The role of OATP1A1 in cholestasis and drug-induced toxicity: a systematic review

Abstract

Organic anion transport protein 1a1 (Oatp1a1) is the prototypical member of the Oatp family of highly homologous transport proteins that are highly expressed in the liver and kidney (Cheng et al., 2005;Imai et al., 2013). In the liver, Oatp1a1 is expressed in all hepatocytes, and uniformly distributed on the basolateral (sinusoidal) surface of hepatocytes (Wang et al., 2008). Oatp1a1 expression is influenced by gender. Oatp1a1 expression in rat liver is predominantly male (Hou et al., 2014). In contrast, Oatp1a1 in kidney is predominantly female (Cheng et al., 2006). However, it is also believed that the expression of Oatp1a1 is higher in kidney of males than that of females (Cheng et al., 2005). The expression of Oatp1a1 tends to be up-regulated and then down-regulated with increasing age. Oatp1a1 is barely detectable in the liver of fetal rats, and its expression is low at birth, and increase rapidly after weaning, reaching a peak at 60 days. It then remains stable from 60 to 180 days of age, and

Quality Evaluation of Asparagus officinalis by Profile of Amino Acids and Mineral Elements in Different Parts Combined with Chemometrics Methods

“…Therefore, it was necessary to simplify the analysis process of nutritional composition further by using other chemometric methods to improve the accuracy of the quality evaluation of A. officinalis's different parts. [37] Hierarchical Cluster Analysis HCA can cluster samples according to the similarity between data to explain the relationship between data sets. To further determine the effects of 18 kinds of AA and 15 minerals on the quality of four different parts of A. officinalis, a 33×4 data matrix was drawn in this study.…”

The role of organic anion transport protein 1a4 in drug delivery and diseases: a review

“…Currently, foods have gained more attention in terms of their health support and disease-controlling ability (Kesika et al, 2022). Moreover, the study of organic anion transporters is becoming more and more important (Ji et al, 2022;Tan et al, 2022;Tao et al, 2023). Membrane transporters play an important role in the absorption, distribution and elimination of endogenous and xenobiotics, such as bile acids and drugs.…”