Sanguisorba officinalis L., the dried roots of which are referred to as cucumber herb is a perennial herb belonging to the family Rosaceae. This study was showed the correlation between the antioxidant activity and its anti-wrinkle effects of ethanol extraction concentration of S. officinalis L. The extraction yield of the S. officinalis extracts was all 10% or more, which was judged to be economical. 80% ethanol extracts was the highest in total polyphenol and flavonoid contents and the best total antioxidant activity. The correlation between total polyphenol and flavonoid contents and antioxidant activity was 0.830 and 0.872, respectively, with a significant correlation was confirmed. In addition, in 80% ethanol extracts, superoxide anion and NO radical scavenging activities were the most effective. These results validated that the optimum extraction concentration for S. officinalis was 80% ethanol.
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