Progranulin (PGRN) is serves as an inflammation-response biomarker and promotes lung damage in burn-induced Sepsis via the SIRT1 Pathways by ROS

Ding, Hui; Shi, Zhaoling; Zhang, Lu; Gao, Nai-Rong; Cheng, Xiangdong; Lin, Haibo; Zhang, Guocheng

doi:10.1590/fst.36720

Cited by 2 publications

(2 citation statements)

References 19 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this investigation, we discovered that clove may activate SIRT1, indicating that clove may help septic mice with their cognitive impairment by up-regulating SIRT1 expression. The deacetylation of downstream signaling proteins such FOXO1, p53, and NF-κB by SIRT1 is strongly associated to the antiapoptotic, antioxidant, and anti-inflammatory effects of SIRT1 activation (Ding et al, 2022). Animals' production of interleukin 6.…”

Section: Discussionmentioning

confidence: 99%

Activation of SIRT1 signaling pathway by clove improves cognitive dysfunction in septic mice

et al. 2022

View full text Add to dashboard Cite

Clove is a kind of food spice, which can be used as food flavoring additive. In this work, we looked at clove's impact and underlying mechanism on cognitive impairment in infected mice. By using the open field test, Morris water maze, ELISA technique, kit method, and qPCR method, the biochemical and molecular biological indices of mice were identified. Clove component composition was established using HPLC. The findings demonstrated that clove might enhance mouse survival rates in comparison to the model group and could also lengthen driving distances, standing and combing periods, target quadrant duration, and crossing periods. In the hippocampus of infected mice, clove can lower levels of TNF-α, IL-6, IL-1β, and MDA while increasing SOD and CAT activity. In the hippocampus of infected animals, clove additionally increased the mRNA expression of SIRT1 and FOXO1 and decreased the mRNA expression of NF-B and p53. Animal studies revealed that clove's impact was comparable to dexamethasone in that it might help septic mice with cognitive impairment. The analysis revealed that rutin, isoquercitrin, ferulic acid, dihydroquercetin, and quercitrin were all present in clove. It is clear that clove can help septic mice with cognitive impairment by triggering SIRT1 through its active components.

show abstract

Section: Discussionmentioning

confidence: 99%

Activation of SIRT1 signaling pathway by clove improves cognitive dysfunction in septic mice

et al. 2022

View full text Add to dashboard Cite

show abstract

“…There are seven homologous genes of Sir2 in humans: namely SIRT1-7 (Wang et al, 2018). Among them, SIRT1 has the highest degree of homology and has become a research hotspot in recent years (Lu et al, 2019;Ding et al, 2021;Wang et al, 2021). SIRT1 protein has been found to exert anti-inflammatory and anti-oxidative stress effects, which can attenuate cell damage.…”

Section: Introductionmentioning

confidence: 99%

Clinic serum levels of Plin5 is therapeutic target of spinal cord injury and Plin5 reduced inflammation in spinal cord injury via silent information regulator 1 dependent inhibition of NLRP3 inflammasome

Liang

Zhao

et al. 2022

Food Sci. Technol

View full text Add to dashboard Cite

The study investigated that clinic significance and molecular mechanism of Plin5 in spinal cord injury (SCI). Serum levels of Plin5 was down-regulated and there is a negative correlation between Plin5 and IL-1β levels in patients with SCI,. Human Plin5 protein could reduce inflammation, and prevented spinal cord injury in rat model of SCI. Over-expression of Plin5 reduced inflammation divisors via activation of SIRT1 and suppression of NLRP3 in vitro model of SCI; down-regulation of Plin5 promoted inflammation divisors via inactivation of SIRT1 and induction of NLRP3 in vitro model of SCI. SIRT1 is important targets of Plin5 in inflammation divisors of SCI. The inhibition of SIRT1 reduced the effects of Plin5 on inflammation divisors of SCI. The activation of NLRP3 also reduced the effects of Plin5 on inflammation divisors of SCI. We concluded that clinic Serum levels of Plin5 is therapeutic target of SCI and Plin5 reduced inflammation in SCI via SIRT1 dependent suppression of NLRP3 Inflammasome.

show abstract

Progranulin (PGRN) is serves as an inflammation-response biomarker and promotes lung damage in burn-induced Sepsis via the SIRT1 Pathways by ROS

Cited by 2 publications

References 19 publications

Activation of SIRT1 signaling pathway by clove improves cognitive dysfunction in septic mice

Activation of SIRT1 signaling pathway by clove improves cognitive dysfunction in septic mice

Clinic serum levels of Plin5 is therapeutic target of spinal cord injury and Plin5 reduced inflammation in spinal cord injury via silent information regulator 1 dependent inhibition of NLRP3 inflammasome

Contact Info

Product

Resources

About