effects of CG are minimal. The study by Mahmoud et al. reported the therapeutic potential against ulcerative colitis of CG rhizomes and identified its major phytoconstituents. 15 Recently, we documented the antithrombotic and antioxidant activity, isolated several bioactive compounds from aerial CG. 16 Nevertheless, the therapeutic potential of CG in managing diabetes has not been studied yet. This study aimed to evaluate the inhibitory effects on α-amylase and α-glucosidase, phytochemicals, total flavonoid content (TFC) and total phenolic content (TPC) of extracts from the aerial part of CG.