Corosolic acid improves erectile function in metabolic syndrome rats by reducing reactive oxygen species generation and increasing nitric oxide bioavailability

LI, Bi-Bo; Pang, Kun; Lin, Hao; Zang, Guanghui; Wang, Jian; WANG, Xi-Tao; Zhang, Jianjun; Cai, Longjun; YANG, Chen-Di; HAN, Cong-Hui

doi:10.1590/fst.108821

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…ROS play an important role in the body. A lower level of ROS promotes the cellular proliferation, differentiation, tissue regeneration and metabolism, and the high concentrations of ROS induce cell apoptosis and necrosis by oxidative stress (Li et al, 2022). Results of this study showed that, with the increase of TT-ACFM concentration, the fluorescence intensity of ROS gradually increased.…”

Section: Discussionmentioning

confidence: 62%

Preparation of total triterpenoids from Antrodia cinnamomea fermentation mycelium and their in vitro inhibitory effects on hepatocellular carcinoma

Zhi

Tang

2023

Food Sci. Technol

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Total triterpenoids from Antrodia cinnamomea fermentation mycelium (TT-ACFM) were prepared, and their in vitro inhibitory effects on hepatocellular carcinoma were investigated. Human hepatocellular carcinoma HepG2 cells were incubated with TT-ACFM with concentration of 0 (control), 12.5, 25, 50, 100 and 200 μg/mL, respectively. The proliferation of cell was detected using CCK-8 method. The apoptosis of cells was detected by flow cytometry. The migration and invasion of cells was determined using Transwell chamber. The level of reactive oxygen species (ROS) in cells was determined using DCFH-DA method. The expressions of matrix metalloproteinse-2 (MMP-2), matrix metalloproteinse-9 (MMP-9) and vascular endothelial growth factor (VEGF) protein in cells were detected by western blot assays. Results indicate that, TT-ACFM can not only inhibit the proliferation of HepG2 cells and promote their apoptosis, but also inhibit their invasion and invasion. The mechanism may be related to its increase of ROS and down-regulation of MMP-2, MMP-9 and VEGF expression in cells.

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Section: Discussionmentioning

confidence: 62%

Preparation of total triterpenoids from Antrodia cinnamomea fermentation mycelium and their in vitro inhibitory effects on hepatocellular carcinoma

Zhi

Tang

2023

Food Sci. Technol

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“…As a marker, MDA is often used to detect the oxidative stress (Reiter et al, 2014;Ho et al, 2013). There are some antioxidant mechanisms against ROS production and oxidative damage in cells (Li et al, 2022). Cellular antioxidant enzyme, including SOD and CAT, can effectively remove hydrogen peroxide and lipid peroxide, and efficiently detoxify superoxide anion (Mruk et al, 2002).…”

Section: Determination Of Sod Cat Mda Total Protein and Albumin In Serummentioning

confidence: 99%

Improvement effect of enzymic polypeptide from Paeonia ostii seed meal on protein-energy malnutrition mouse model

Liang

Yang

et al. 2023

Food Sci. Technol

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The improvement effects of enzymatic polypeptide of Paeonia ostii seed meal (APHP) on model mice of protein-energy malnutrition were evaluated by body weight changes, organ indices, levels of SOD, CAT, MDA, total protein and albumin in serum, staining images of major organs and macrophages phagocytosis. The results indicated the mice body weight recovery was dose-dependent with APHP and the body weight change of model mice fed with high-dose APHP (5.0 g/kg) and normal diet showed a same recovery effect. The model mice had higher thymus and spleen indexes than other groups. And the values of SOD, CAT, MDA, total protein and albumin in serum returned to normal level after 30, 60, 45, 30 and 45 days respectively, which was better than those of normal diet. Our research will provide basic data support for new potential applications of APHP and increase the added value of Paeonia ostii processing enterprises.

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“…It is also known as “phyto-insulin” or “plant insulin” because of its excellent antidiabetic effects [ 20 ]. Various pharmacological studies have shown that corosolic acid has anti-obesity [ 21 ], anti-inflammatory [ 22 ], anti-hyperlipidaemic [ 22 ], anti-viral, and anti-cancer properties [ 23 ]. Based on these considerations, the present study aimed to determine whether corosolic acid has a cardioprotective effect in diabetic rats and to explore the mechanisms involved.…”

Section: Introductionmentioning

confidence: 99%

The Cardioprotective Effect of Corosolic Acid in the Diabetic Rats: A Possible Mechanism of the PPAR-γ Pathway

et al. 2023

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The study was conducted to determine whether corosolic acid could protect the myocardium of diabetic rats from damage caused by isoproterenol (ISO) and, if so, how peroxisome proliferator-activated receptor gamma (PPAR-γ) activation might contribute into this protection. Diabetes in the rats was induced by streptozotocin (STZ), and it was divided into four groups: the diabetic control group, diabetic rats treated with corosolic acid, diabetic rats treated with GW9662, and diabetic rats treated with corosolic acid plus GW9662. The study was carried out for 28 days. The diabetic control and ISO control groups showed a decrease in mean arterial pressure (MAP) and diastolic arterial pressure (DAP) and an increase in systolic arterial pressure (SAP). The rat myocardium was activated by corosolic acid treatment, which elevated PPAR-γ expression. A histopathological analysis showed a significant reduction in myocardial damage by reducing myonecrosis and edema. It was found that myocardial levels of CK-MB and LDH levels were significantly increased after treatment with corosolic acid. By decreasing lipid peroxidation and increasing endogenous antioxidant levels, corosolic acid therapy showed a significant improvement over the ISO diabetic group. In conclusion, our results prove that corosolic acid can ameliorate ISO-induced acute myocardial injury in rats. Based on these results, corosolic acid seems to be a viable new target for the treatment of cardiovascular diseases and other diseases of a similar nature.

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Corosolic acid improves erectile function in metabolic syndrome rats by reducing reactive oxygen species generation and increasing nitric oxide bioavailability

Cited by 3 publications

References 18 publications

Preparation of total triterpenoids from Antrodia cinnamomea fermentation mycelium and their in vitro inhibitory effects on hepatocellular carcinoma

Preparation of total triterpenoids from Antrodia cinnamomea fermentation mycelium and their in vitro inhibitory effects on hepatocellular carcinoma

Improvement effect of enzymic polypeptide from Paeonia ostii seed meal on protein-energy malnutrition mouse model

The Cardioprotective Effect of Corosolic Acid in the Diabetic Rats: A Possible Mechanism of the PPAR-γ Pathway

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