Extraction of lycopene from tomato pomace and its protective effects on renal injury in diabetic rats

Abstract

The aim of this study was to investigate the protective effects of lycopene from tomato pomace on renal injury in diabetic rats. Lycopene was extracted from tomato pomace. The rats were divided into control, model and 10, 20 and mg/kg lycopene groups. The diabetic nephropathy model was constructed in the latter four groups. Then, the latter three groups were treated with 10, 20 and mg/kg lycopene, respectively. After four weeks of treatment, compared with the model group, in 20 and 40 mg/kg lycopene groups the serum fasting plasma glucose level was decreased (P < 0.05), the fasting insulin level was increased (P < 0.05), the renal index and 24-h urinary protein level were decreased (P < 0.05), the blood urea nitrogen and serum creatinine levels were decreased (P < 0.05), the renal tissue superoxide dismutase and glutathione peroxidase levels were increased (P < 0.05), the renal tissue malondialdehyde level was decreased (P < 0.05), and the serum tumor necrosis factor α, interleukin 6 and hypersensitive C-reactive protein levels were decreased (P < 0.05). In conclusion, lycopene from tomato pomace can alleviate renal injury in diabetic rats. The mechanism may be related to the resistance of oxidative stress and inflammatory response.

Recent advances in the fabrication, characterization and application of starch-based materials for active food packaging: hydrogels and aerogels

“…Besides, edible coatings are transparent films that can also be used in fruit packaging as an alternative to the wax that naturally occurs on the surface of the fruit. 90…”

Potential health effects of tomato (lycopersicon esculentum) juice and hypoglycemic amelioration in the atherogenic indices between diabetic animal models

“…Indeed, there was an association between free radical-induced lipid peroxidation and decreased antioxidant enzymes activity, linked to elevated oxidative stress in DM, a key factor for diabetic complications. Also, alteration in the endogenous free radicals quenching defense mechanisms may cause insufficient scavenging, leading to oxidative damage and tissue injury (Xie et al, 2022). Additionally, Eliza et al (2009) showed that STZ elevate the lipid peroxides level and reduce the antioxidant enzymes activity of diabetic rats.…”

“…On the other hand, having healthy diets as shown with many previous evidences; eating fruits and vegetables lowers the risk of oxidative damage due to their great levels of the natural antioxidants (Ojetola et al, 2021). So it is quite important to consume healthy diets and/ or consume dietary food supplements containing antioxidant molecules in order to regulate oxidative stress (Xie et al, 2022) and help to maintain cell and tissue homeostasis in addition to prevent inflammation and chronic metabolic diseases (Dini, 2021). Again, the potential main role for the antioxidants within the human body is the defense from free radicals; stopping and/ or decreasing free radicals development by different enzyme activities (Xie et al, 2022) such as glutathione peroxidase (GSH.…”

“…So it is quite important to consume healthy diets and/ or consume dietary food supplements containing antioxidant molecules in order to regulate oxidative stress (Xie et al, 2022) and help to maintain cell and tissue homeostasis in addition to prevent inflammation and chronic metabolic diseases (Dini, 2021). Again, the potential main role for the antioxidants within the human body is the defense from free radicals; stopping and/ or decreasing free radicals development by different enzyme activities (Xie et al, 2022) such as glutathione peroxidase (GSH. Px), reduced glutathione (GSH.Rd) and Superoxide dismutase (SOD) in co-operation with metal cofactors such as Manganese (Mn), Copper (Cu), Selenium (Se) and Zinc (Zn) (Dini & Laneri, 2019).…”

“…Indeed, fresh or cooked tomatoes consumption have been reported by their high nutritive value especially their beneficial to DM complications (Rodrigues et al, 2022) and that due to a reduction in the oxidative stress biomarkers, inflammation, accelerated atherosclerosis, and tissue damage (Banihani, 2018). Also, diabetes as high glucose levels cause kidney damage and impairment in renal function, resulting in rise in the concentrations of urea, creatinine and uric acid which is considered indicators of renal dysfunction (Xie et al, 2022). Furthermore, tomatoes showed high lipid metabolism levels that have been induced by genes over expression; the one that has been involved in more efficient fatty acid oxidation (Mohammed et al, 2020).…”