Functional food ingredients for control of gestational diabetes mellitus: a review

Lin, Huiting; Li, Shiyang; Zhang, Jiawen; Lin, Shaoling; Tan, Bee K.; Hu, Jiamiao

doi:10.1590/fst.03621

Cited by 7 publications

(10 citation statements)

References 66 publications

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“…Based on the scientific results summarized below, polyphenols could be at least part of the answer to this important challenge. Numerous studies report the antidiabetic effects of dietary polyphenols due to their anti-inflammatory and antioxidant effects, as well as their positive effects on insulin secretion and the insulin signaling pathway [13,14,107]. The results from several studies also support the notion that some dietary polyphenols can modulate cellular and whole-body energy homeostasis under stress conditions during pregnancy, influencing AMP-activated protein kinase, the crucial cellular energy sensor [107].…”

Section: Gestational Diabetes Mellitusmentioning

confidence: 85%

The Role of Dietary Polyphenols in Pregnancy and Pregnancy-Related Disorders

et al. 2022

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Polyphenols are a group of phytochemicals with extensive biological functions and health-promoting potential. These compounds are present in most foods of plant origin and their increased widespread availability through the intake of nutritional supplements, fortified foods, and beverages, has also led to increased exposure throughout gestation. In this narrative review, we focus on the role of polyphenols in both healthy and pathological pregnancy. General information related to their classification and function is followed by an overview of their known effects in early-pregnancy events, including the current insights into molecular mechanisms involved. Further, we provide an overview of their involvement in some of the most common pregnancy-associated pathological conditions, such as preeclampsia and gestational diabetes mellitus. Additionally, we also discuss the estimated possible risk of polyphenol consumption on pregnancy outcomes. The consumption of dietary polyphenols during pregnancy needs particular attention considering the possible effects of polyphenols on the mechanisms involved in maternal adaptation and fetal development. Further studies are strongly needed to unravel the in vivo effects of polyphenol metabolites during pregnancy, as well as their role on advanced maternal age, prenatal nutrition, and metabolic risk of the offspring.

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Section: Gestational Diabetes Mellitusmentioning

confidence: 85%

The Role of Dietary Polyphenols in Pregnancy and Pregnancy-Related Disorders

et al. 2022

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“…The diabetic mouse model induced by streptozotocin (STZ) is a relatively common modeling method (Lin et al, 2021). In this the accumulation of ROS in HG-treated renal tubular epithelial cells (Zeng et al, 2018).…”

Section: Parthenolide Relieves Stz-induced Diabetic Nephropathy In Micementioning

confidence: 99%

Parthenolide regulates DNMT1-mediated methylation of VDR promoter to relieve podocyte damage in mice with diabetic nephropathy

Zhang

Yang²,

Yu³

et al. 2022

Food Sci. Technol

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Current evidence showed that parthenolide (PN) has strong anti-inflammatory activity, but its effect on diabetic nephropathy (DN) is still unclear. In this research, high glucose (HG)-induced MPC5 cells were incubated with 5, 10 or 20 μM PN, and we found that PN incubation improved HG-induced MPC5 cells viability and apoptosis, ROS level, LDH activity and the secretion of inflammatory factors (IL-6, TNF-α and IL-1β), and inhibited the expression of DNMT1 protein, and promoted the expression of VDR, p-AKT, nephrin and podocin proteins. Lentivirus-mediated VDR overexpression vector (LV-VDR) transfection had the same effect, and LV-DNMT1 or si-VDR transfection or 100 nM AKT inhibitor MK2206 incubation reversed the effect of PN on cell functions. Research on the mechanism found that PN reduced the level of VDR methylation by reducing the enrichment of DNTM1 in the VDR promoter region under high glucose condition. In vivo, C57BL/6 mice were injected with streptozotocin (STZ) intraperitoneally to construct a DN mouse model, and 5mg/kg PN was administered intraperitoneally every other day. The results showed that PN treatment improved glomerular hypertrophy and renal fibrosis in STZ-induced mice. In general, PN regulated DNTM1-mediated VDR methylation, activated AKT, and alleviated DN.

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“…This present work aimed to provide the summary of in vivo research discussing the effects of nutmeg samples on glycemic status in rats and mice. The output is essential for developing functional ingredients that can be applied to food products to provide various benefits, including helping to relieve DM through various mechanisms (Lin et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Effect of nutmeg on glycemic status in rat and mice: a systematic review

et al. 2023

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Glycemic status depicts a state of individual blood glucose level. Biochemical parameters to identify glycemic status associated with diabetes mellitus include fasting or non-fasting blood glucose, HbA1c, and oral glucose tolerance. Our present work conducted a systematic review aiming to systematically summarize the in vivo experimental results of nutmeg treatments towards the glycemic status of rats and mice. The systematic review followed PRISMA guidelines. PubMed, ProQuest, Wiley Online Library, and Google Scholar were used as databases for searching articles. Twenty-one articles that met the criteria were eventually used in this systematic review. The results of the in vivo studies revealed that the intervention of nutmeg samples in rats and mice had a positive effect. This finding was present in all reviewed articles. Overall, treatment by nutmeg samples was able to attenuate fasting blood glucose, non-fasting blood glucose, and HbA1c in rats and mice, reaching up to 94.52, 60.76, and 48.86%. We also found that nutmeg samples prepared from mace and methanol had the highest effect in reducing blood glucose. Based on this systematic review, it can be concluded that nutmeg has a positive effect on improving glycemic status and reducing the risk of DM in rats and mice.

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Functional food ingredients for control of gestational diabetes mellitus: a review

Cited by 7 publications

References 66 publications

The Role of Dietary Polyphenols in Pregnancy and Pregnancy-Related Disorders

The Role of Dietary Polyphenols in Pregnancy and Pregnancy-Related Disorders

Parthenolide regulates DNMT1-mediated methylation of VDR promoter to relieve podocyte damage in mice with diabetic nephropathy

Effect of nutmeg on glycemic status in rat and mice: a systematic review

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