Anti-obesity and hepatoprotective effects in obese rats fed diets supplemented with fruit purees

Morales-Ávila, Úrsula Mireya; Becerra-Verdín, Eduardo Mendeleev; Sáyago‐Ayerdi, Sonia G.; Tolman, John P.; Montalvo‐González, Efigenia

doi:10.1590/fst.31618

Cited by 5 publications

(4 citation statements)

References 21 publications

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“…Fruit puree have a large content of vitamin D. It is found that obese rats who eat a low-fat diet supplemented with fruit puree can reduce the weight of obese rats, control blood lipid metabolism, reduce the levels of total cholesterol and triacylglycerol, reduce the expression of inflammatory markers, reduce liver injury and improve the morphology of liver, eating fruit puree may help to control and improve obesity complications caused by lipoprotein changes (Morales-Avila et al, 2020). Vegetables and fruits are also important sources of vitamin D and contain anthocyanins.…”

Section: Vitamin D and Foodmentioning

confidence: 99%

Possible action mechanisms of vitamin D supplementation in combating obesity and obesity-related issues of bone health: a mini review

et al. 2022

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Vitamin D is necessary for maintaining the bone function, and its deficiency is linked with the development of obesity. Moreover, bone health is correlated with obesity through many mechanisms by modulating bone marrow mesenchymal stem cells to differentiate as adipose cells, inflammatory response, glucose metabolism, oxidative homeostasis, energy metabolism and gut microbiota. Based on previous studies, vitamin D, obesity, and bone health are linked with each other at multiple levels. However, our knowledge of the associations of vitamin D with coexisting abnormalities, such as bone health-related issues and obesity, is still in its infancy. The complex relationships still need to be investigated and elucidated further. Therefore, in this review, the relationships between vitamin D, obesity and bone health have been discussed. This review identified that evidence proving the capacity to reduce or prevent obesity-related disorders by targeting vitamin D intakes is mainly unknown. However, the inverse relationships of vitamin D levels with obesity and bone health-related issues are apparent.

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Section: Vitamin D and Foodmentioning

confidence: 99%

Possible action mechanisms of vitamin D supplementation in combating obesity and obesity-related issues of bone health: a mini review

et al. 2022

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“…The strawberry (Fragaria ananassa) is a fruit comprised of components with important physiological activity: vitamin C, tannins, flavonoids, anthocyanins, catechin, quercetin and kaempferol, organic acids (i.e., citric, malic, oxalic, salicylic, and ellagic), and minerals (i.e., K, P, Ca, Na, and Fe) (Kallio et al, 2000;Mosquera, 2010;Ribeiro et al, 2018). As such, it is considered a functional food with multiple health benefits demonstrated by its antioxidant, anti-inflammatory, anti-hypertensive, and anti-proliferative properties (Gasperotti et al, 2015;Bastos et al, 2019) and hepatoprotector activity (Morales-Ávila et al, 2020). Additionally, the strawberry is characterized by its bright red color, a unique flavor defined by the balance of sugar and acidity, and a white or red pulp according to the variety (Perin et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Influence of gum arabic and homogenization process on the physicochemical stability of strawberry suspensions

et al. 2022

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The generation of value from the strawberry agro-chain requires in some cases the disintegration of the structure and formulation of the fruit, resulting in suspensions that behave as thermodynamically unstable colloidal systems and are affected by various forces, such as Van der Waals, electrostatic, steric, hydration, hydrophobic, and phase separation. The aim of this research was to evaluate the influence of the homogenization process and the concentration of gum arabic (GA) on the stability of strawberrybased suspensions. Strawberries with a 9% solid content were used and a centralized-composite central design was proposed (pressure (P) from 4.14-10.34 MPa), time (t) (3-5 min), and GA (0.2-0.4%)) and the dependent variables zeta potential (ζ), spectral absorption index (R), viscosity (μ), and particle size were evaluated. The ζ potential and R-index were not affected by the homogenization process and GA; the suspension was stabilized by the increase of ζ due to t, the GA effect, and the t-GA interaction. Particle size was affected by P but not by t, whereas GA mainly affected D [3,2], D [4,3], and D90. The results indicate that the homogenization and the use of GA as a hydrocolloid confer chemo-physical stability to the strawberry suspension.

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“…Compared with traditional chemotherapy drugs, TCMs are less toxic, causing fewer side effects, and are relatively inexpensive. (Mostafa et al, 2021;Wang & Jin, 2021;Morales-Ávila et al, 2020) TCMs have been combined with various conventional clinical therapies to treat HCC and may enhance tumor sensitivity to radiotherapy and chemotherapy, reduce toxicity and side effects, and improve the quality of life and survival rate of patients (Ling et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

PP-10 induces apoptosis via JNK/SPAK activation and STAT3 inhibition in Hepatocarcinoma cells in vitro

Wang

et al. 2022

Food Sci. Technol

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Background: The detail of mechanism involving in PP-10 anti-cancer activity remains to be elucidated, and the effect on HCC cells is unknown. Methods: MTT and colony formation assays were used to determine the effect of PP-10 on cell growth. Flow cytometry analysis and Hoechst 33258 were used to assess apoptosis. Gene set enrichment analysis (GSEA) was used to explore changes in apoptosis-associated pathways. Western blotting was used to detect protein expression levels. Results: In our study, PP-10 significantly suppressed cancer cell viability while had low toxicity to normal cells, with the HCC cell lines HepG2 and HuH7 being particularly sensitive to PP-10 treatment. PP-10 induced mitochondrial-related apoptosis in HepG2 and HuH7 cells. Moreover, GSEA showed that the MAPK signaling pathway could be correlated with PP-10-induced apoptosis. We used western blotting to confirm that PP-10 induced apoptosis in HepG2 and HuH7 cells by modulating the JNK/SPAK signaling and inhibiting the STAT3 signaling pathway. Conclusion: Collectively, our results show that PP-10 induces apoptosis via the JNK/SPAK and STAT3 signaling pathways in HepG2 and HuH7 hepatocarcinoma cells.

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Anti-obesity and hepatoprotective effects in obese rats fed diets supplemented with fruit purees

Cited by 5 publications

References 21 publications

Possible action mechanisms of vitamin D supplementation in combating obesity and obesity-related issues of bone health: a mini review

Possible action mechanisms of vitamin D supplementation in combating obesity and obesity-related issues of bone health: a mini review

Influence of gum arabic and homogenization process on the physicochemical stability of strawberry suspensions

PP-10 induces apoptosis via JNK/SPAK activation and STAT3 inhibition in Hepatocarcinoma cells in vitro

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