Correlation between antioxidant activity and anti-wrinkle effect of ethanol extracts of Sanguisorba Officinalis L.

Byun, Na-Young; Cho, Joong-Hyun; Yim, Soon‐Ho

doi:10.1590/fst.10921

Cited by 8 publications

(8 citation statements)

References 23 publications

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“…Mentha piperita was reported to contain menthoside as one of the flavonoids reported for its antioxidant, and anti-inflammatory properties ( Biswas et al, 2014 ). Ziguglycoside II from the root part of Sanguisorba officinalis was reported to have antioxidant properties ( Byun et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Mollugo oppositifolia Linn. as cholinesterase and β-secretase enzymes inhibitor

Das

Bhardwaj²,

Sharma³

et al. 2023

Front. Pharmacol.

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Mollugo oppositifolia Linn. is traditionally used in neurological complications. The study aimed to investigate in-vitro neuroprotective effect of the plant extracts through testing against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-secretase linked to Alzheimer’s disease (AD). To understand the safety aspects, the extracts were tested for CYP450 isozymes and human hepatocellular carcinoma cell (HepG2) inhibitory potential. The heavy metal contents were estimated using atomic absorption spectroscopy (AAS). Further, the antioxidant capacities as well as total phenolic content and total flavonoid content (TFC) were measured spectrophotometrically. UPLC-QTOF-MS/MS analysis was employed to identify phytometabolites present in the extract. The interactions of the ligands with the target proteins (AChE, BChE, and BACE-1) were studied using AutoDockTools 1.5.6. The results showed that M. oppositifolia extract has more selectivity towards BChE (IC50 = 278.23 ± 1.89 μg/ml) as compared to AChE (IC50 = 322.87 ± 2.05 μg/ml). The IC50 value against β-secretase was 173.93 μg/ml. The extract showed a CC50 value of 965.45 ± 3.07 μg/ml against HepG2 cells and the AAS analysis showed traces of lead 0.02 ± 0.001 which was found to be within the WHO prescribed limits. Moreover, the IC50 values against CYP3A4 (477.03 ± 2.01 μg/ml) and CYP2D6 (249.65 ± 2.46 μg/ml) isozymes justify the safety aspects of the extract. The in silico molecular docking analysis of the target enzymes showed that the compound menthoside was found to be the most stable and showed a good docking score among all the identified metabolites. Keeping in mind the multi-targeted drug approach, the present findings suggested that M. oppositifolia extract have anti-Alzheimer’s potential.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Mollugo oppositifolia Linn. as cholinesterase and β-secretase enzymes inhibitor

Das

Bhardwaj²,

Sharma³

et al. 2023

Front. Pharmacol.

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“…The antioxidant properties of SO are derived from its phenolic acid and flavonoid compounds [ 32 ]. In addition to quercitrin, which was used as an index ingredient in this study, the main components in the leaves and stems of SO contained ellagic acid, caffeoylquinic acid, rosmarinic acid, ursolic acid, sanguisorbic acid, catechin, quercetin, kaempferol, sanguisorbigenin, and sanguiin [ 17 , 33 ]. These compounds exhibited antioxidant activity, among which ellagic acid [ 34 ], caffeoylquinic acid [ 35 ], rosmarinic acid [ 36 ], ursolic acid [ 37 ], catechin [ 38 ], and quercetin [ 39 ] have been reported to enhance SOD activity in obese mice.…”

Section: Discussionmentioning

confidence: 99%

“…Sanguisorba officinalis L. (SO) is widely distributed as a medicinal natural product in China, Korea, and Japan and is well known for its antioxidant properties [ 17 , 18 ]. SO has been proven to have anti-inflammatory [ 19 ], antibacterial [ 20 ], antitumor [ 21 ], and hypoglycemic [ 22 ] physiological activities in addition to its antioxidant effects.…”

Section: Introductionmentioning

confidence: 99%

Standardized Sanguisorba officinalis L. Extract Inhibits Adipogenesis and Promotes Thermogenesis via Reducing Oxidative Stress

Zheng

Lee

et al. 2023

Antioxidants

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Obesity produces many health problems, including systemic oxidative stress. This study comprehensively investigated the effects of Sanguisorba officinalis L. extract (SO) as an antioxidant on abnormal lipid accumulation and oxidative stress in 3T3-L1 adipocytes and high-fat diet (HFD)-induced obese mice (n = 48). We evaluated the anti-adipogenic and antioxidant effects of SO on 3T3-L1 by cell viability, Oil red O staining, and NBT assays. The ameliorative effects of SO in HFD-induced C57BL/6J mice were investigated by measuring body weight, serum lipids, adipocyte size, hepatic steatosis, AMPK pathway-related proteins, and thermogenic factors. In addition, the effect of SO on oxidative stress in obese mice was evaluated by the activity of antioxidant enzymes and the production of lipid peroxidation products and ROS production in adipose tissue. We found that SO dose-dependently decreased lipid accumulation and ROS production in 3T3-L1 adipocytes. In C57BL/6J obese mice, SO (above 200 mg/kg) attenuated the HFD-induced gain in body weight and white adipose tissue (WAT) weight without affecting appetite. SO also decreased serum glucose, lipid, and leptin levels and attenuated adipocyte hypertrophy and hepatic steatosis. Furthermore, SO increased the expression of SOD1 and SOD2 in WAT, decreased ROS and lipid peroxides, and activated the AMPK pathway and thermogenic factors. In summary, SO reduces oxidative stress in adipose tissue by increasing antioxidant enzyme activity and improves obesity symptoms through AMPK-pathway-regulated energy metabolism and mitochondrial respiratory thermogenesis.

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“…The ABTS radical scavenging activity of the TPS-Fe(III) complex was determined using the method described (Wang et al, 2021;Byun et al, 2021;Hu et al, 2021), with minor modifications. ABTS (0.3841 g) and potassium persulfate (0.0662 g) were accurately weighed and then dissolved in 20 mL deionised water.…”

Section: ( ) (mentioning

confidence: 99%

Characterisation and antioxidant activity of polysaccharide iron (III) complex in Qingzhuan Dark Tea

ZHOU

WANG

et al. 2022

Food Sci. Technol

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Correlation between antioxidant activity and anti-wrinkle effect of ethanol extracts of Sanguisorba Officinalis L.

Cited by 8 publications

References 23 publications

Evaluation of Mollugo oppositifolia Linn. as cholinesterase and β-secretase enzymes inhibitor

Evaluation of Mollugo oppositifolia Linn. as cholinesterase and β-secretase enzymes inhibitor

Standardized Sanguisorba officinalis L. Extract Inhibits Adipogenesis and Promotes Thermogenesis via Reducing Oxidative Stress

Characterisation and antioxidant activity of polysaccharide iron (III) complex in Qingzhuan Dark Tea

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