Tissue healing efficacy in burn patients treated with 1% silver sulfadiazine versus other treatments: a systematic review and meta-analysis of randomized controlled trials

Maciel, Alex Bezerra da Silva; Ortiz, Josmar França; Siqueira, Beatriz Santos; Zanette, Gabriela Ferreira

doi:10.1590/abd1806-4841.20198321

Cited by 10 publications

(4 citation statements)

References 14 publications

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“…The acticoat dressing can be kept for 3 days, so it was considered a good treatment option. Maciel et al (2019) reported that SP had shown excellent effectiveness as a bactericide, in addition to being well accepted by burn centres. Various products have been compared, such as aloe vera, aquacel, and centiderm, which have shown efficacy compared to SP, although it is considered too early to declare their efficacy.…”

Section: Antibacterial Ointmentsmentioning

confidence: 99%

Management of post-surgical infection of onychocryptosis with topical application of hyaluronic acid versus antibacterial ointments

Fernández

Armell

Gómez-Carrión

et al. 2022

Heliyon

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Section: Antibacterial Ointmentsmentioning

confidence: 99%

Management of post-surgical infection of onychocryptosis with topical application of hyaluronic acid versus antibacterial ointments

Fernández

Armell

Gómez-Carrión

et al. 2022

Heliyon

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Section: Silvermentioning

confidence: 99%

“…No significant difference was found in the average wound-healing time, but Flaminal ® Forte was deemed advantageous due to Antibiotics 2020, 9, 90 3 of 24 less frequently required dressing changes [33]. Finally, a 2019 meta-analysis of 81 studies found that 11/11 studies that met the inclusion criteria of the review found silver sulfadiazine to be inferior to alternative treatments in the mean wound-healing time [34].In the last 20 years, some new classes of silver complexes have garnered attention for their antibacterial properties, in particular N-heterocyclic carbene (NHC) complexes of silver(I). A comprehensive summary of antimicrobial silver compounds can be found in several recent reviews [27,[35][36][37].…”

mentioning

confidence: 99%

Metal Complexes, an Untapped Source of Antibiotic Potential?

2020

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With the widespread rise of antimicrobial resistance, most traditional sources for new drug compounds have been explored intensively for new classes of antibiotics. Meanwhile, metal complexes have long had only a niche presence in the medicinal chemistry landscape, despite some compounds, such as the anticancer drug cisplatin, having had a profound impact and still being used extensively in cancer treatments today. Indeed, metal complexes have been largely ignored for antibiotic development. This is surprising as metal compounds have access to unique modes of action and exist in a wider range of three-dimensional geometries than purely organic compounds. These properties make them interesting starting points for the development of new drugs. In this perspective article, the encouraging work that has been done on antimicrobial metal complexes, mainly over the last decade, is highlighted. Promising metal complexes, their activity profiles, and possible modes of action are discussed and issues that remain to be addressed are emphasized.Antibiotics 2020, 9, 90 2 of 24 Metal-containing compounds have played a small but seminal role in medicinal chemistry of throughout the 20th century. An arsenic-containing compound, Salvarsan, was discovered at the beginning of the century and became the first effective treatment of syphilis [9]. It was however the discovery of the anticancer drug cisplatin and its successors that really kickstarted the field of inorganic medicinal chemistry. Even today, platinum-based chemotherapeutics are still used in the majority of cancer treatments [10]. The gold-containing auranofin is an approved drug for the treatment of rheumatoid arthritis and is currently under investigation for its anticancer as well as antimicrobial properties [11][12][13][14][15][16]. Invigorated by these breakthrough successes, the field has expanded to many other elements in the last few decades, with complexes of titanium, iron, ruthenium, gallium, palladium, silver, gold, bismuth, and copper entering clinical trials [17][18][19][20][21][22]. The medicinal applications of these metal complexes range from anticancer to antimalaria over to neurodegenerative diseases. Strangely, antibacterial applications are remarkably sparse in this list and the number of literature reports on metal-based antimicrobials is dwarfed by the much more frequent publications on metal-based anticancer compounds. This is surprising as metals such as bismuth and silver have long been known to possess antibacterial properties. Some medicinal products are currently available. There are however a variety of products, such as silver-coated underwear, with a more dubious scientific basis. Nevertheless, the systematic evaluation of the antimicrobial properties of metal complexes has increased in pace over the last decade, with several reports highlighting the activity and potential modes of action of metal-based antibiotics. This perspective article will discuss the major discoveries in the non-traditional field of metal complex-based antibiotic co...

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“…For burn wounds, other alternative therapies are superior in another meta-analysis. 21 Silver sulfadiazine was also demonstrated to impair re-epithelialization more compared to nanosilver in a study comparing conjugated silver dressings. 22 The results show, albeit from a small sample size, a trend for advanced wound dressings to have betterwound outcomes compared to basic wound dressings.…”

Section: Head N=6mentioning

confidence: 99%

The Clinical Profile, Wound Dressings, and Clinical Outcomes of In-patients with Pressure Ulcers at a Tertiary Hospital in the Philippines: A Seven-year Retrospective Study

Barit¹,

Abalos-Babaran²,

Obbus³

et al. 2021

Acta Med Philipp

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Objectives. Currently, there are no local studies examining wound dressing usage among pressure ulcers in Filipino patients. The study aims to provide preliminary Philippine data among in-patients with pressure ulcers: their demographic characteristics, wound characteristics, wound dressing usage, and associated outcomes per wound dressing. Methods. A retrospective chart review of patients admitted at the Philippine General Hospital from 2011 to 2017 with a diagnosis of pressure ulcer was conducted. Results. Eighty-five records were retrieved; 56% were female and 44% male, with a mean age of 47.67 ± 23.03 years. The mean number of ulcers per patient was 1.65 ± 1.37, mostly in Stages 2 and 3, and 90.6% were in the sacral area. Seventy-three (85.9%) had utilized at least one form of the wound dressing, mostly plain gauze (83.5%), usually with silver sulfadiazine or Dakin’s solution. Only a smaller subset used silver-impregnated dressings (10.55%) and hydrocolloid dressings (5.9%). Comparing advanced versus basic dressings for improved wound outcomes, the crude odds ratio was 3.81 (1.62 - 8.99; p-value 0.003), which on stratification accounting for bed turning, became 8.92 (1.66 - 47.97; p-value 0.009) for those bed turned and 3.05 (1.01-9.20; p-value 0.075) for those not bed turned. Conclusion. Filipino in-patients with pressure ulcers were similar to those in the literature in terms of the mean number of ulcers and site of involvement. Basic gauze dressings, combined with topical agents, constitute the majority of wound dressing practice. Use of an advanced wound dressing showed a trend favoring improved outcomes, enhanced by pressure redistribution through bed repositioning.

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Tissue healing efficacy in burn patients treated with 1% silver sulfadiazine versus other treatments: a systematic review and meta-analysis of randomized controlled trials

Cited by 10 publications

References 14 publications

Management of post-surgical infection of onychocryptosis with topical application of hyaluronic acid versus antibacterial ointments

Management of post-surgical infection of onychocryptosis with topical application of hyaluronic acid versus antibacterial ointments

Metal Complexes, an Untapped Source of Antibiotic Potential?

The Clinical Profile, Wound Dressings, and Clinical Outcomes of In-patients with Pressure Ulcers at a Tertiary Hospital in the Philippines: A Seven-year Retrospective Study

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