This study aims to evaluate tissue healing efficacy in burn patients treated with
1% silver sulfadiazine
versus
other treatments.
This is a systematic literature review and meta-analysis of randomized clinical
trials performed according to the Preferred Reporting Items for Systematic
Reviews and Meta-Analyzes (PRISMA) and PICO strategy, registered in the
International Prospective Register of Systematic Reviews (PROSPERO) under the
number CRD42017081057.
The review found 71 studies in MEDLINE/Pubmed, 1 in Clinical Trials, 19 in the
Cochrane Library, and 4 in LILACS in five manual searches. Of these, 81 studies
were pre-selected. After independent analysis by two reviewers, only 11 studies
met the inclusion criteria for the review.
All studies (n = 11) using alternative treatments to silver sulfadiazine were
shown to be superior in the mean time for complete wound healing, with
statistically significant differences between experimental and control groups (p
<0.00001); mean difference (- 4.26), 95% CI [- 5.96, - 2.56].
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