Synergistic antiaging effects of jujube polysaccharide and flavonoid in D-Galactose-Induced aging mice

Abstract

In this study, the synergistic effects of jujube polysaccharide (JP) and flavonoid (JF) on aging mice were investigated. Sub-acutely aging mouse models were established using D-galactose. Eighty experimental mice were randomly assigned to normal, model, vitamin C (200 mg/kg), JP (200 mg/kg), JF (200 mg/kg) and JP + JF (low (100 mg/kg), medium (200 mg/kg), and high-dose (300 mg/kg)) groups (10 mice in per group). After 35 days, the physiological aging indices of mice were measured. JP and JF displayed significantly positive synergistic antiaging effects. Compared with an aging model control group, groups administered JP and JF showed increased indices for the thymus and spleen and significantly increased activities of SOD and GSH-PX in the heart, liver, spleen, and brain (R 2 > 0.99, P < 0.01; R 2 > 0.98, P < 0.01). The contents of MDA in heart, liver, spleen, brain and serum were significantly decreased (R 2 > 0.95, P < 0.01), while those of HYP in skin and serum were significantly increased. The concentrations of neurotransmitters (NE, DA, 5-HT, 5-HIAA) in the brain and serum of mice were significantly increased (P < 0.01). These results indicated that JP and JF acted not only on relevant tissues or organs of mice, but on all body systems.

Comparison of antioxidant activities expressed as equivalents of standard antioxidant

“…Antioxidant activity refers to scavenging harmful reactive oxygen species (ROS) generated by natural physiological action or aging, excessive exercise, infection, and toxic substances in the body (Wang et al, 2022;Nunes-Silva & Freitas-Lima, 2015;Marschall & Tudzynski, 2016). In vivo ROS includes lipid radicals (R • ), alkoxyl (RO • ), peroxyl (ROO • ), and hydroxyl (OH) (Shahidi & Zhong, 2015).…”

Evaluation of maturity and moisture content in fresh jujube using fractal theory and tissue images

“…Jujube is rich in vitamins, polysaccharides, organic acids and amino acids, etc. It has high nutritional value and medicinal value, and is one of the most popular fruits for consumers (Wang et al, 2022). The maturity and moisture content directly affect the taste and fruit quality of jujube (Fu et al, 2021;Sun et al, 2022;Wang et al, 2020), therefore, the researches on jujube maturity and moisture content detection have important significance.…”